Risk of cardiovascular diseases in cancer patients: A nationwide representative cohort study in Taiwan
Abstract Background The associations with cancer and cardiovascular diseases (CVD) had inconsistent results. The study aimed to investigate the risk of cardiovascular diseases (CVD) between populations with and without cancer. Methods Patients with common cancers in Taiwan were enrolled in the study...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-022-10314-y |
| _version_ | 1811210807496671232 |
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| author | Tzu-Lin Yeh Min-Shu Hsu Hsin-Yin Hsu Ming-Chieh Tsai Jing-Rong Jhuang Chun-Ju Chiang Wen-Chung Lee Kuo-Liong Chien |
| author_facet | Tzu-Lin Yeh Min-Shu Hsu Hsin-Yin Hsu Ming-Chieh Tsai Jing-Rong Jhuang Chun-Ju Chiang Wen-Chung Lee Kuo-Liong Chien |
| author_sort | Tzu-Lin Yeh |
| collection | DOAJ |
| description | Abstract Background The associations with cancer and cardiovascular diseases (CVD) had inconsistent results. The study aimed to investigate the risk of cardiovascular diseases (CVD) between populations with and without cancer. Methods Patients with common cancers in Taiwan were enrolled in the study between 2007 and 2018 using the Taiwan Cancer Registry. We focused on colorectal cancer, women’s breast cancer, lung cancer, liver cancer, oral cancer, prostate cancer, and thyroid cancers. The study endpoint was fatal and non-fatal CVD, which was defined as ischemic heart disease and ischemic stroke according to the National Health Insurance Research Database. We compared the risk of CVD between patients with cancer and age- and sex-matched (1:1 ratio) participants who did not have cancer or CVD. Multivariable adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were obtained from Cox regression analysis. To evaluate the chronological trend, we estimated the HRs and 95% CI yearly since the diagnosis. Results Among the 552,485 cancer patients (mean age, 60.6 years; women, 47.7%) during the median follow-up period of 4.1 years, 32,634 cases of fatal and non-fatal CVD were identified. Compared with that noted in the non-cancer population, the overall fully adjusted HR with 95% CI was 1.28 (1.25, 1.30) in the cancer population. The CVD risk was the highest in the first year, the adjusted HR with 95% CI was 2.31 (2.23, 2.40), and this risk decreased yearly. Conclusions Patients with cancer had a significantly higher risk of fatal or non-fatal CVD. The risk was the highest in the first year since diagnosis and decreased yearly. |
| first_indexed | 2024-04-12T05:01:55Z |
| format | Article |
| id | doaj.art-eeb006e917bc44ef9f44dd3d39264526 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-12T05:01:55Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-eeb006e917bc44ef9f44dd3d392645262022-12-22T03:46:58ZengBMCBMC Cancer1471-24072022-11-012211810.1186/s12885-022-10314-yRisk of cardiovascular diseases in cancer patients: A nationwide representative cohort study in TaiwanTzu-Lin Yeh0Min-Shu Hsu1Hsin-Yin Hsu2Ming-Chieh Tsai3Jing-Rong Jhuang4Chun-Ju Chiang5Wen-Chung Lee6Kuo-Liong Chien7Department of Family Medicine, Hsinchu MacKay Memorial HospitalDepartment of Medical Research, MacKay Memorial HospitalInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan UniversityInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan UniversityInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan UniversityInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan UniversityInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan UniversityInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan UniversityAbstract Background The associations with cancer and cardiovascular diseases (CVD) had inconsistent results. The study aimed to investigate the risk of cardiovascular diseases (CVD) between populations with and without cancer. Methods Patients with common cancers in Taiwan were enrolled in the study between 2007 and 2018 using the Taiwan Cancer Registry. We focused on colorectal cancer, women’s breast cancer, lung cancer, liver cancer, oral cancer, prostate cancer, and thyroid cancers. The study endpoint was fatal and non-fatal CVD, which was defined as ischemic heart disease and ischemic stroke according to the National Health Insurance Research Database. We compared the risk of CVD between patients with cancer and age- and sex-matched (1:1 ratio) participants who did not have cancer or CVD. Multivariable adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were obtained from Cox regression analysis. To evaluate the chronological trend, we estimated the HRs and 95% CI yearly since the diagnosis. Results Among the 552,485 cancer patients (mean age, 60.6 years; women, 47.7%) during the median follow-up period of 4.1 years, 32,634 cases of fatal and non-fatal CVD were identified. Compared with that noted in the non-cancer population, the overall fully adjusted HR with 95% CI was 1.28 (1.25, 1.30) in the cancer population. The CVD risk was the highest in the first year, the adjusted HR with 95% CI was 2.31 (2.23, 2.40), and this risk decreased yearly. Conclusions Patients with cancer had a significantly higher risk of fatal or non-fatal CVD. The risk was the highest in the first year since diagnosis and decreased yearly.https://doi.org/10.1186/s12885-022-10314-yCancer patientsCardiovascular diseaseCohort studyOnco-cardiologyCardio-oncology |
| spellingShingle | Tzu-Lin Yeh Min-Shu Hsu Hsin-Yin Hsu Ming-Chieh Tsai Jing-Rong Jhuang Chun-Ju Chiang Wen-Chung Lee Kuo-Liong Chien Risk of cardiovascular diseases in cancer patients: A nationwide representative cohort study in Taiwan BMC Cancer Cancer patients Cardiovascular disease Cohort study Onco-cardiology Cardio-oncology |
| title | Risk of cardiovascular diseases in cancer patients: A nationwide representative cohort study in Taiwan |
| title_full | Risk of cardiovascular diseases in cancer patients: A nationwide representative cohort study in Taiwan |
| title_fullStr | Risk of cardiovascular diseases in cancer patients: A nationwide representative cohort study in Taiwan |
| title_full_unstemmed | Risk of cardiovascular diseases in cancer patients: A nationwide representative cohort study in Taiwan |
| title_short | Risk of cardiovascular diseases in cancer patients: A nationwide representative cohort study in Taiwan |
| title_sort | risk of cardiovascular diseases in cancer patients a nationwide representative cohort study in taiwan |
| topic | Cancer patients Cardiovascular disease Cohort study Onco-cardiology Cardio-oncology |
| url | https://doi.org/10.1186/s12885-022-10314-y |
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