Twelve-Week Mediterranean Diet Intervention Increases Citrus Bioflavonoid Levels and Reduces Inflammation in People with Type 2 Diabetes Mellitus
The benefits of a Mediterranean Diet (MedDiet) in the management of diabetes have been reported, but the contribution of polyphenol-rich citrus fruit has not been studied widely. Here, we report the sub-study findings of a previously conducted MedDiet intervention clinical trial in patients with typ...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-03-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/13/4/1133 |
| _version_ | 1797539584695861248 |
|---|---|
| author | Hayder A. Al-Aubaidy Aanchal Dayan Myrna A. Deseo Catherine Itsiopoulos Dina Jamil Najah R. Hadi Colleen J. Thomas |
| author_facet | Hayder A. Al-Aubaidy Aanchal Dayan Myrna A. Deseo Catherine Itsiopoulos Dina Jamil Najah R. Hadi Colleen J. Thomas |
| author_sort | Hayder A. Al-Aubaidy |
| collection | DOAJ |
| description | The benefits of a Mediterranean Diet (MedDiet) in the management of diabetes have been reported, but the contribution of polyphenol-rich citrus fruit has not been studied widely. Here, we report the sub-study findings of a previously conducted MedDiet intervention clinical trial in patients with type 2 diabetes mellitus (T2DM), where we aimed to measure the diet intervention effects on plasma citrus bioflavonoids levels and biomarkers of inflammation and oxidative stress. We analysed plasma samples from 19 (of original 27) participants with T2DM who were randomly assigned to consume the MedDiet intervention or their usual diet for 12 weeks and then crossed over to the alternate diet. Compared with baseline, MedDiet significantly increased levels of the citrus bioflavonoids naringin, hesperitin and hesperidin (by 60%, 58% and 39%, respectively, <i>p</i> < 0.05) and reduced plasma levels of the pro-inflammatory cytokine IL-6 (by 49%, <i>p</i> = 0.016). Oxidative stress marker 8-hydroxy-2′-deoxyguanosine (8-OHdG) decreased by 32.4% (<i>p</i> = 0.128). Usual diet did not induce these beneficial changes. The reduced inflammatory profile of T2DM participants may, in part, be attributed to the anti-inflammatory actions of citrus bioflavonoids. Together with indications of improved oxidative stress, these findings add to the scientific evidence base for beneficial consumption of citrus fruit in the MedDiet pattern. |
| first_indexed | 2024-03-10T12:47:56Z |
| format | Article |
| id | doaj.art-ee905fbb24a2416baba41b164e4886fa |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T12:47:56Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-ee905fbb24a2416baba41b164e4886fa2023-11-21T13:23:00ZengMDPI AGNutrients2072-66432021-03-01134113310.3390/nu13041133Twelve-Week Mediterranean Diet Intervention Increases Citrus Bioflavonoid Levels and Reduces Inflammation in People with Type 2 Diabetes MellitusHayder A. Al-Aubaidy0Aanchal Dayan1Myrna A. Deseo2Catherine Itsiopoulos3Dina Jamil4Najah R. Hadi5Colleen J. Thomas6Department of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Melbourne 3086, AustraliaDepartment of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Melbourne 3086, AustraliaARC Research Hub for Medicinal Agriculture, La Trobe Institute for Agriculture and Food, Department of Animal, Plant and Soil Sciences, School of Life Sciences, La Trobe University, Melbourne 3086, AustraliaSchool of Allied Health, Human Services and Sport, La Trobe University, Melbourne 3086, AustraliaDepartment of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Melbourne 3086, AustraliaDepartment of Pharmacology and Therapeutics, Faculty of Medicine, University of Kufa, Al-Najaf 0054, IraqDepartment of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Melbourne 3086, AustraliaThe benefits of a Mediterranean Diet (MedDiet) in the management of diabetes have been reported, but the contribution of polyphenol-rich citrus fruit has not been studied widely. Here, we report the sub-study findings of a previously conducted MedDiet intervention clinical trial in patients with type 2 diabetes mellitus (T2DM), where we aimed to measure the diet intervention effects on plasma citrus bioflavonoids levels and biomarkers of inflammation and oxidative stress. We analysed plasma samples from 19 (of original 27) participants with T2DM who were randomly assigned to consume the MedDiet intervention or their usual diet for 12 weeks and then crossed over to the alternate diet. Compared with baseline, MedDiet significantly increased levels of the citrus bioflavonoids naringin, hesperitin and hesperidin (by 60%, 58% and 39%, respectively, <i>p</i> < 0.05) and reduced plasma levels of the pro-inflammatory cytokine IL-6 (by 49%, <i>p</i> = 0.016). Oxidative stress marker 8-hydroxy-2′-deoxyguanosine (8-OHdG) decreased by 32.4% (<i>p</i> = 0.128). Usual diet did not induce these beneficial changes. The reduced inflammatory profile of T2DM participants may, in part, be attributed to the anti-inflammatory actions of citrus bioflavonoids. Together with indications of improved oxidative stress, these findings add to the scientific evidence base for beneficial consumption of citrus fruit in the MedDiet pattern.https://www.mdpi.com/2072-6643/13/4/1133type 2 diabetes mellitusdipeptidyl peptidase-4citrus bioflavonoidsoxidative stressinflammation |
| spellingShingle | Hayder A. Al-Aubaidy Aanchal Dayan Myrna A. Deseo Catherine Itsiopoulos Dina Jamil Najah R. Hadi Colleen J. Thomas Twelve-Week Mediterranean Diet Intervention Increases Citrus Bioflavonoid Levels and Reduces Inflammation in People with Type 2 Diabetes Mellitus Nutrients type 2 diabetes mellitus dipeptidyl peptidase-4 citrus bioflavonoids oxidative stress inflammation |
| title | Twelve-Week Mediterranean Diet Intervention Increases Citrus Bioflavonoid Levels and Reduces Inflammation in People with Type 2 Diabetes Mellitus |
| title_full | Twelve-Week Mediterranean Diet Intervention Increases Citrus Bioflavonoid Levels and Reduces Inflammation in People with Type 2 Diabetes Mellitus |
| title_fullStr | Twelve-Week Mediterranean Diet Intervention Increases Citrus Bioflavonoid Levels and Reduces Inflammation in People with Type 2 Diabetes Mellitus |
| title_full_unstemmed | Twelve-Week Mediterranean Diet Intervention Increases Citrus Bioflavonoid Levels and Reduces Inflammation in People with Type 2 Diabetes Mellitus |
| title_short | Twelve-Week Mediterranean Diet Intervention Increases Citrus Bioflavonoid Levels and Reduces Inflammation in People with Type 2 Diabetes Mellitus |
| title_sort | twelve week mediterranean diet intervention increases citrus bioflavonoid levels and reduces inflammation in people with type 2 diabetes mellitus |
| topic | type 2 diabetes mellitus dipeptidyl peptidase-4 citrus bioflavonoids oxidative stress inflammation |
| url | https://www.mdpi.com/2072-6643/13/4/1133 |
| work_keys_str_mv | AT hayderaalaubaidy twelveweekmediterraneandietinterventionincreasescitrusbioflavonoidlevelsandreducesinflammationinpeoplewithtype2diabetesmellitus AT aanchaldayan twelveweekmediterraneandietinterventionincreasescitrusbioflavonoidlevelsandreducesinflammationinpeoplewithtype2diabetesmellitus AT myrnaadeseo twelveweekmediterraneandietinterventionincreasescitrusbioflavonoidlevelsandreducesinflammationinpeoplewithtype2diabetesmellitus AT catherineitsiopoulos twelveweekmediterraneandietinterventionincreasescitrusbioflavonoidlevelsandreducesinflammationinpeoplewithtype2diabetesmellitus AT dinajamil twelveweekmediterraneandietinterventionincreasescitrusbioflavonoidlevelsandreducesinflammationinpeoplewithtype2diabetesmellitus AT najahrhadi twelveweekmediterraneandietinterventionincreasescitrusbioflavonoidlevelsandreducesinflammationinpeoplewithtype2diabetesmellitus AT colleenjthomas twelveweekmediterraneandietinterventionincreasescitrusbioflavonoidlevelsandreducesinflammationinpeoplewithtype2diabetesmellitus |