Associations of Demographic Factors and Tobacco Use With Progesterone and Estradiol During Pregnancy
Objective To evaluate the association of biochemically validated prenatal tobacco use with serum progesterone and estradiol in the second trimester of pregnancy, controlling for demographic and personal factors. Study design This secondary analysis of a multicenter longitudinal study included 114 wo...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2018-11-01
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| Series: | SAGE Open Nursing |
| Online Access: | https://doi.org/10.1177/2377960818806285 |
| _version_ | 1828404052394770432 |
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| author | Kristin Ashford PhD Emily Rayens BS, BA Amanda T. Wiggins PhD Mary Kay Rayens PhD Molly Malany Sayre PhD John O’Brien MD |
| author_facet | Kristin Ashford PhD Emily Rayens BS, BA Amanda T. Wiggins PhD Mary Kay Rayens PhD Molly Malany Sayre PhD John O’Brien MD |
| author_sort | Kristin Ashford PhD |
| collection | DOAJ |
| description | Objective To evaluate the association of biochemically validated prenatal tobacco use with serum progesterone and estradiol in the second trimester of pregnancy, controlling for demographic and personal factors. Study design This secondary analysis of a multicenter longitudinal study included 114 women with singleton pregnancies. Multiple regression analysis assessed whether prenatal tobacco use was related to hormone levels during the second trimester, controlling for covariates (age, body mass index, and race or ethnicity, with gestational age added to subsequent models). Result In the initial regressions, tobacco users had significantly lower progesterone level compared with nonsmokers ( p = .037), while estradiol was unrelated to prenatal tobacco use. Women with greater body mass index also had significantly lower progesterone ( p = .028), but body mass index was unrelated to estradiol. With gestational age as an additional covariate, prenatal tobacco use was no longer a significant predictor of progesterone, but both body mass index and gestational age were significant ( F = 10.6, p < .001, R 2 = 0.35). For estradiol, the overall regression of estradiol on age, body mass index, and race or ethnicity was not significant ( F = 1.2, p = .31). With gestational age added to the model, the overall model was significant ( F = 7.2, p < .001, R 2 = 0.27). Conclusion This study provides additional evidence that prenatal tobacco use may influence lower serum progesterone during the second trimester. This is of particular concern given the link between depressed progesterone activity and risk for preterm birth. |
| first_indexed | 2024-12-10T10:29:35Z |
| format | Article |
| id | doaj.art-ee9e82265e234fa6bce737b49a84f5d4 |
| institution | Directory Open Access Journal |
| issn | 2377-9608 |
| language | English |
| last_indexed | 2024-12-10T10:29:35Z |
| publishDate | 2018-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Nursing |
| spelling | doaj.art-ee9e82265e234fa6bce737b49a84f5d42022-12-22T01:52:37ZengSAGE PublishingSAGE Open Nursing2377-96082018-11-01410.1177/2377960818806285Associations of Demographic Factors and Tobacco Use With Progesterone and Estradiol During PregnancyKristin Ashford PhD0Emily Rayens BS, BA1Amanda T. Wiggins PhD2Mary Kay Rayens PhD3Molly Malany Sayre PhD4John O’Brien MD5University of Kentucky Perinatal Research and Wellness Center, College of Nursing, Lexington, KY, USADepartment of Infectious Disease, University of Georgia, Athens, GA, USAUniversity of Kentucky Perinatal Research and Wellness Center, College of Nursing, Lexington, KY, USAUniversity of Kentucky College of Public Health, Lexington, KY, USAUniversity of Kentucky, Cincinnati, OH, USAMaternal Fetal Medicine Division, University of Kentucky College of Medicine, Lexington, KY, USAObjective To evaluate the association of biochemically validated prenatal tobacco use with serum progesterone and estradiol in the second trimester of pregnancy, controlling for demographic and personal factors. Study design This secondary analysis of a multicenter longitudinal study included 114 women with singleton pregnancies. Multiple regression analysis assessed whether prenatal tobacco use was related to hormone levels during the second trimester, controlling for covariates (age, body mass index, and race or ethnicity, with gestational age added to subsequent models). Result In the initial regressions, tobacco users had significantly lower progesterone level compared with nonsmokers ( p = .037), while estradiol was unrelated to prenatal tobacco use. Women with greater body mass index also had significantly lower progesterone ( p = .028), but body mass index was unrelated to estradiol. With gestational age as an additional covariate, prenatal tobacco use was no longer a significant predictor of progesterone, but both body mass index and gestational age were significant ( F = 10.6, p < .001, R 2 = 0.35). For estradiol, the overall regression of estradiol on age, body mass index, and race or ethnicity was not significant ( F = 1.2, p = .31). With gestational age added to the model, the overall model was significant ( F = 7.2, p < .001, R 2 = 0.27). Conclusion This study provides additional evidence that prenatal tobacco use may influence lower serum progesterone during the second trimester. This is of particular concern given the link between depressed progesterone activity and risk for preterm birth.https://doi.org/10.1177/2377960818806285 |
| spellingShingle | Kristin Ashford PhD Emily Rayens BS, BA Amanda T. Wiggins PhD Mary Kay Rayens PhD Molly Malany Sayre PhD John O’Brien MD Associations of Demographic Factors and Tobacco Use With Progesterone and Estradiol During Pregnancy SAGE Open Nursing |
| title | Associations of Demographic Factors and Tobacco Use With Progesterone and Estradiol During Pregnancy |
| title_full | Associations of Demographic Factors and Tobacco Use With Progesterone and Estradiol During Pregnancy |
| title_fullStr | Associations of Demographic Factors and Tobacco Use With Progesterone and Estradiol During Pregnancy |
| title_full_unstemmed | Associations of Demographic Factors and Tobacco Use With Progesterone and Estradiol During Pregnancy |
| title_short | Associations of Demographic Factors and Tobacco Use With Progesterone and Estradiol During Pregnancy |
| title_sort | associations of demographic factors and tobacco use with progesterone and estradiol during pregnancy |
| url | https://doi.org/10.1177/2377960818806285 |
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