microRNA-136-5p from bone marrow mesenchymal stem cell-derived exosomes facilitates fracture healing by targeting LRP4 to activate the Wnt/β-catenin pathway

microRNA-136-5p from bone marrow mesenchymal stem cell-derived exosomes facilitates fracture healing by targeting LRP4 to activate the Wnt/β-catenin pathway

Aims: Exosomes derived from bone marrow mesenchymal stem cells (BMSCs) have been reported to be a promising cellular therapeutic approach for various human diseases. The current study aimed to investigate the mechanism of BMSC-derived exosomes carrying microRNA (miR)-136-5p in fracture healing. Meth...

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Bibliographic Details
Main Authors: Haichi Yu, Jun Zhang, Xiaoning Liu, Yingzhi Li
Format: Article
Language:English
Published: The British Editorial Society of Bone & Joint Surgery 2021-12-01
Series:Bone & Joint Research
Subjects:
bone marrow mesenchymal stem cells
exosomes
mir-136-5p
Online Access:https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.1012.BJR-2020-0275.R2

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