Discriminating cross-reactivity in polyclonal IgG1 responses against SARS-CoV-2 variants of concern
Profiling antibody repertoires using proteomic approaches may provide a way of screening for antibody cross-reactivity against SARS-CoV-2 variants. Here the authors use a IgG1 specific cleavage method to analyse the IgG1 repertoire within recovered patients and relate this to antibody binding and ne...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-33899-1 |
| _version_ | 1798029882225065984 |
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| author | Danique M. H. van Rijswijck Albert Bondt Max Hoek Karlijn van der Straten Tom G. Caniels Meliawati Poniman Dirk Eggink Chantal Reusken Godelieve J. de Bree Rogier W. Sanders Marit J. van Gils Albert J. R. Heck |
| author_facet | Danique M. H. van Rijswijck Albert Bondt Max Hoek Karlijn van der Straten Tom G. Caniels Meliawati Poniman Dirk Eggink Chantal Reusken Godelieve J. de Bree Rogier W. Sanders Marit J. van Gils Albert J. R. Heck |
| author_sort | Danique M. H. van Rijswijck |
| collection | DOAJ |
| description | Profiling antibody repertoires using proteomic approaches may provide a way of screening for antibody cross-reactivity against SARS-CoV-2 variants. Here the authors use a IgG1 specific cleavage method to analyse the IgG1 repertoire within recovered patients and relate this to antibody binding and neutralisation. |
| first_indexed | 2024-04-11T19:32:23Z |
| format | Article |
| id | doaj.art-eeaed92f1ab84dfd938e3ee685a8d51e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T19:32:23Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-eeaed92f1ab84dfd938e3ee685a8d51e2022-12-22T04:06:58ZengNature PortfolioNature Communications2041-17232022-10-0113111010.1038/s41467-022-33899-1Discriminating cross-reactivity in polyclonal IgG1 responses against SARS-CoV-2 variants of concernDanique M. H. van Rijswijck0Albert Bondt1Max Hoek2Karlijn van der Straten3Tom G. Caniels4Meliawati Poniman5Dirk Eggink6Chantal Reusken7Godelieve J. de Bree8Rogier W. Sanders9Marit J. van Gils10Albert J. R. Heck11Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of UtrechtBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of UtrechtBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of UtrechtDepartment of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and ImmunityDepartment of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and ImmunityDepartment of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and ImmunityNational Institute for Public Health and the Environment, RIVMNational Institute for Public Health and the Environment, RIVMDepartment of Internal Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Institute for Infection and ImmunityDepartment of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and ImmunityDepartment of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and ImmunityBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of UtrechtProfiling antibody repertoires using proteomic approaches may provide a way of screening for antibody cross-reactivity against SARS-CoV-2 variants. Here the authors use a IgG1 specific cleavage method to analyse the IgG1 repertoire within recovered patients and relate this to antibody binding and neutralisation.https://doi.org/10.1038/s41467-022-33899-1 |
| spellingShingle | Danique M. H. van Rijswijck Albert Bondt Max Hoek Karlijn van der Straten Tom G. Caniels Meliawati Poniman Dirk Eggink Chantal Reusken Godelieve J. de Bree Rogier W. Sanders Marit J. van Gils Albert J. R. Heck Discriminating cross-reactivity in polyclonal IgG1 responses against SARS-CoV-2 variants of concern Nature Communications |
| title | Discriminating cross-reactivity in polyclonal IgG1 responses against SARS-CoV-2 variants of concern |
| title_full | Discriminating cross-reactivity in polyclonal IgG1 responses against SARS-CoV-2 variants of concern |
| title_fullStr | Discriminating cross-reactivity in polyclonal IgG1 responses against SARS-CoV-2 variants of concern |
| title_full_unstemmed | Discriminating cross-reactivity in polyclonal IgG1 responses against SARS-CoV-2 variants of concern |
| title_short | Discriminating cross-reactivity in polyclonal IgG1 responses against SARS-CoV-2 variants of concern |
| title_sort | discriminating cross reactivity in polyclonal igg1 responses against sars cov 2 variants of concern |
| url | https://doi.org/10.1038/s41467-022-33899-1 |
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