Gabra5 plays a sexually dimorphic role in POMC neuron activity and glucose balance

Gabra5 plays a sexually dimorphic role in POMC neuron activity and glucose balance

Pro-opiomelanocortin (POMC) neurons are important for the regulation of body weight and glucose balance. The inhibitory tone to POMC neurons is mediated primarily by the GABA receptors. However, the detailed mechanisms and functions of GABA receptors are not well understood. The α5 subunit of GABAA...

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Bibliographic Details
Main Authors: Zhou Pei, Yang He, Jonathan C. Bean, Yongjie Yang, Hailan Liu, Meng Yu, Kaifan Yu, Ilirjana Hyseni, Xing Cai, Hesong Liu, Na Qu, Longlong Tu, Kristine M. Conde, Mengjie Wang, Yongxiang Li, Na Yin, Nan Zhang, Junying Han, Camille HS. Potts, Nikolas A. Scarcelli, Zili Yan, Pingwen Xu, Qi Wu, Yanlin He, Yong Xu, Chunmei Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Endocrinology
Subjects:
glucose tolerance
sex differences
POMC neurons
GABAA receptor
GABAergic input
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.889122/full

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