Affinity of Propofol to Human Serum Albumin and Cardiovascular Effects
Propofol is used in general anesthesia and sedation. İt is an lipofilic agent and metabolize to inactive form in liver then excreted in the urine. In body it is turnover changes by human serum albumin amount. >97% of propofol is bound to serum albumin. So that hypoalbunemia changes propofol effec...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Turkish Science and Technology Publishing (TURSTEP)
2019-04-01
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| Series: | Turkish Journal of Agriculture: Food Science and Technology |
| Subjects: | |
| Online Access: | http://www.agrifoodscience.com/index.php/TURJAF/article/view/2486 |
| _version_ | 1797914708099989504 |
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| author | Betül Özaltun Zeliha Selamoğlu |
| author_facet | Betül Özaltun Zeliha Selamoğlu |
| author_sort | Betül Özaltun |
| collection | DOAJ |
| description | Propofol is used in general anesthesia and sedation. İt is an lipofilic agent and metabolize to inactive form in liver then excreted in the urine. In body it is turnover changes by human serum albumin amount. >97% of propofol is bound to serum albumin. So that hypoalbunemia changes propofol effects. Free form of propopol can pass all membrans such as the blood-brain barrier and the cellular membrane of the cardiac endothelium. Propofol may cause significant myocardial depression, decrease blood pressure and cause life threatining arytmias. Changes in the ratio of free and bound forms of propofol and albumin depending on the dose and duration of administration, the effects of this ratio on cardiac profile are discussed in this study. According to the findings, it was determined that the albumin affinity of propofol decreased in all dose groups in time. Since free HSA and free propofol ratio will increase, this situation is thought to affect the cardiac profile negatively. |
| first_indexed | 2024-04-10T12:30:21Z |
| format | Article |
| id | doaj.art-ee9217bceb6b4a529d2b8564d0ae7537 |
| institution | Directory Open Access Journal |
| issn | 2148-127X |
| language | English |
| last_indexed | 2024-04-10T12:30:21Z |
| publishDate | 2019-04-01 |
| publisher | Turkish Science and Technology Publishing (TURSTEP) |
| record_format | Article |
| series | Turkish Journal of Agriculture: Food Science and Technology |
| spelling | doaj.art-ee9217bceb6b4a529d2b8564d0ae75372023-02-15T16:14:58ZengTurkish Science and Technology Publishing (TURSTEP)Turkish Journal of Agriculture: Food Science and Technology2148-127X2019-04-017468468710.24925/turjaf.v7i4.684-687.24861135Affinity of Propofol to Human Serum Albumin and Cardiovascular EffectsBetül Özaltun0Zeliha Selamoğlu1Department of Cardiology Faculty of Medicine, Niğde Ömer Halisdemir University, 51240Department of Medical Biology, Faculty of Medicine, Niğde Ömer Halisdemir University, 51240 NiğdePropofol is used in general anesthesia and sedation. İt is an lipofilic agent and metabolize to inactive form in liver then excreted in the urine. In body it is turnover changes by human serum albumin amount. >97% of propofol is bound to serum albumin. So that hypoalbunemia changes propofol effects. Free form of propopol can pass all membrans such as the blood-brain barrier and the cellular membrane of the cardiac endothelium. Propofol may cause significant myocardial depression, decrease blood pressure and cause life threatining arytmias. Changes in the ratio of free and bound forms of propofol and albumin depending on the dose and duration of administration, the effects of this ratio on cardiac profile are discussed in this study. According to the findings, it was determined that the albumin affinity of propofol decreased in all dose groups in time. Since free HSA and free propofol ratio will increase, this situation is thought to affect the cardiac profile negatively.http://www.agrifoodscience.com/index.php/TURJAF/article/view/2486propofolhuman serum albumincardiovascularanesthesiahypotension |
| spellingShingle | Betül Özaltun Zeliha Selamoğlu Affinity of Propofol to Human Serum Albumin and Cardiovascular Effects Turkish Journal of Agriculture: Food Science and Technology propofol human serum albumin cardiovascular anesthesia hypotension |
| title | Affinity of Propofol to Human Serum Albumin and Cardiovascular Effects |
| title_full | Affinity of Propofol to Human Serum Albumin and Cardiovascular Effects |
| title_fullStr | Affinity of Propofol to Human Serum Albumin and Cardiovascular Effects |
| title_full_unstemmed | Affinity of Propofol to Human Serum Albumin and Cardiovascular Effects |
| title_short | Affinity of Propofol to Human Serum Albumin and Cardiovascular Effects |
| title_sort | affinity of propofol to human serum albumin and cardiovascular effects |
| topic | propofol human serum albumin cardiovascular anesthesia hypotension |
| url | http://www.agrifoodscience.com/index.php/TURJAF/article/view/2486 |
| work_keys_str_mv | AT betulozaltun affinityofpropofoltohumanserumalbuminandcardiovasculareffects AT zelihaselamoglu affinityofpropofoltohumanserumalbuminandcardiovasculareffects |