Reverse engineering of drug induced DNA damage response signalling pathway reveals dual outcomes of ATM kinase inhibition

Reverse engineering of drug induced DNA damage response signalling pathway reveals dual outcomes of ATM kinase inhibition

The DNA Damage Response (DDR) pathway represents a signalling mechanism that is activated in eukaryotic cells following DNA damage and comprises of proteins involved in DNA damage detection, DNA repair, cell cycle arrest and apoptosis. This pathway consists of an intricate network of signalling inte...

Full description

Bibliographic Details
Main Authors: Michael A. Idowu, Hilal S Khalil, James L. Bown, Nikolai Zhelev
Format: Article
Language:English
Published: Pensoft Publishers 2013-12-01
Series:BioDiscovery
Subjects:
reverse engineering
DNA damage response
ATM
Online Access:https://biodiscovery.pensoft.net/article/8954/download/pdf/

Similar Items

Similar Items