Efficacy of Nimodipine Combined with Latanoprost in Treating Open-Angle Glaucoma and Its Influence on Ocular Hemodynamics and Visual Field Defects
Hui-Ping Duan,1 Rong Liu2 1Department of Ophthalmology, Shanxi Province Fenyang Hospital, Fenyang, 032200, Shanxi Province, People’s Republic of China; 2Department of Ophthalmology, Shanxi Datong University, Datong, 037000, Shanxi Province, People’s Republic of ChinaCorrespondence: Hui-Ping Duan, De...
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Dove Medical Press
2022-03-01
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| Series: | Drug Design, Development and Therapy |
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| Online Access: | https://www.dovepress.com/efficacy-of-nimodipine-combined-with-latanoprost-in-treating-open-angl-peer-reviewed-fulltext-article-DDDT |
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| author | Duan HP Liu R |
| author_facet | Duan HP Liu R |
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| description | Hui-Ping Duan,1 Rong Liu2 1Department of Ophthalmology, Shanxi Province Fenyang Hospital, Fenyang, 032200, Shanxi Province, People’s Republic of China; 2Department of Ophthalmology, Shanxi Datong University, Datong, 037000, Shanxi Province, People’s Republic of ChinaCorrespondence: Hui-Ping Duan, Department of Ophthalmology, Shanxi Province Fenyang Hospital, Fenyang, 032200, Shanxi Province, People’s Republic of China, Tel +86-13037099450, Email duanhuiping2002@163.comBackground: Open-angle glaucoma is a common ophthalmic disease, which has a great impact on the vision of middle-aged and elderly people. Medication plays an important role in the treatment of glaucoma, so finding effective drug treatment is of great significance to improve the quality of life of glaucoma patients.Objective: To explore the curative effect of nimodipine combined with latanoprost in the treatment of open-angle glaucoma and its effect on ocular hemodynamics and visual field defects.Methods: This study retrospectively analyzed the clinical data of 87 patients with open-angle glaucoma who came to the Shanxi Province Fenyang Hospital and The First Affiliated Hospital of Shanxi Datong University for treatment from January 2019 to January 2021. According to different treatment plans, the patients were divided into two groups: an observation group (n = 46) treated with nimodipine combined with latanoprost, and a control group (n = 41) treated by latanoprost monotherapy. Treatment efficacy, hemodynamics, visual field defects, 24-hour peak intraocular pressure, binocular optic disc parameters, adverse reactions and quality of life were recorded and compared between two groups of patients.Results: The overall therapeutic effect of the observation group was significantly better than that in the control group. After treatment, ocular hemodynamics, visual field defects, 24-hour peak intraocular pressure, binocular optic disc parameters and life quality of both groups were obviously improved compared to those before treatment, with more significant improvements in the observation group. In addition, there was no significant difference in the incidence of adverse reactions between the two groups.Conclusion: Nimodipine combined with latanoprost eye drops is effective in the treatment of primary open-angle glaucoma, which could effectively improve the ocular hemodynamics and visual field defects of patients with fewer adverse reactions and higher safety. Therefore, it can be further promoted and used in clinical practice.Keywords: nimodipine, latanoprost, open-angle glaucoma, ocular hemodynamics, degree of visual field defects |
| first_indexed | 2024-12-13T20:22:10Z |
| format | Article |
| id | doaj.art-eead6c615ad241fab649ab9a0b4667f1 |
| institution | Directory Open Access Journal |
| issn | 1177-8881 |
| language | English |
| last_indexed | 2024-12-13T20:22:10Z |
| publishDate | 2022-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Drug Design, Development and Therapy |
| spelling | doaj.art-eead6c615ad241fab649ab9a0b4667f12022-12-21T23:32:41ZengDove Medical PressDrug Design, Development and Therapy1177-88812022-03-01Volume 1674975773839Efficacy of Nimodipine Combined with Latanoprost in Treating Open-Angle Glaucoma and Its Influence on Ocular Hemodynamics and Visual Field DefectsDuan HPLiu RHui-Ping Duan,1 Rong Liu2 1Department of Ophthalmology, Shanxi Province Fenyang Hospital, Fenyang, 032200, Shanxi Province, People’s Republic of China; 2Department of Ophthalmology, Shanxi Datong University, Datong, 037000, Shanxi Province, People’s Republic of ChinaCorrespondence: Hui-Ping Duan, Department of Ophthalmology, Shanxi Province Fenyang Hospital, Fenyang, 032200, Shanxi Province, People’s Republic of China, Tel +86-13037099450, Email duanhuiping2002@163.comBackground: Open-angle glaucoma is a common ophthalmic disease, which has a great impact on the vision of middle-aged and elderly people. Medication plays an important role in the treatment of glaucoma, so finding effective drug treatment is of great significance to improve the quality of life of glaucoma patients.Objective: To explore the curative effect of nimodipine combined with latanoprost in the treatment of open-angle glaucoma and its effect on ocular hemodynamics and visual field defects.Methods: This study retrospectively analyzed the clinical data of 87 patients with open-angle glaucoma who came to the Shanxi Province Fenyang Hospital and The First Affiliated Hospital of Shanxi Datong University for treatment from January 2019 to January 2021. According to different treatment plans, the patients were divided into two groups: an observation group (n = 46) treated with nimodipine combined with latanoprost, and a control group (n = 41) treated by latanoprost monotherapy. Treatment efficacy, hemodynamics, visual field defects, 24-hour peak intraocular pressure, binocular optic disc parameters, adverse reactions and quality of life were recorded and compared between two groups of patients.Results: The overall therapeutic effect of the observation group was significantly better than that in the control group. After treatment, ocular hemodynamics, visual field defects, 24-hour peak intraocular pressure, binocular optic disc parameters and life quality of both groups were obviously improved compared to those before treatment, with more significant improvements in the observation group. In addition, there was no significant difference in the incidence of adverse reactions between the two groups.Conclusion: Nimodipine combined with latanoprost eye drops is effective in the treatment of primary open-angle glaucoma, which could effectively improve the ocular hemodynamics and visual field defects of patients with fewer adverse reactions and higher safety. Therefore, it can be further promoted and used in clinical practice.Keywords: nimodipine, latanoprost, open-angle glaucoma, ocular hemodynamics, degree of visual field defectshttps://www.dovepress.com/efficacy-of-nimodipine-combined-with-latanoprost-in-treating-open-angl-peer-reviewed-fulltext-article-DDDTnimodipinelatanoprostopen-angle glaucomaocular hemodynamicsdegree of visual field defects |
| spellingShingle | Duan HP Liu R Efficacy of Nimodipine Combined with Latanoprost in Treating Open-Angle Glaucoma and Its Influence on Ocular Hemodynamics and Visual Field Defects Drug Design, Development and Therapy nimodipine latanoprost open-angle glaucoma ocular hemodynamics degree of visual field defects |
| title | Efficacy of Nimodipine Combined with Latanoprost in Treating Open-Angle Glaucoma and Its Influence on Ocular Hemodynamics and Visual Field Defects |
| title_full | Efficacy of Nimodipine Combined with Latanoprost in Treating Open-Angle Glaucoma and Its Influence on Ocular Hemodynamics and Visual Field Defects |
| title_fullStr | Efficacy of Nimodipine Combined with Latanoprost in Treating Open-Angle Glaucoma and Its Influence on Ocular Hemodynamics and Visual Field Defects |
| title_full_unstemmed | Efficacy of Nimodipine Combined with Latanoprost in Treating Open-Angle Glaucoma and Its Influence on Ocular Hemodynamics and Visual Field Defects |
| title_short | Efficacy of Nimodipine Combined with Latanoprost in Treating Open-Angle Glaucoma and Its Influence on Ocular Hemodynamics and Visual Field Defects |
| title_sort | efficacy of nimodipine combined with latanoprost in treating open angle glaucoma and its influence on ocular hemodynamics and visual field defects |
| topic | nimodipine latanoprost open-angle glaucoma ocular hemodynamics degree of visual field defects |
| url | https://www.dovepress.com/efficacy-of-nimodipine-combined-with-latanoprost-in-treating-open-angl-peer-reviewed-fulltext-article-DDDT |
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