A Flavonoid on the Brain: Quercetin as a Potential Therapeutic Agent in Central Nervous System Disorders
Quercetin is one of the most common, naturally occurring flavonoids, structurally classified to the flavonol subfamily. This compound, found in many edible and medicinal plants either as a free or glycosidated form, has been scientifically exploited for many years, and one could hardly expect it cou...
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MDPI AG
2022-04-01
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| Series: | Life |
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| author | Dagmara Wróbel-Biedrawa Karolina Grabowska Agnieszka Galanty Danuta Sobolewska Irma Podolak |
| author_facet | Dagmara Wróbel-Biedrawa Karolina Grabowska Agnieszka Galanty Danuta Sobolewska Irma Podolak |
| author_sort | Dagmara Wróbel-Biedrawa |
| collection | DOAJ |
| description | Quercetin is one of the most common, naturally occurring flavonoids, structurally classified to the flavonol subfamily. This compound, found in many edible and medicinal plants either as a free or glycosidated form, has been scientifically exploited for many years, and one could hardly expect it could be a hero of some additional story. Commonly recognized as an anti-inflammatory agent, quercetin not only limits capillary vessel permeability by inhibiting hyaluronidase but also blocks cyclooxygenases and lipoxygenases. As a typical flavonoid, it is also known for its antioxidant effect, which was confirmed by many in vitro and in vivo studies. Throughout the years, numerous other activities were reported for quercetin, including antidiabetic, anti-proliferative, or anti-viral. Of note, recent data have revealed its potential role as a therapeutic agent for several central nervous system disorders. This review provides an overview of available experimental data on quercetin and its complexes with respect to central nervous system diseases, with a main focus on some aspects that were not discussed previously, such as anti-anxiolytic effects, anti-Huntington’s disease activity, or therapeutic potential in brain cancer. Moreover, quercetin’s protective role in some of these diseases is discussed, especially as an anti-neuroinflammatory agent. Bearing in mind the poor bioavailability of this compound, possible options that would enhance its delivery to the site of action are also presented. |
| first_indexed | 2024-03-09T04:29:18Z |
| format | Article |
| id | doaj.art-eeab63991a33449884f6a0acd9a8eb31 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T04:29:18Z |
| publishDate | 2022-04-01 |
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| series | Life |
| spelling | doaj.art-eeab63991a33449884f6a0acd9a8eb312023-12-03T13:37:29ZengMDPI AGLife2075-17292022-04-0112459110.3390/life12040591A Flavonoid on the Brain: Quercetin as a Potential Therapeutic Agent in Central Nervous System DisordersDagmara Wróbel-Biedrawa0Karolina Grabowska1Agnieszka Galanty2Danuta Sobolewska3Irma Podolak4Department of Pharmacognosy, Faculty of Pharmacy, Medical College, Jagiellonian University, Medyczna 9, 30-688 Krakow, PolandDepartment of Pharmacognosy, Faculty of Pharmacy, Medical College, Jagiellonian University, Medyczna 9, 30-688 Krakow, PolandDepartment of Pharmacognosy, Faculty of Pharmacy, Medical College, Jagiellonian University, Medyczna 9, 30-688 Krakow, PolandDepartment of Pharmacognosy, Faculty of Pharmacy, Medical College, Jagiellonian University, Medyczna 9, 30-688 Krakow, PolandDepartment of Pharmacognosy, Faculty of Pharmacy, Medical College, Jagiellonian University, Medyczna 9, 30-688 Krakow, PolandQuercetin is one of the most common, naturally occurring flavonoids, structurally classified to the flavonol subfamily. This compound, found in many edible and medicinal plants either as a free or glycosidated form, has been scientifically exploited for many years, and one could hardly expect it could be a hero of some additional story. Commonly recognized as an anti-inflammatory agent, quercetin not only limits capillary vessel permeability by inhibiting hyaluronidase but also blocks cyclooxygenases and lipoxygenases. As a typical flavonoid, it is also known for its antioxidant effect, which was confirmed by many in vitro and in vivo studies. Throughout the years, numerous other activities were reported for quercetin, including antidiabetic, anti-proliferative, or anti-viral. Of note, recent data have revealed its potential role as a therapeutic agent for several central nervous system disorders. This review provides an overview of available experimental data on quercetin and its complexes with respect to central nervous system diseases, with a main focus on some aspects that were not discussed previously, such as anti-anxiolytic effects, anti-Huntington’s disease activity, or therapeutic potential in brain cancer. Moreover, quercetin’s protective role in some of these diseases is discussed, especially as an anti-neuroinflammatory agent. Bearing in mind the poor bioavailability of this compound, possible options that would enhance its delivery to the site of action are also presented.https://www.mdpi.com/2075-1729/12/4/591quercetinCNScognitionneuroinflammationantioxidantneurodegeneration |
| spellingShingle | Dagmara Wróbel-Biedrawa Karolina Grabowska Agnieszka Galanty Danuta Sobolewska Irma Podolak A Flavonoid on the Brain: Quercetin as a Potential Therapeutic Agent in Central Nervous System Disorders Life quercetin CNS cognition neuroinflammation antioxidant neurodegeneration |
| title | A Flavonoid on the Brain: Quercetin as a Potential Therapeutic Agent in Central Nervous System Disorders |
| title_full | A Flavonoid on the Brain: Quercetin as a Potential Therapeutic Agent in Central Nervous System Disorders |
| title_fullStr | A Flavonoid on the Brain: Quercetin as a Potential Therapeutic Agent in Central Nervous System Disorders |
| title_full_unstemmed | A Flavonoid on the Brain: Quercetin as a Potential Therapeutic Agent in Central Nervous System Disorders |
| title_short | A Flavonoid on the Brain: Quercetin as a Potential Therapeutic Agent in Central Nervous System Disorders |
| title_sort | flavonoid on the brain quercetin as a potential therapeutic agent in central nervous system disorders |
| topic | quercetin CNS cognition neuroinflammation antioxidant neurodegeneration |
| url | https://www.mdpi.com/2075-1729/12/4/591 |
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