Targeted Protein Degradation by Chimeric Compounds using Hydrophobic E3 Ligands and Adamantane Moiety

Targeted Protein Degradation by Chimeric Compounds using Hydrophobic E3 Ligands and Adamantane Moiety

Targeted protein degradation using small chimeric molecules, such as proteolysis-targeting chimeras (PROTACs) and specific and nongenetic inhibitors of apoptosis protein [IAP]-dependent protein erasers (SNIPERs), is a promising technology in drug discovery. We recently developed a novel class of chi...

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Bibliographic Details
Main Authors: Takuji Shoda, Nobumichi Ohoka, Genichiro Tsuji, Takuma Fujisato, Hideshi Inoue, Yosuke Demizu, Mikihiko Naito, Masaaki Kurihara
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Pharmaceuticals
Subjects:
protein degradation
chimeric compound
hydrophobic tagging
adamantane
Online Access:https://www.mdpi.com/1424-8247/13/3/34

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