Long Non-Coding RNAs (lncRNAs) as Regulators of the PI3K/AKT/mTOR Pathway in Gastric Carcinoma
Gastric cancer (GC) represents ~10% of the global cancer-related deaths, increasingly affecting the younger population in active stages of life. The high mortality of GC is due to late diagnosis, the presence of metastasis and drug resistance development. Additionally, current clinical markers do no...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/7/6294 |
| _version_ | 1797607846448201728 |
|---|---|
| author | Ismael Riquelme Pablo Pérez-Moreno Bárbara Mora-Lagos Carmen Ili Priscilla Brebi Juan Carlos Roa |
| author_facet | Ismael Riquelme Pablo Pérez-Moreno Bárbara Mora-Lagos Carmen Ili Priscilla Brebi Juan Carlos Roa |
| author_sort | Ismael Riquelme |
| collection | DOAJ |
| description | Gastric cancer (GC) represents ~10% of the global cancer-related deaths, increasingly affecting the younger population in active stages of life. The high mortality of GC is due to late diagnosis, the presence of metastasis and drug resistance development. Additionally, current clinical markers do not guide the patient management adequately, thereby new and more reliable biomarkers and therapeutic targets are still needed for this disease. RNA-seq technology has allowed the discovery of new types of RNA transcripts including long non-coding RNAs (lncRNAs), which are able to regulate the gene/protein expression of many signaling pathways (e.g., the PI3K/AKT/mTOR pathway) in cancer cells by diverse molecular mechanisms. In addition, these lncRNAs might also be proposed as promising diagnostic or prognostic biomarkers or as potential therapeutic targets in GC. This review describes important topics about some lncRNAs that have been described as regulators of the PI3K/AKT/mTOR signaling pathway, and hence, their potential oncogenic role in the development of this malignancy. |
| first_indexed | 2024-03-11T05:36:21Z |
| format | Article |
| id | doaj.art-ee95540a362a4d3ab33e5ed14987aed4 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T05:36:21Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ee95540a362a4d3ab33e5ed14987aed42023-11-17T16:49:07ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-03-01247629410.3390/ijms24076294Long Non-Coding RNAs (lncRNAs) as Regulators of the PI3K/AKT/mTOR Pathway in Gastric CarcinomaIsmael Riquelme0Pablo Pérez-Moreno1Bárbara Mora-Lagos2Carmen Ili3Priscilla Brebi4Juan Carlos Roa5Institute of Biomedical Sciences, Faculty of Health Sciences, Universidad Autónoma de Chile, Temuco 4810101, ChileMillennium Institute on Immunology and Immunotherapy (MIII), Center for Cancer Prevention and Control (CECAN), Department of Pathology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago 8380000, ChileInstitute of Biomedical Sciences, Faculty of Health Sciences, Universidad Autónoma de Chile, Temuco 4810101, ChileMillennium Institute on Immunology and Immunotherapy (MIII), Laboratory of Integrative Biology (LIBi), Center for Excellence in Translational Medicine—Scientific and Technological Bioresource Nucleus (CEMT-BIOREN), Universidad de La Frontera, Temuco 4810296, ChileMillennium Institute on Immunology and Immunotherapy (MIII), Laboratory of Integrative Biology (LIBi), Center for Excellence in Translational Medicine—Scientific and Technological Bioresource Nucleus (CEMT-BIOREN), Universidad de La Frontera, Temuco 4810296, ChileMillennium Institute on Immunology and Immunotherapy (MIII), Center for Cancer Prevention and Control (CECAN), Department of Pathology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago 8380000, ChileGastric cancer (GC) represents ~10% of the global cancer-related deaths, increasingly affecting the younger population in active stages of life. The high mortality of GC is due to late diagnosis, the presence of metastasis and drug resistance development. Additionally, current clinical markers do not guide the patient management adequately, thereby new and more reliable biomarkers and therapeutic targets are still needed for this disease. RNA-seq technology has allowed the discovery of new types of RNA transcripts including long non-coding RNAs (lncRNAs), which are able to regulate the gene/protein expression of many signaling pathways (e.g., the PI3K/AKT/mTOR pathway) in cancer cells by diverse molecular mechanisms. In addition, these lncRNAs might also be proposed as promising diagnostic or prognostic biomarkers or as potential therapeutic targets in GC. This review describes important topics about some lncRNAs that have been described as regulators of the PI3K/AKT/mTOR signaling pathway, and hence, their potential oncogenic role in the development of this malignancy.https://www.mdpi.com/1422-0067/24/7/6294gastric cancer (GC)long non-coding RNAs (lncRNAs)PI3K/AKT/mTOR signaling pathway |
| spellingShingle | Ismael Riquelme Pablo Pérez-Moreno Bárbara Mora-Lagos Carmen Ili Priscilla Brebi Juan Carlos Roa Long Non-Coding RNAs (lncRNAs) as Regulators of the PI3K/AKT/mTOR Pathway in Gastric Carcinoma International Journal of Molecular Sciences gastric cancer (GC) long non-coding RNAs (lncRNAs) PI3K/AKT/mTOR signaling pathway |
| title | Long Non-Coding RNAs (lncRNAs) as Regulators of the PI3K/AKT/mTOR Pathway in Gastric Carcinoma |
| title_full | Long Non-Coding RNAs (lncRNAs) as Regulators of the PI3K/AKT/mTOR Pathway in Gastric Carcinoma |
| title_fullStr | Long Non-Coding RNAs (lncRNAs) as Regulators of the PI3K/AKT/mTOR Pathway in Gastric Carcinoma |
| title_full_unstemmed | Long Non-Coding RNAs (lncRNAs) as Regulators of the PI3K/AKT/mTOR Pathway in Gastric Carcinoma |
| title_short | Long Non-Coding RNAs (lncRNAs) as Regulators of the PI3K/AKT/mTOR Pathway in Gastric Carcinoma |
| title_sort | long non coding rnas lncrnas as regulators of the pi3k akt mtor pathway in gastric carcinoma |
| topic | gastric cancer (GC) long non-coding RNAs (lncRNAs) PI3K/AKT/mTOR signaling pathway |
| url | https://www.mdpi.com/1422-0067/24/7/6294 |
| work_keys_str_mv | AT ismaelriquelme longnoncodingrnaslncrnasasregulatorsofthepi3kaktmtorpathwayingastriccarcinoma AT pabloperezmoreno longnoncodingrnaslncrnasasregulatorsofthepi3kaktmtorpathwayingastriccarcinoma AT barbaramoralagos longnoncodingrnaslncrnasasregulatorsofthepi3kaktmtorpathwayingastriccarcinoma AT carmenili longnoncodingrnaslncrnasasregulatorsofthepi3kaktmtorpathwayingastriccarcinoma AT priscillabrebi longnoncodingrnaslncrnasasregulatorsofthepi3kaktmtorpathwayingastriccarcinoma AT juancarlosroa longnoncodingrnaslncrnasasregulatorsofthepi3kaktmtorpathwayingastriccarcinoma |