Genomic characterization of mixed lineage leukemias
Developing new technologies and genomic techniques generate big data, which is very helpful to evaluate extensively hematologic malignancies. Besides wet lab results, such as gene and microRNA expression, methylation profile, next-generation sequencing data, whole-exome and RNA-seq, FISH analysis, S...
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| Format: | Article |
| Language: | English |
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Verduci Editore
2020-03-01
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| Series: | World Cancer Research Journal |
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| Online Access: | https://www.wcrj.net/wp-content/uploads/sites/5/2020/03/e1516-Genomic-characterization-of-mixed-lineage-leukemias.pdf |
| _version_ | 1818676796015509504 |
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| author | S. Dogan |
| author_facet | S. Dogan |
| author_sort | S. Dogan |
| collection | DOAJ |
| description | Developing new technologies and genomic techniques generate big data, which is very helpful to evaluate extensively hematologic malignancies. Besides wet lab results, such as gene and microRNA expression, methylation profile, next-generation sequencing data, whole-exome and RNA-seq, FISH analysis, SNP arrays, new computer algorithm, and programs have allowed for improving the understanding transformation oncohematological disorder mechanism. In addition to that, the whole wet and dry lab results permit us to develop a new prognostic algorithm, which can assist to decide the most appropriate treatment. Furthermore, finding and analyzing new biomarkers drive the geneticists to produce therapy target and personalized medicine. The novel and effective contribution of the new technologies in the context of leukemia of both AML, Acute Myeloid Leukemia and ALL, Acute Lymphoblastic Leukemia and genomic characterization of de novo mixed-lineage leukemia are described in this review. |
| first_indexed | 2024-12-17T08:49:10Z |
| format | Article |
| id | doaj.art-ee8b920806cc4a4c990376ec0ac51870 |
| institution | Directory Open Access Journal |
| issn | 2372-3416 |
| language | English |
| last_indexed | 2024-12-17T08:49:10Z |
| publishDate | 2020-03-01 |
| publisher | Verduci Editore |
| record_format | Article |
| series | World Cancer Research Journal |
| spelling | doaj.art-ee8b920806cc4a4c990376ec0ac518702022-12-21T21:56:08ZengVerduci EditoreWorld Cancer Research Journal2372-34162020-03-01710.32113/wcrj_20203_15161516Genomic characterization of mixed lineage leukemiasS. Dogan0Peter Debye Institute, Faculty for Physics and Earth Sciences, Leipzig University, Leipzig, GermanyDeveloping new technologies and genomic techniques generate big data, which is very helpful to evaluate extensively hematologic malignancies. Besides wet lab results, such as gene and microRNA expression, methylation profile, next-generation sequencing data, whole-exome and RNA-seq, FISH analysis, SNP arrays, new computer algorithm, and programs have allowed for improving the understanding transformation oncohematological disorder mechanism. In addition to that, the whole wet and dry lab results permit us to develop a new prognostic algorithm, which can assist to decide the most appropriate treatment. Furthermore, finding and analyzing new biomarkers drive the geneticists to produce therapy target and personalized medicine. The novel and effective contribution of the new technologies in the context of leukemia of both AML, Acute Myeloid Leukemia and ALL, Acute Lymphoblastic Leukemia and genomic characterization of de novo mixed-lineage leukemia are described in this review.https://www.wcrj.net/wp-content/uploads/sites/5/2020/03/e1516-Genomic-characterization-of-mixed-lineage-leukemias.pdfmllgenomic mllgene expression and methylation of mllcharacteristics of mll |
| spellingShingle | S. Dogan Genomic characterization of mixed lineage leukemias World Cancer Research Journal mll genomic mll gene expression and methylation of mll characteristics of mll |
| title | Genomic characterization of mixed lineage leukemias |
| title_full | Genomic characterization of mixed lineage leukemias |
| title_fullStr | Genomic characterization of mixed lineage leukemias |
| title_full_unstemmed | Genomic characterization of mixed lineage leukemias |
| title_short | Genomic characterization of mixed lineage leukemias |
| title_sort | genomic characterization of mixed lineage leukemias |
| topic | mll genomic mll gene expression and methylation of mll characteristics of mll |
| url | https://www.wcrj.net/wp-content/uploads/sites/5/2020/03/e1516-Genomic-characterization-of-mixed-lineage-leukemias.pdf |
| work_keys_str_mv | AT sdogan genomiccharacterizationofmixedlineageleukemias |