Vasoprotective statin effectiveness in patients with carotid atherosclerosis
Vasoprotective effectiveness of atorvastatin and clopidogrel was investigated in 29 patients with duplex scanning-verified carotid atherosclerosis. Clinical and instrumental examination included assessment of lipid profile, endothelial function, intima-media thickness, carotid atherosclerotic plaque...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2007-10-01
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| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/2220 |
| Summary: | Vasoprotective effectiveness of atorvastatin and clopidogrel was investigated in 29 patients with duplex scanning-verified carotid atherosclerosis. Clinical and instrumental examination included assessment of lipid profile, endothelial function, intima-media thickness, carotid atherosclerotic plaque volume, serum levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL-6). The study lasted for 24 weeks. Atorvastatin and clopidogrel therapy was associated with improved endothelial vasodilatation, decreased intima-media thickness and atherosclerotic plaque volume, reduced levels of circulation pro-inflammatory cytokines (IL-6, TNF-alpha). Higher levels of the latter were linked to low echo-density atherosclerotic plaques. |
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| ISSN: | 1560-4071 2618-7620 |