Mechanical adaptation of trabecular bone morphology in the mammalian mandible
Abstract Alveolar bone, together with the underlying trabecular bone, fulfils an important role in providing structural support against masticatory forces. Diseases such as osteoporosis or periodontitis cause alveolar bone resorption which weakens this structural support and is a major cause of toot...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2018-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-018-25597-0 |
| _version_ | 1830301540972232704 |
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| author | Peter J. Watson Laura C. Fitton Carlo Meloro Michael J. Fagan Flora Gröning |
| author_facet | Peter J. Watson Laura C. Fitton Carlo Meloro Michael J. Fagan Flora Gröning |
| author_sort | Peter J. Watson |
| collection | DOAJ |
| description | Abstract Alveolar bone, together with the underlying trabecular bone, fulfils an important role in providing structural support against masticatory forces. Diseases such as osteoporosis or periodontitis cause alveolar bone resorption which weakens this structural support and is a major cause of tooth loss. However, the functional relationship between alveolar bone remodelling within the molar region and masticatory forces is not well understood. This study investigated this relationship by comparing mammalian species with different diets and functional loading (Felis catus, Cercocebus atys, Homo sapiens, Sus scrofa, Oryctolagus cuniculus, Ovis aries). We performed histomorphometric analyses of trabecular bone morphology (bone volume fraction, trabecular thickness and trabecular spacing) and quantified the variation of bone and tooth root volumes along the tooth row. A principal component analysis and non-parametric MANOVA showed statistically significant differences in trabecular bone morphology between species with contrasting functional loading, but these differences were not seen in sub-adult specimens. Our results support a strong, but complex link between masticatory function and trabecular bone morphology. Further understanding of a potential functional relationship could aid the diagnosis and treatment of mandibular diseases causing alveolar bone resorption, and guide the design and evaluation of dental implants. |
| first_indexed | 2024-12-19T08:50:27Z |
| format | Article |
| id | doaj.art-ee93b7ffd5004b2f91d13cfb39f7ae6e |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T08:50:27Z |
| publishDate | 2018-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-ee93b7ffd5004b2f91d13cfb39f7ae6e2022-12-21T20:28:44ZengNature PortfolioScientific Reports2045-23222018-05-018111210.1038/s41598-018-25597-0Mechanical adaptation of trabecular bone morphology in the mammalian mandiblePeter J. Watson0Laura C. Fitton1Carlo Meloro2Michael J. Fagan3Flora Gröning4Medical and Biological Engineering Research Group, School of Engineering and Computer Science, University of HullCentre for Anatomical and Human Sciences, Department of Archaeology and Hull York Medical School, University of YorkResearch Centre in Evolutionary Anthropology and Palaeoecology, School of Natural Sciences and Psychology, Liverpool John Moores UniversityMedical and Biological Engineering Research Group, School of Engineering and Computer Science, University of HullArthritis and Musculoskeletal Medicine Research Programme, School of Medicine, Medical Sciences and Nutrition, University of AberdeenAbstract Alveolar bone, together with the underlying trabecular bone, fulfils an important role in providing structural support against masticatory forces. Diseases such as osteoporosis or periodontitis cause alveolar bone resorption which weakens this structural support and is a major cause of tooth loss. However, the functional relationship between alveolar bone remodelling within the molar region and masticatory forces is not well understood. This study investigated this relationship by comparing mammalian species with different diets and functional loading (Felis catus, Cercocebus atys, Homo sapiens, Sus scrofa, Oryctolagus cuniculus, Ovis aries). We performed histomorphometric analyses of trabecular bone morphology (bone volume fraction, trabecular thickness and trabecular spacing) and quantified the variation of bone and tooth root volumes along the tooth row. A principal component analysis and non-parametric MANOVA showed statistically significant differences in trabecular bone morphology between species with contrasting functional loading, but these differences were not seen in sub-adult specimens. Our results support a strong, but complex link between masticatory function and trabecular bone morphology. Further understanding of a potential functional relationship could aid the diagnosis and treatment of mandibular diseases causing alveolar bone resorption, and guide the design and evaluation of dental implants.https://doi.org/10.1038/s41598-018-25597-0 |
| spellingShingle | Peter J. Watson Laura C. Fitton Carlo Meloro Michael J. Fagan Flora Gröning Mechanical adaptation of trabecular bone morphology in the mammalian mandible Scientific Reports |
| title | Mechanical adaptation of trabecular bone morphology in the mammalian mandible |
| title_full | Mechanical adaptation of trabecular bone morphology in the mammalian mandible |
| title_fullStr | Mechanical adaptation of trabecular bone morphology in the mammalian mandible |
| title_full_unstemmed | Mechanical adaptation of trabecular bone morphology in the mammalian mandible |
| title_short | Mechanical adaptation of trabecular bone morphology in the mammalian mandible |
| title_sort | mechanical adaptation of trabecular bone morphology in the mammalian mandible |
| url | https://doi.org/10.1038/s41598-018-25597-0 |
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