Molecular basis of Rh blood group system in the Malaysian population
Background: Rh molecular studies have been previously mainly conducted in Caucasians and African population. There is a limited data on the molecular basis for Rh genotypes among Asians. Aims: This study aims to characterize the Rh genes and frequency of the various RH genotypes among blood donors i...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Asian Journal of Transfusion Science |
| Subjects: | |
| Online Access: | http://www.ajts.org/article.asp?issn=0973-6247;year=2015;volume=9;issue=1;spage=48;epage=54;aulast=Musa |
| _version_ | 1819037330223136768 |
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| author | Rozi Hanisa Musa Nor Asiah Muhamad Afifah Hassan Yasmin Ayob Narazah Mohd Yusoff |
| author_facet | Rozi Hanisa Musa Nor Asiah Muhamad Afifah Hassan Yasmin Ayob Narazah Mohd Yusoff |
| author_sort | Rozi Hanisa Musa |
| collection | DOAJ |
| description | Background: Rh molecular studies have been previously mainly conducted in Caucasians and African population. There is a limited data on the molecular basis for Rh genotypes among Asians. Aims: This study aims to characterize the Rh genes and frequency of the various RH genotypes among blood donors in National Blood Centre (NBC), Kuala Lumpur. Materials and Methods: A total of 1014 blood samples were obtained from blood donors from four different ethnic groups (360 Malays, 434 Chinese, 164 Indians and 56 others). Serological and molecular analysis of all 1014 blood samples were performed. An automated deoxyribonucleic acid sequencing analysis was performed. Results: Rh phenotypes and RH genotypes showed heterogeneity and significant association with ethnicities. Discrepancies in allele D, C/c and E/e between phenotypes and genotypes results were observed. Discrepancy results in allele D showed significant association with the ethnic groups of the blood donors in NBC. There were multiple novel mutations (23) and published mutations (5) found in this study. Significant associations between discrepancy results and mutations were found in allele D and C/c. Conclusion: Performing RH molecular analysis in Malaysian population provided the basic database for the distribution of Rh genotypes of donors from major ethnic groups in Malaysia. |
| first_indexed | 2024-12-21T08:19:42Z |
| format | Article |
| id | doaj.art-ee926c174e2a42b9a649834ff63aec46 |
| institution | Directory Open Access Journal |
| issn | 0973-6247 1998-3565 |
| language | English |
| last_indexed | 2024-12-21T08:19:42Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Transfusion Science |
| spelling | doaj.art-ee926c174e2a42b9a649834ff63aec462022-12-21T19:10:28ZengWolters Kluwer Medknow PublicationsAsian Journal of Transfusion Science0973-62471998-35652015-01-0191485410.4103/0973-6247.150951Molecular basis of Rh blood group system in the Malaysian populationRozi Hanisa MusaNor Asiah MuhamadAfifah HassanYasmin AyobNarazah Mohd YusoffBackground: Rh molecular studies have been previously mainly conducted in Caucasians and African population. There is a limited data on the molecular basis for Rh genotypes among Asians. Aims: This study aims to characterize the Rh genes and frequency of the various RH genotypes among blood donors in National Blood Centre (NBC), Kuala Lumpur. Materials and Methods: A total of 1014 blood samples were obtained from blood donors from four different ethnic groups (360 Malays, 434 Chinese, 164 Indians and 56 others). Serological and molecular analysis of all 1014 blood samples were performed. An automated deoxyribonucleic acid sequencing analysis was performed. Results: Rh phenotypes and RH genotypes showed heterogeneity and significant association with ethnicities. Discrepancies in allele D, C/c and E/e between phenotypes and genotypes results were observed. Discrepancy results in allele D showed significant association with the ethnic groups of the blood donors in NBC. There were multiple novel mutations (23) and published mutations (5) found in this study. Significant associations between discrepancy results and mutations were found in allele D and C/c. Conclusion: Performing RH molecular analysis in Malaysian population provided the basic database for the distribution of Rh genotypes of donors from major ethnic groups in Malaysia.http://www.ajts.org/article.asp?issn=0973-6247;year=2015;volume=9;issue=1;spage=48;epage=54;aulast=MusaAlleleRh genotypesRh molecularRh phenotypes |
| spellingShingle | Rozi Hanisa Musa Nor Asiah Muhamad Afifah Hassan Yasmin Ayob Narazah Mohd Yusoff Molecular basis of Rh blood group system in the Malaysian population Asian Journal of Transfusion Science Allele Rh genotypes Rh molecular Rh phenotypes |
| title | Molecular basis of Rh blood group system in the Malaysian population |
| title_full | Molecular basis of Rh blood group system in the Malaysian population |
| title_fullStr | Molecular basis of Rh blood group system in the Malaysian population |
| title_full_unstemmed | Molecular basis of Rh blood group system in the Malaysian population |
| title_short | Molecular basis of Rh blood group system in the Malaysian population |
| title_sort | molecular basis of rh blood group system in the malaysian population |
| topic | Allele Rh genotypes Rh molecular Rh phenotypes |
| url | http://www.ajts.org/article.asp?issn=0973-6247;year=2015;volume=9;issue=1;spage=48;epage=54;aulast=Musa |
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