SIRT4 is an early regulator of branched-chain amino acid catabolism that promotes adipogenesis

SIRT4 is an early regulator of branched-chain amino acid catabolism that promotes adipogenesis

Summary: Upon nutrient stimulation, pre-adipocytes undergo differentiation to transform into mature adipocytes capable of storing nutrients as fat. We profiled cellular metabolite consumption to identify early metabolic drivers of adipocyte differentiation. We find that adipocyte differentiation rai...

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Bibliographic Details
Main Authors: Elma Zaganjor, Haejin Yoon, Jessica B. Spinelli, Elizabeth R. Nunn, Gaëlle Laurent, Paulina Keskinidis, Suganja Sivaloganathan, Shakchhi Joshi, Giulia Notarangelo, Stacy Mulei, Mathew T. Chvasta, Sarah A. Tucker, Krystle Kalafut, Robert A.H. van de Ven, Clary B. Clish, Marcia C. Haigis
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Cell Reports
Subjects:
adipogenesis
differentiation
SIRT4
sirtuin
amino acids
BCAA catabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472100721X

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