Fibrosis, the Bad Actor in Cardiorenal Syndromes: Mechanisms Involved
Cardiorenal syndrome is a term that defines the complex bidirectional nature of the interaction between cardiac and renal disease. It is well established that patients with kidney disease have higher incidence of cardiovascular comorbidities and that renal dysfunction is a significant threat to the...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/7/1824 |
| _version_ | 1797527417047220224 |
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| author | Beatriz Delgado-Valero Victoria Cachofeiro Ernesto Martínez-Martínez |
| author_facet | Beatriz Delgado-Valero Victoria Cachofeiro Ernesto Martínez-Martínez |
| author_sort | Beatriz Delgado-Valero |
| collection | DOAJ |
| description | Cardiorenal syndrome is a term that defines the complex bidirectional nature of the interaction between cardiac and renal disease. It is well established that patients with kidney disease have higher incidence of cardiovascular comorbidities and that renal dysfunction is a significant threat to the prognosis of patients with cardiac disease. Fibrosis is a common characteristic of organ injury progression that has been proposed not only as a marker but also as an important driver of the pathophysiology of cardiorenal syndromes. Due to the relevance of fibrosis, its study might give insight into the mechanisms and targets that could potentially be modulated to prevent fibrosis development. The aim of this review was to summarize some of the pathophysiological pathways involved in the fibrotic damage seen in cardiorenal syndromes, such as inflammation, oxidative stress and endoplasmic reticulum stress, which are known to be triggers and mediators of fibrosis. |
| first_indexed | 2024-03-10T09:43:35Z |
| format | Article |
| id | doaj.art-ee8df8659d064afd94f8d780ebc18d43 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T09:43:35Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-ee8df8659d064afd94f8d780ebc18d432023-11-22T03:30:45ZengMDPI AGCells2073-44092021-07-01107182410.3390/cells10071824Fibrosis, the Bad Actor in Cardiorenal Syndromes: Mechanisms InvolvedBeatriz Delgado-Valero0Victoria Cachofeiro1Ernesto Martínez-Martínez2Departamento de Fisiología, Facultad de Medicina, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Universidad Complutense de Madrid, 28040 Madrid, SpainDepartamento de Fisiología, Facultad de Medicina, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Universidad Complutense de Madrid, 28040 Madrid, SpainDepartamento de Fisiología, Facultad de Medicina, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Universidad Complutense de Madrid, 28040 Madrid, SpainCardiorenal syndrome is a term that defines the complex bidirectional nature of the interaction between cardiac and renal disease. It is well established that patients with kidney disease have higher incidence of cardiovascular comorbidities and that renal dysfunction is a significant threat to the prognosis of patients with cardiac disease. Fibrosis is a common characteristic of organ injury progression that has been proposed not only as a marker but also as an important driver of the pathophysiology of cardiorenal syndromes. Due to the relevance of fibrosis, its study might give insight into the mechanisms and targets that could potentially be modulated to prevent fibrosis development. The aim of this review was to summarize some of the pathophysiological pathways involved in the fibrotic damage seen in cardiorenal syndromes, such as inflammation, oxidative stress and endoplasmic reticulum stress, which are known to be triggers and mediators of fibrosis.https://www.mdpi.com/2073-4409/10/7/1824cardiorenal syndromeendoplasmic reticulum stressfibrosisheart failureinflammationkidney disease |
| spellingShingle | Beatriz Delgado-Valero Victoria Cachofeiro Ernesto Martínez-Martínez Fibrosis, the Bad Actor in Cardiorenal Syndromes: Mechanisms Involved Cells cardiorenal syndrome endoplasmic reticulum stress fibrosis heart failure inflammation kidney disease |
| title | Fibrosis, the Bad Actor in Cardiorenal Syndromes: Mechanisms Involved |
| title_full | Fibrosis, the Bad Actor in Cardiorenal Syndromes: Mechanisms Involved |
| title_fullStr | Fibrosis, the Bad Actor in Cardiorenal Syndromes: Mechanisms Involved |
| title_full_unstemmed | Fibrosis, the Bad Actor in Cardiorenal Syndromes: Mechanisms Involved |
| title_short | Fibrosis, the Bad Actor in Cardiorenal Syndromes: Mechanisms Involved |
| title_sort | fibrosis the bad actor in cardiorenal syndromes mechanisms involved |
| topic | cardiorenal syndrome endoplasmic reticulum stress fibrosis heart failure inflammation kidney disease |
| url | https://www.mdpi.com/2073-4409/10/7/1824 |
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