Glyphosate and AMPA in Human Urine of HBM4EU-Aligned Studies: Part B Adults
Within HBM4EU, human biomonitoring (HBM) studies measuring glyphosate (Gly) and aminomethylphosphonic acid (AMPA) in urine samples from the general adult population were aligned and quality-controlled/assured. Data from four studies (ESB Germany (2015–2020); Swiss HBM4EU study (2020); DIET-HBM Icela...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Toxics |
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| Online Access: | https://www.mdpi.com/2305-6304/10/10/552 |
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| author | Jurgen Buekers Sylvie Remy Jos Bessems Eva Govarts Loïc Rambaud Margaux Riou Thorhallur I Halldorsson Kristin Ólafsdóttir Nicole Probst-Hensch Priska Ammann Till Weber Marike Kolossa-Gehring Marta Esteban-López Argelia Castaño Helle Raun Andersen Greet Schoeters |
| author_facet | Jurgen Buekers Sylvie Remy Jos Bessems Eva Govarts Loïc Rambaud Margaux Riou Thorhallur I Halldorsson Kristin Ólafsdóttir Nicole Probst-Hensch Priska Ammann Till Weber Marike Kolossa-Gehring Marta Esteban-López Argelia Castaño Helle Raun Andersen Greet Schoeters |
| author_sort | Jurgen Buekers |
| collection | DOAJ |
| description | Within HBM4EU, human biomonitoring (HBM) studies measuring glyphosate (Gly) and aminomethylphosphonic acid (AMPA) in urine samples from the general adult population were aligned and quality-controlled/assured. Data from four studies (ESB Germany (2015–2020); Swiss HBM4EU study (2020); DIET-HBM Iceland (2019–2020); ESTEBAN France (2014–2016)) were included representing Northern and Western Europe. Overall, median values were below the reported quantification limits (LOQs) (0.05–0.1 µg/L). The 95th percentiles (P95) ranged between 0.24 and 0.37 µg/L urine for Gly and between 0.21 and 0.38 µg/L for AMPA. Lower values were observed in adults compared to children. Indications exist for autonomous sources of AMPA in the environment. As for children, reversed dosimetry calculations based on HBM data in adults did not lead to exceedances of the ADI (proposed acceptable daily intake of EFSA for Gly 0.1 mg/kg bw/day based on histopathological findings in the salivary gland of rats) indicating no human health risks in the studied populations at the moment. However, the controversy on carcinogenicity, potential endocrine effects and the absence of a group ADI for Gly and AMPA induce uncertainty to the risk assessment. Exposure determinant analysis showed few significant associations. More data on specific subgroups, such as those occupationally exposed or living close to agricultural fields or with certain consumption patterns (vegetarian, vegan, organic food, high cereal consumer), are needed to evaluate major exposure sources. |
| first_indexed | 2024-03-09T19:26:22Z |
| format | Article |
| id | doaj.art-eea3a64d002246a095c8aa2b50bd9d13 |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-09T19:26:22Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-eea3a64d002246a095c8aa2b50bd9d132023-11-24T02:56:55ZengMDPI AGToxics2305-63042022-09-01101055210.3390/toxics10100552Glyphosate and AMPA in Human Urine of HBM4EU-Aligned Studies: Part B AdultsJurgen Buekers0Sylvie Remy1Jos Bessems2Eva Govarts3Loïc Rambaud4Margaux Riou5Thorhallur I Halldorsson6Kristin Ólafsdóttir7Nicole Probst-Hensch8Priska Ammann9Till Weber10Marike Kolossa-Gehring11Marta Esteban-López12Argelia Castaño13Helle Raun Andersen14Greet Schoeters15Unit Health, VITO, Flemish Institute for Technological Research, 2400 Mol, BelgiumUnit Health, VITO, Flemish Institute for Technological Research, 2400 Mol, BelgiumUnit Health, VITO, Flemish Institute for Technological Research, 2400 Mol, BelgiumUnit Health, VITO, Flemish Institute for Technological Research, 2400 Mol, BelgiumDepartment of Environmental and Occupational Health, Santé Publique France, 94415 Saint-Maurice, FranceDepartment of Environmental and Occupational Health, Santé Publique France, 94415 Saint-Maurice, FranceFaculty of Food Science and Nutrition, University of Iceland, 102 Reykjavik, IcelandFaculty of Medicine, University of Iceland, 102 Reykjavik, IcelandSwiss Tropical and Public Health institute, 4123 Allschwil, SwitzerlandSwiss Tropical and Public Health institute, 4123 Allschwil, SwitzerlandGerman Environment Agency (UBA), 06844 Dessau-Roßlau, GermanyGerman Environment Agency (UBA), 06844 Dessau-Roßlau, GermanyInstituto de Salud Carlos III, National Centre for Environmental Health, 28220 Madrid, SpainInstituto de Salud Carlos III, National Centre for Environmental Health, 28220 Madrid, SpainDepartment of Public Health, University of Southern Denmark, 5000 Odense, DenmarkUnit Health, VITO, Flemish Institute for Technological Research, 2400 Mol, BelgiumWithin HBM4EU, human biomonitoring (HBM) studies measuring glyphosate (Gly) and aminomethylphosphonic acid (AMPA) in urine samples from the general adult population were aligned and quality-controlled/assured. Data from four studies (ESB Germany (2015–2020); Swiss HBM4EU study (2020); DIET-HBM Iceland (2019–2020); ESTEBAN France (2014–2016)) were included representing Northern and Western Europe. Overall, median values were below the reported quantification limits (LOQs) (0.05–0.1 µg/L). The 95th percentiles (P95) ranged between 0.24 and 0.37 µg/L urine for Gly and between 0.21 and 0.38 µg/L for AMPA. Lower values were observed in adults compared to children. Indications exist for autonomous sources of AMPA in the environment. As for children, reversed dosimetry calculations based on HBM data in adults did not lead to exceedances of the ADI (proposed acceptable daily intake of EFSA for Gly 0.1 mg/kg bw/day based on histopathological findings in the salivary gland of rats) indicating no human health risks in the studied populations at the moment. However, the controversy on carcinogenicity, potential endocrine effects and the absence of a group ADI for Gly and AMPA induce uncertainty to the risk assessment. Exposure determinant analysis showed few significant associations. More data on specific subgroups, such as those occupationally exposed or living close to agricultural fields or with certain consumption patterns (vegetarian, vegan, organic food, high cereal consumer), are needed to evaluate major exposure sources.https://www.mdpi.com/2305-6304/10/10/552HBM4EUglyphosateAMPAexposureHBMadults |
| spellingShingle | Jurgen Buekers Sylvie Remy Jos Bessems Eva Govarts Loïc Rambaud Margaux Riou Thorhallur I Halldorsson Kristin Ólafsdóttir Nicole Probst-Hensch Priska Ammann Till Weber Marike Kolossa-Gehring Marta Esteban-López Argelia Castaño Helle Raun Andersen Greet Schoeters Glyphosate and AMPA in Human Urine of HBM4EU-Aligned Studies: Part B Adults Toxics HBM4EU glyphosate AMPA exposure HBM adults |
| title | Glyphosate and AMPA in Human Urine of HBM4EU-Aligned Studies: Part B Adults |
| title_full | Glyphosate and AMPA in Human Urine of HBM4EU-Aligned Studies: Part B Adults |
| title_fullStr | Glyphosate and AMPA in Human Urine of HBM4EU-Aligned Studies: Part B Adults |
| title_full_unstemmed | Glyphosate and AMPA in Human Urine of HBM4EU-Aligned Studies: Part B Adults |
| title_short | Glyphosate and AMPA in Human Urine of HBM4EU-Aligned Studies: Part B Adults |
| title_sort | glyphosate and ampa in human urine of hbm4eu aligned studies part b adults |
| topic | HBM4EU glyphosate AMPA exposure HBM adults |
| url | https://www.mdpi.com/2305-6304/10/10/552 |
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