Birthweight predicts glomerular filtration rate in adult-life: population based cross sectional study
Introduction Worldwide, there is a global progressive rise of chronic kidney disease. In parallel, children born after intra-uterine growth retardation are surviving to adult-life and beyond. This study describes the association of birthweight with and estimated glomerular filtration rate (eGFR). Me...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | Renal Failure |
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| Online Access: | http://dx.doi.org/10.1080/0886022X.2021.1915798 |
| _version_ | 1818954130799984640 |
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| author | Issa Al Salmi Suad Hannawi |
| author_facet | Issa Al Salmi Suad Hannawi |
| author_sort | Issa Al Salmi |
| collection | DOAJ |
| description | Introduction Worldwide, there is a global progressive rise of chronic kidney disease. In parallel, children born after intra-uterine growth retardation are surviving to adult-life and beyond. This study describes the association of birthweight with and estimated glomerular filtration rate (eGFR). Methods Australian Diabetes, Obesity and Lifestyle (AusDiab) study participants were asked to complete a birthweight questionnaire. The associations between birthweight and eGFR were determined. Results A total of 4502 reported information related to their birthweight, with the other responders did not provide a value. The birthweight of the participants ranged from 0.4 to 7.0 kg with a mean-(SD) of 3.37 (0.7) kg. The mean (95%CI) birthweight was lower for females, 3.28 (0.6) kg, when compared to males, 3.5 (0.7) kg. Eight percent had a birthweight less than 2.5 kg. The eGFR was strongly and positively associated with birthweight, with people in the lowest sex-specific birthweight-quintiles having the lowest mean eGFR. This relationship persisted with adjustment for confounding factors. The OR(CI) for eGFR <10th-percentile (<61.4 ml/min for females and <73.4 for males) for people in the lowest vs. the higher birthweight-quintile was 2.19 (95%CI 1.14–4.2) for females and 2.37 (1.1–5.3) for males, after adjustment for other factors. Conclusions Birthweight had a positive relationship with eGFR. Possible explanations include an association of birthweight with nephron-endowment. From a global health perspective but more in developing countries and in populations in epidemiologic transition, where substantially lower birthweights coexist with recently improved infant and adult survivals, the overall impact of this phenomenon on the population health profile could be more substantial. |
| first_indexed | 2024-12-20T10:17:17Z |
| format | Article |
| id | doaj.art-eeae7016ffdd4d2289c7c76c0eab474f |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-12-20T10:17:17Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-eeae7016ffdd4d2289c7c76c0eab474f2022-12-21T19:44:02ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492021-01-0143166467510.1080/0886022X.2021.19157981915798Birthweight predicts glomerular filtration rate in adult-life: population based cross sectional studyIssa Al Salmi0Suad Hannawi1The Medicine Department, The Royal HospitalThe Medicine Department, MOHAPIntroduction Worldwide, there is a global progressive rise of chronic kidney disease. In parallel, children born after intra-uterine growth retardation are surviving to adult-life and beyond. This study describes the association of birthweight with and estimated glomerular filtration rate (eGFR). Methods Australian Diabetes, Obesity and Lifestyle (AusDiab) study participants were asked to complete a birthweight questionnaire. The associations between birthweight and eGFR were determined. Results A total of 4502 reported information related to their birthweight, with the other responders did not provide a value. The birthweight of the participants ranged from 0.4 to 7.0 kg with a mean-(SD) of 3.37 (0.7) kg. The mean (95%CI) birthweight was lower for females, 3.28 (0.6) kg, when compared to males, 3.5 (0.7) kg. Eight percent had a birthweight less than 2.5 kg. The eGFR was strongly and positively associated with birthweight, with people in the lowest sex-specific birthweight-quintiles having the lowest mean eGFR. This relationship persisted with adjustment for confounding factors. The OR(CI) for eGFR <10th-percentile (<61.4 ml/min for females and <73.4 for males) for people in the lowest vs. the higher birthweight-quintile was 2.19 (95%CI 1.14–4.2) for females and 2.37 (1.1–5.3) for males, after adjustment for other factors. Conclusions Birthweight had a positive relationship with eGFR. Possible explanations include an association of birthweight with nephron-endowment. From a global health perspective but more in developing countries and in populations in epidemiologic transition, where substantially lower birthweights coexist with recently improved infant and adult survivals, the overall impact of this phenomenon on the population health profile could be more substantial.http://dx.doi.org/10.1080/0886022X.2021.1915798birth weight (bw)low birth weight (lbw)intra-uterine growth retardation (iugr)non-communicable diseases (ncd)estimated glomerular filtration rate (egfr)albumin creatine ratio (acr) |
| spellingShingle | Issa Al Salmi Suad Hannawi Birthweight predicts glomerular filtration rate in adult-life: population based cross sectional study Renal Failure birth weight (bw) low birth weight (lbw) intra-uterine growth retardation (iugr) non-communicable diseases (ncd) estimated glomerular filtration rate (egfr) albumin creatine ratio (acr) |
| title | Birthweight predicts glomerular filtration rate in adult-life: population based cross sectional study |
| title_full | Birthweight predicts glomerular filtration rate in adult-life: population based cross sectional study |
| title_fullStr | Birthweight predicts glomerular filtration rate in adult-life: population based cross sectional study |
| title_full_unstemmed | Birthweight predicts glomerular filtration rate in adult-life: population based cross sectional study |
| title_short | Birthweight predicts glomerular filtration rate in adult-life: population based cross sectional study |
| title_sort | birthweight predicts glomerular filtration rate in adult life population based cross sectional study |
| topic | birth weight (bw) low birth weight (lbw) intra-uterine growth retardation (iugr) non-communicable diseases (ncd) estimated glomerular filtration rate (egfr) albumin creatine ratio (acr) |
| url | http://dx.doi.org/10.1080/0886022X.2021.1915798 |
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