Cribriform pattern in prostate tissues: Predictor for intraductal carcinoma of the prostate based on biopsy and radical prostatectomy pathology
Abstract Objectives This study aims to investigate whether a cribriform pattern on prostate biopsy may be a factor in suspicion of intraductal carcinoma of the prostate after radical prostatectomy. Methods This retrospective study assessed 100 men who underwent prostatectomy from 2015 to 2019. Parti...
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| Format: | Article |
| Language: | English |
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Wiley
2023-05-01
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| Series: | BJUI Compass |
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| Online Access: | https://doi.org/10.1002/bco2.201 |
| _version_ | 1797852951490854912 |
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| author | Ei Shiomi Renpei Kato Mitugu Kanehira Ryo Takata Jun Sugimura Yasuyuki Nakamura Takashi Ujiie Takaya Abe Wataru Obara |
| author_facet | Ei Shiomi Renpei Kato Mitugu Kanehira Ryo Takata Jun Sugimura Yasuyuki Nakamura Takashi Ujiie Takaya Abe Wataru Obara |
| author_sort | Ei Shiomi |
| collection | DOAJ |
| description | Abstract Objectives This study aims to investigate whether a cribriform pattern on prostate biopsy may be a factor in suspicion of intraductal carcinoma of the prostate after radical prostatectomy. Methods This retrospective study assessed 100 men who underwent prostatectomy from 2015 to 2019. Participants were grouped as 76 patients with Gleason pattern 4 and 24 patients without this pattern. All 100 participants underwent retrograde radical prostatectomy and limited lymph node dissection. The same pathologist evaluated all specimens. The cribriform pattern was evaluated with haematoxylin and eosin counterstaining, and intraductal carcinoma of the prostate was evaluated with immunohistochemical analysis of cytokeratin 34βE12. Results Patients with intraductal carcinoma of the prostate on immunohistochemical analysis showed a significant tendency to relapse in the postoperative period, and those with the cribriform pattern on biopsy had a significant recurrence rate. In univariate and multivariate analyses, intraductal carcinoma of the prostate confirmed in biopsy tissue was an independent predictor of biochemical recurrence after prostatectomy. The rate of intraductal carcinoma of the prostate confirmation was 28% of cases with a cribriform pattern in biopsy tissue, which was increased to 62% in prostatectomy tissues. Conclusion The cribriform pattern in the biopsy tissue may be a predictor for intraductal carcinoma of the prostate. |
| first_indexed | 2024-04-09T19:42:39Z |
| format | Article |
| id | doaj.art-ee98a5bfaef540c0a1b124dcf76f6ad1 |
| institution | Directory Open Access Journal |
| issn | 2688-4526 |
| language | English |
| last_indexed | 2024-04-09T19:42:39Z |
| publishDate | 2023-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | BJUI Compass |
| spelling | doaj.art-ee98a5bfaef540c0a1b124dcf76f6ad12023-04-04T05:34:43ZengWileyBJUI Compass2688-45262023-05-014333934510.1002/bco2.201Cribriform pattern in prostate tissues: Predictor for intraductal carcinoma of the prostate based on biopsy and radical prostatectomy pathologyEi Shiomi0Renpei Kato1Mitugu Kanehira2Ryo Takata3Jun Sugimura4Yasuyuki Nakamura5Takashi Ujiie6Takaya Abe7Wataru Obara8Iwate Prefectural Ofunato Hospital Ofunato JapanIwate Medical University Iwate JapanIwate Medical University Iwate JapanIwate Medical University Iwate JapanIwate Medical University Iwate JapanIwate Prefectural Ofunato Hospital Ofunato JapanIwate Prefectural Ofunato Hospital Ofunato JapanIwate Medical University Iwate JapanIwate Medical University Iwate JapanAbstract Objectives This study aims to investigate whether a cribriform pattern on prostate biopsy may be a factor in suspicion of intraductal carcinoma of the prostate after radical prostatectomy. Methods This retrospective study assessed 100 men who underwent prostatectomy from 2015 to 2019. Participants were grouped as 76 patients with Gleason pattern 4 and 24 patients without this pattern. All 100 participants underwent retrograde radical prostatectomy and limited lymph node dissection. The same pathologist evaluated all specimens. The cribriform pattern was evaluated with haematoxylin and eosin counterstaining, and intraductal carcinoma of the prostate was evaluated with immunohistochemical analysis of cytokeratin 34βE12. Results Patients with intraductal carcinoma of the prostate on immunohistochemical analysis showed a significant tendency to relapse in the postoperative period, and those with the cribriform pattern on biopsy had a significant recurrence rate. In univariate and multivariate analyses, intraductal carcinoma of the prostate confirmed in biopsy tissue was an independent predictor of biochemical recurrence after prostatectomy. The rate of intraductal carcinoma of the prostate confirmation was 28% of cases with a cribriform pattern in biopsy tissue, which was increased to 62% in prostatectomy tissues. Conclusion The cribriform pattern in the biopsy tissue may be a predictor for intraductal carcinoma of the prostate.https://doi.org/10.1002/bco2.201biochemical recurrencecribriform patternGleason 4intraductal carcinoma of prostatepredictor |
| spellingShingle | Ei Shiomi Renpei Kato Mitugu Kanehira Ryo Takata Jun Sugimura Yasuyuki Nakamura Takashi Ujiie Takaya Abe Wataru Obara Cribriform pattern in prostate tissues: Predictor for intraductal carcinoma of the prostate based on biopsy and radical prostatectomy pathology BJUI Compass biochemical recurrence cribriform pattern Gleason 4 intraductal carcinoma of prostate predictor |
| title | Cribriform pattern in prostate tissues: Predictor for intraductal carcinoma of the prostate based on biopsy and radical prostatectomy pathology |
| title_full | Cribriform pattern in prostate tissues: Predictor for intraductal carcinoma of the prostate based on biopsy and radical prostatectomy pathology |
| title_fullStr | Cribriform pattern in prostate tissues: Predictor for intraductal carcinoma of the prostate based on biopsy and radical prostatectomy pathology |
| title_full_unstemmed | Cribriform pattern in prostate tissues: Predictor for intraductal carcinoma of the prostate based on biopsy and radical prostatectomy pathology |
| title_short | Cribriform pattern in prostate tissues: Predictor for intraductal carcinoma of the prostate based on biopsy and radical prostatectomy pathology |
| title_sort | cribriform pattern in prostate tissues predictor for intraductal carcinoma of the prostate based on biopsy and radical prostatectomy pathology |
| topic | biochemical recurrence cribriform pattern Gleason 4 intraductal carcinoma of prostate predictor |
| url | https://doi.org/10.1002/bco2.201 |
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