CD163<sup>+</sup> Foamy Macrophages Are Associated with the Morphogenesis of Oral Verruciform Xanthoma through Angiogenesis by VEGF Expression: An Immunohistochemical Study
Oral verruciform xanthoma (OVX) is an uncommon benign lesion that is characterized histologically by the accumulation of several foamy macrophages in the lamina propria papillae. The pathogenesis of OVX has not been completely elucidated, although the significance of macrophage polarization (M1, tum...
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| Format: | Article |
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MDPI AG
2020-02-01
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| Series: | Dentistry Journal |
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| Online Access: | https://www.mdpi.com/2304-6767/8/1/18 |
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| author | Manabu Shigeoka Yu-ichiro Koma Takayuki Kodama Mari Nishio Masaya Akashi Hiroshi Yokozaki |
| author_facet | Manabu Shigeoka Yu-ichiro Koma Takayuki Kodama Mari Nishio Masaya Akashi Hiroshi Yokozaki |
| author_sort | Manabu Shigeoka |
| collection | DOAJ |
| description | Oral verruciform xanthoma (OVX) is an uncommon benign lesion that is characterized histologically by the accumulation of several foamy macrophages in the lamina propria papillae. The pathogenesis of OVX has not been completely elucidated, although the significance of macrophage polarization (M1, tumor suppression; and M2, tumor promotion) and the contribution of M2 macrophages to angiogenesis are well established. This study investigated the role of foamy macrophages in OVX, with a focus on angiogenesis. Four patients who underwent surgical excision or total excisional biopsy for OVXs were enrolled in this study. We evaluated the expression of the macrophage markers CD68 (broad) and CD163 (M2) and the CD34-positive microvessel density (MVD) of OVXs. The foamy macrophages of all patients exhibited positivity to CD68 and CD163. We evaluated the MVD and the expression of the vascular endothelial growth factor (VEGF) based on histological architecture. The MVD of all OVX cases was significantly higher than that of the corresponding normal epithelia. Interestingly, the MVD of verrucous-type OVX cases was higher than that of the other type. VEGF was expressed on foamy macrophages in all cases. Overall, the foamy macrophages expressing CD163 were associated with the morphogenesis of OVX through the process of angiogenesis by VEGF expression. |
| first_indexed | 2024-04-14T01:40:49Z |
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| id | doaj.art-ee8a59e5ff574cf2b8489f2ce69d6df3 |
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| issn | 2304-6767 |
| language | English |
| last_indexed | 2024-04-14T01:40:49Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Dentistry Journal |
| spelling | doaj.art-ee8a59e5ff574cf2b8489f2ce69d6df32022-12-22T02:19:46ZengMDPI AGDentistry Journal2304-67672020-02-01811810.3390/dj8010018dj8010018CD163<sup>+</sup> Foamy Macrophages Are Associated with the Morphogenesis of Oral Verruciform Xanthoma through Angiogenesis by VEGF Expression: An Immunohistochemical StudyManabu Shigeoka0Yu-ichiro Koma1Takayuki Kodama2Mari Nishio3Masaya Akashi4Hiroshi Yokozaki5Division of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, JapanDivision of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, JapanDivision of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, JapanDivision of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, JapanDivision of Oral and Maxillofacial Surgery, Department of Surgery Related, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, JapanDivision of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, JapanOral verruciform xanthoma (OVX) is an uncommon benign lesion that is characterized histologically by the accumulation of several foamy macrophages in the lamina propria papillae. The pathogenesis of OVX has not been completely elucidated, although the significance of macrophage polarization (M1, tumor suppression; and M2, tumor promotion) and the contribution of M2 macrophages to angiogenesis are well established. This study investigated the role of foamy macrophages in OVX, with a focus on angiogenesis. Four patients who underwent surgical excision or total excisional biopsy for OVXs were enrolled in this study. We evaluated the expression of the macrophage markers CD68 (broad) and CD163 (M2) and the CD34-positive microvessel density (MVD) of OVXs. The foamy macrophages of all patients exhibited positivity to CD68 and CD163. We evaluated the MVD and the expression of the vascular endothelial growth factor (VEGF) based on histological architecture. The MVD of all OVX cases was significantly higher than that of the corresponding normal epithelia. Interestingly, the MVD of verrucous-type OVX cases was higher than that of the other type. VEGF was expressed on foamy macrophages in all cases. Overall, the foamy macrophages expressing CD163 were associated with the morphogenesis of OVX through the process of angiogenesis by VEGF expression.https://www.mdpi.com/2304-6767/8/1/18oral verruciform xanthomafoamy macrophagecd163angiogenesisvegf |
| spellingShingle | Manabu Shigeoka Yu-ichiro Koma Takayuki Kodama Mari Nishio Masaya Akashi Hiroshi Yokozaki CD163<sup>+</sup> Foamy Macrophages Are Associated with the Morphogenesis of Oral Verruciform Xanthoma through Angiogenesis by VEGF Expression: An Immunohistochemical Study Dentistry Journal oral verruciform xanthoma foamy macrophage cd163 angiogenesis vegf |
| title | CD163<sup>+</sup> Foamy Macrophages Are Associated with the Morphogenesis of Oral Verruciform Xanthoma through Angiogenesis by VEGF Expression: An Immunohistochemical Study |
| title_full | CD163<sup>+</sup> Foamy Macrophages Are Associated with the Morphogenesis of Oral Verruciform Xanthoma through Angiogenesis by VEGF Expression: An Immunohistochemical Study |
| title_fullStr | CD163<sup>+</sup> Foamy Macrophages Are Associated with the Morphogenesis of Oral Verruciform Xanthoma through Angiogenesis by VEGF Expression: An Immunohistochemical Study |
| title_full_unstemmed | CD163<sup>+</sup> Foamy Macrophages Are Associated with the Morphogenesis of Oral Verruciform Xanthoma through Angiogenesis by VEGF Expression: An Immunohistochemical Study |
| title_short | CD163<sup>+</sup> Foamy Macrophages Are Associated with the Morphogenesis of Oral Verruciform Xanthoma through Angiogenesis by VEGF Expression: An Immunohistochemical Study |
| title_sort | cd163 sup sup foamy macrophages are associated with the morphogenesis of oral verruciform xanthoma through angiogenesis by vegf expression an immunohistochemical study |
| topic | oral verruciform xanthoma foamy macrophage cd163 angiogenesis vegf |
| url | https://www.mdpi.com/2304-6767/8/1/18 |
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