Economic Separations of Organic Acidic or Basic Enantiomeric Mixtures—A Protocol Suggestion
In this review, we aim to present new concepts for the revisited separation of enantiomers from racemic compounds and a protocol worth to be followed in designing the preparation of pure enantiomers. We have taken into account not only the influence of the properties (eutectic composition) and chara...
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| Format: | Article |
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MDPI AG
2023-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/1/846 |
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| author | Emese Pálovics János Madarász György Pokol Elemér Fogassy Dorottya Fruzsina Bánhegyi |
| author_facet | Emese Pálovics János Madarász György Pokol Elemér Fogassy Dorottya Fruzsina Bánhegyi |
| author_sort | Emese Pálovics |
| collection | DOAJ |
| description | In this review, we aim to present new concepts for the revisited separation of enantiomers from racemic compounds and a protocol worth to be followed in designing the preparation of pure enantiomers. We have taken into account not only the influence of the properties (eutectic composition) and characteristics of the reactants (racemic compound, resolving agent), but also the behavior of the resulting diastereomers and the different conditions (e.g., crystallization time, solvents used, solvate-forming compounds, achiral additives, etc.). The examples discussed are resolutions developed by our research team, through which we will try to illustrate the impact of all these considerations, presenting the methodological investigations interpreting recent discoveries and observations. Some special solid-state analytical and structural investigations assisting us in the elucidation and invention design of the resolution processes of some active pharmaceutical ingredients, such as Tetramisole, tofisopam, and Amlodipine, are also shown. |
| first_indexed | 2024-03-11T09:58:23Z |
| format | Article |
| id | doaj.art-eeab60de03fc48f6864294ac2707e2a2 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:58:23Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-eeab60de03fc48f6864294ac2707e2a22023-11-16T15:39:17ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-01-0124184610.3390/ijms24010846Economic Separations of Organic Acidic or Basic Enantiomeric Mixtures—A Protocol SuggestionEmese Pálovics0János Madarász1György Pokol2Elemér Fogassy3Dorottya Fruzsina Bánhegyi4Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111 Budapest, HungaryDepartment of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111 Budapest, HungaryDepartment of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111 Budapest, HungaryDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111 Budapest, HungaryDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111 Budapest, HungaryIn this review, we aim to present new concepts for the revisited separation of enantiomers from racemic compounds and a protocol worth to be followed in designing the preparation of pure enantiomers. We have taken into account not only the influence of the properties (eutectic composition) and characteristics of the reactants (racemic compound, resolving agent), but also the behavior of the resulting diastereomers and the different conditions (e.g., crystallization time, solvents used, solvate-forming compounds, achiral additives, etc.). The examples discussed are resolutions developed by our research team, through which we will try to illustrate the impact of all these considerations, presenting the methodological investigations interpreting recent discoveries and observations. Some special solid-state analytical and structural investigations assisting us in the elucidation and invention design of the resolution processes of some active pharmaceutical ingredients, such as Tetramisole, tofisopam, and Amlodipine, are also shown.https://www.mdpi.com/1422-0067/24/1/846designable resolutionthermal analysisstructural analysismelting binary phase diagramseutectic compositionbehavior of enantiomers |
| spellingShingle | Emese Pálovics János Madarász György Pokol Elemér Fogassy Dorottya Fruzsina Bánhegyi Economic Separations of Organic Acidic or Basic Enantiomeric Mixtures—A Protocol Suggestion International Journal of Molecular Sciences designable resolution thermal analysis structural analysis melting binary phase diagrams eutectic composition behavior of enantiomers |
| title | Economic Separations of Organic Acidic or Basic Enantiomeric Mixtures—A Protocol Suggestion |
| title_full | Economic Separations of Organic Acidic or Basic Enantiomeric Mixtures—A Protocol Suggestion |
| title_fullStr | Economic Separations of Organic Acidic or Basic Enantiomeric Mixtures—A Protocol Suggestion |
| title_full_unstemmed | Economic Separations of Organic Acidic or Basic Enantiomeric Mixtures—A Protocol Suggestion |
| title_short | Economic Separations of Organic Acidic or Basic Enantiomeric Mixtures—A Protocol Suggestion |
| title_sort | economic separations of organic acidic or basic enantiomeric mixtures a protocol suggestion |
| topic | designable resolution thermal analysis structural analysis melting binary phase diagrams eutectic composition behavior of enantiomers |
| url | https://www.mdpi.com/1422-0067/24/1/846 |
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