The Study of Clinical and Biochemical Parameters in Assessing the Response to the Antiviral Therapy in the Chronic Viral Hepatitis B
<i>Background and Objectives</i>: Hepatitis B virus infection remains a major public health concern. The interaction between hepatitis B virus (HBV) hepatitis B virus and the host inflammatory response is an important contributing factor driving liver damage and diseases outcomes. The ma...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/57/8/757 |
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| author | Alice Elena Ghenea Vlad Pădureanu Ramona Cioboată Anca-Loredana Udriștoiu Andrei Ioan Drocaş Eugen Țieranu Mara Carsote Corina Maria Vasile Aritina Moroşanu Viorel Biciușcă Alex-Ioan Salan Adriana Turculeanu Anca Ungureanu |
| author_facet | Alice Elena Ghenea Vlad Pădureanu Ramona Cioboată Anca-Loredana Udriștoiu Andrei Ioan Drocaş Eugen Țieranu Mara Carsote Corina Maria Vasile Aritina Moroşanu Viorel Biciușcă Alex-Ioan Salan Adriana Turculeanu Anca Ungureanu |
| author_sort | Alice Elena Ghenea |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Hepatitis B virus infection remains a major public health concern. The interaction between hepatitis B virus (HBV) hepatitis B virus and the host inflammatory response is an important contributing factor driving liver damage and diseases outcomes. The management of chronic hepatitis B virus infection is an area of massive unmet clinical need worldwide. Our primary aim for this study was to evaluate biological response rates and sustained virological response in patients with chronic hepatitis B treated with Peg-IFN α-2a/b. The second aim of the study was the identification of metabolic changes and insulin resistance. <i>Materials and Methods</i>: We enrolled in this study 166 patients who fulfilled all inclusion and exclusion criteria. These treatment-naive patients with chronic HBV were treated with Pegylated Interferon α-2a/b. HBV infection was defined by the presence of HBV serological markers (HBsAg, anti-HBsAb, anti-HBcAb, HBeAg, anti HBeAb) by Enzyme-Linked Immuno Sorbent Assay (ELISA) and serum HBV-DNA levels were estimated by a commercially available quantitative polymerase chain reaction (PCR) assay. <i>Results</i>: Patients’ recovery progress has been evaluated by determining the following: age, gender; biochemical tests; alanine aminotransferase, aspartate aminotransferase; serological assays for HBV serological markers (HBsAg, anti-HBsAc/Ab, anti-HBcAc/Ab, HBeAg, anti HBeAc/Ab); molecular tests to detect viral particles, testing for HBV DNA (PCR) to confirm the diagnosis and quantify the number of viral copies in the blood (viremia); liver ultrasound—performed through epigastric and intercostal approach (transversal and longitudinal sections). <i>Conclusions</i>: Our results indicated that only HOMA index values, that of fasting insulin, together with baseline HBV DNA, alanine aminotransferase values, mean blood glucose at the beginning of treatment may be predictive of the early viral response in chronic hepatitis B. |
| first_indexed | 2024-03-10T08:37:36Z |
| format | Article |
| id | doaj.art-ee936c7e31664441b3f4f76a29785da2 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T08:37:36Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-ee936c7e31664441b3f4f76a29785da22023-11-22T08:35:39ZengMDPI AGMedicina1010-660X1648-91442021-07-0157875710.3390/medicina57080757The Study of Clinical and Biochemical Parameters in Assessing the Response to the Antiviral Therapy in the Chronic Viral Hepatitis BAlice Elena Ghenea0Vlad Pădureanu1Ramona Cioboată2Anca-Loredana Udriștoiu3Andrei Ioan Drocaş4Eugen Țieranu5Mara Carsote6Corina Maria Vasile7Aritina Moroşanu8Viorel Biciușcă9Alex-Ioan Salan10Adriana Turculeanu11Anca Ungureanu12Department of Bacteriology-Virology-Parasitology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Internal Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Pneumology, University of Pharmacy and Medicine Craiova, 200349 Craiova, RomaniaFaculty of Automation, Computers and Electronics, University of Craiova, 200776 Craiova, RomaniaDepartment of Urology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Cardiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Endocrinology, C.I. Parhon National Institute of Endocrinology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Pediatric Cardiology, County Clinical Emergency Hospital of Craiova, 200349 Craiova, RomaniaDepartment of Paediatrics, University of Medicine and Pharmacy Craiova, 200349 Craiova, RomaniaDepartment of Internal Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Oral and Maxillofacial Surgery, University of Medicine and Pharmacy Craiova, 200349 Craiova, RomaniaDepartment of Bacteriology-Virology-Parasitology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Bacteriology-Virology-Parasitology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania<i>Background and Objectives</i>: Hepatitis B virus infection remains a major public health concern. The interaction between hepatitis B virus (HBV) hepatitis B virus and the host inflammatory response is an important contributing factor driving liver damage and diseases outcomes. The management of chronic hepatitis B virus infection is an area of massive unmet clinical need worldwide. Our primary aim for this study was to evaluate biological response rates and sustained virological response in patients with chronic hepatitis B treated with Peg-IFN α-2a/b. The second aim of the study was the identification of metabolic changes and insulin resistance. <i>Materials and Methods</i>: We enrolled in this study 166 patients who fulfilled all inclusion and exclusion criteria. These treatment-naive patients with chronic HBV were treated with Pegylated Interferon α-2a/b. HBV infection was defined by the presence of HBV serological markers (HBsAg, anti-HBsAb, anti-HBcAb, HBeAg, anti HBeAb) by Enzyme-Linked Immuno Sorbent Assay (ELISA) and serum HBV-DNA levels were estimated by a commercially available quantitative polymerase chain reaction (PCR) assay. <i>Results</i>: Patients’ recovery progress has been evaluated by determining the following: age, gender; biochemical tests; alanine aminotransferase, aspartate aminotransferase; serological assays for HBV serological markers (HBsAg, anti-HBsAc/Ab, anti-HBcAc/Ab, HBeAg, anti HBeAc/Ab); molecular tests to detect viral particles, testing for HBV DNA (PCR) to confirm the diagnosis and quantify the number of viral copies in the blood (viremia); liver ultrasound—performed through epigastric and intercostal approach (transversal and longitudinal sections). <i>Conclusions</i>: Our results indicated that only HOMA index values, that of fasting insulin, together with baseline HBV DNA, alanine aminotransferase values, mean blood glucose at the beginning of treatment may be predictive of the early viral response in chronic hepatitis B.https://www.mdpi.com/1648-9144/57/8/757antiviral therapychronic hepatitis Binterferon-alpha α-2a/b |
| spellingShingle | Alice Elena Ghenea Vlad Pădureanu Ramona Cioboată Anca-Loredana Udriștoiu Andrei Ioan Drocaş Eugen Țieranu Mara Carsote Corina Maria Vasile Aritina Moroşanu Viorel Biciușcă Alex-Ioan Salan Adriana Turculeanu Anca Ungureanu The Study of Clinical and Biochemical Parameters in Assessing the Response to the Antiviral Therapy in the Chronic Viral Hepatitis B Medicina antiviral therapy chronic hepatitis B interferon-alpha α-2a/b |
| title | The Study of Clinical and Biochemical Parameters in Assessing the Response to the Antiviral Therapy in the Chronic Viral Hepatitis B |
| title_full | The Study of Clinical and Biochemical Parameters in Assessing the Response to the Antiviral Therapy in the Chronic Viral Hepatitis B |
| title_fullStr | The Study of Clinical and Biochemical Parameters in Assessing the Response to the Antiviral Therapy in the Chronic Viral Hepatitis B |
| title_full_unstemmed | The Study of Clinical and Biochemical Parameters in Assessing the Response to the Antiviral Therapy in the Chronic Viral Hepatitis B |
| title_short | The Study of Clinical and Biochemical Parameters in Assessing the Response to the Antiviral Therapy in the Chronic Viral Hepatitis B |
| title_sort | study of clinical and biochemical parameters in assessing the response to the antiviral therapy in the chronic viral hepatitis b |
| topic | antiviral therapy chronic hepatitis B interferon-alpha α-2a/b |
| url | https://www.mdpi.com/1648-9144/57/8/757 |
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