Synthetic Antimicrobial Immunomodulatory Peptides: Ongoing Studies and Clinical Trials
The increasingly widespread antimicrobial resistance forces the search for new antimicrobial substances capable of fighting infection. Antimicrobial peptides (AMPs) and their synthetic analogs form an extensive group of compounds of great structural diversity and multifunctionality, different modes...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-08-01
|
| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/11/8/1062 |
| _version_ | 1797432602743799808 |
|---|---|
| author | Małgorzata Lesiuk Małgorzata Paduszyńska Katarzyna E. Greber |
| author_facet | Małgorzata Lesiuk Małgorzata Paduszyńska Katarzyna E. Greber |
| author_sort | Małgorzata Lesiuk |
| collection | DOAJ |
| description | The increasingly widespread antimicrobial resistance forces the search for new antimicrobial substances capable of fighting infection. Antimicrobial peptides (AMPs) and their synthetic analogs form an extensive group of compounds of great structural diversity and multifunctionality, different modes of antimicrobial action, and considerable market potential. Some AMPs, in addition to their proven antibacterial, antifungal, and antiviral activity, also demonstrate anti-inflammatory and immunomodulatory capabilities; these are called innate defense regulator (IDR) peptides. IDR peptides stimulate or inhibit the body’s immune system, e.g., by stimulating leukocyte migration to the site of infection, driving macrophage differentiation and activation, providing chemotactic action for neutrophils, degranulation and activation of mast cells, altering chemokine and cytokine production, and even induction of angiogenesis and wound healing. Such multifunctional immunomodulatory peptide molecules are currently being investigated and developed. Exploring and utilizing IDR peptides as an indirect weapon against infectious diseases could represent a completely new strategy to cope with the issue of antimicrobial resistance. |
| first_indexed | 2024-03-09T10:02:58Z |
| format | Article |
| id | doaj.art-eea1597a55dd4605a2cf5a02988c1206 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T10:02:58Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-eea1597a55dd4605a2cf5a02988c12062023-12-01T23:19:35ZengMDPI AGAntibiotics2079-63822022-08-01118106210.3390/antibiotics11081062Synthetic Antimicrobial Immunomodulatory Peptides: Ongoing Studies and Clinical TrialsMałgorzata Lesiuk0Małgorzata Paduszyńska1Katarzyna E. Greber2Polygen Sp. z o.o., Portowa 16L/130, 44-100 Gliwice, PolandDepartment of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Al. Gen. J. Hallera 107, 80-416 Gdansk, PolandDepartment of Physical Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Al. Gen. J. Hallera 107, 80-416 Gdansk, PolandThe increasingly widespread antimicrobial resistance forces the search for new antimicrobial substances capable of fighting infection. Antimicrobial peptides (AMPs) and their synthetic analogs form an extensive group of compounds of great structural diversity and multifunctionality, different modes of antimicrobial action, and considerable market potential. Some AMPs, in addition to their proven antibacterial, antifungal, and antiviral activity, also demonstrate anti-inflammatory and immunomodulatory capabilities; these are called innate defense regulator (IDR) peptides. IDR peptides stimulate or inhibit the body’s immune system, e.g., by stimulating leukocyte migration to the site of infection, driving macrophage differentiation and activation, providing chemotactic action for neutrophils, degranulation and activation of mast cells, altering chemokine and cytokine production, and even induction of angiogenesis and wound healing. Such multifunctional immunomodulatory peptide molecules are currently being investigated and developed. Exploring and utilizing IDR peptides as an indirect weapon against infectious diseases could represent a completely new strategy to cope with the issue of antimicrobial resistance.https://www.mdpi.com/2079-6382/11/8/1062antimicrobial peptidesimmunomodulatory peptidesantibiotic resistanceclinical trials |
| spellingShingle | Małgorzata Lesiuk Małgorzata Paduszyńska Katarzyna E. Greber Synthetic Antimicrobial Immunomodulatory Peptides: Ongoing Studies and Clinical Trials Antibiotics antimicrobial peptides immunomodulatory peptides antibiotic resistance clinical trials |
| title | Synthetic Antimicrobial Immunomodulatory Peptides: Ongoing Studies and Clinical Trials |
| title_full | Synthetic Antimicrobial Immunomodulatory Peptides: Ongoing Studies and Clinical Trials |
| title_fullStr | Synthetic Antimicrobial Immunomodulatory Peptides: Ongoing Studies and Clinical Trials |
| title_full_unstemmed | Synthetic Antimicrobial Immunomodulatory Peptides: Ongoing Studies and Clinical Trials |
| title_short | Synthetic Antimicrobial Immunomodulatory Peptides: Ongoing Studies and Clinical Trials |
| title_sort | synthetic antimicrobial immunomodulatory peptides ongoing studies and clinical trials |
| topic | antimicrobial peptides immunomodulatory peptides antibiotic resistance clinical trials |
| url | https://www.mdpi.com/2079-6382/11/8/1062 |
| work_keys_str_mv | AT małgorzatalesiuk syntheticantimicrobialimmunomodulatorypeptidesongoingstudiesandclinicaltrials AT małgorzatapaduszynska syntheticantimicrobialimmunomodulatorypeptidesongoingstudiesandclinicaltrials AT katarzynaegreber syntheticantimicrobialimmunomodulatorypeptidesongoingstudiesandclinicaltrials |