Positive association between high-density lipoprotein cholesterol and bone mineral density in U.S. adults: the NHANES 2011–2018
Abstract Background Serum lipids are highly inheritable and play a major role in bone health. However, the relationship between high-density lipoprotein cholesterol (HDL-C) and bone mineral density (BMD) remains uncertain. The goal of this study was to see if there was a link between HDL-C levels an...
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| Format: | Article |
| Language: | English |
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BMC
2022-02-01
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| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13018-022-02986-w |
| _version_ | 1818015773374808064 |
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| author | Ruijie Xie Xiongjie Huang Qianlong Liu Mingjiang Liu |
| author_facet | Ruijie Xie Xiongjie Huang Qianlong Liu Mingjiang Liu |
| author_sort | Ruijie Xie |
| collection | DOAJ |
| description | Abstract Background Serum lipids are highly inheritable and play a major role in bone health. However, the relationship between high-density lipoprotein cholesterol (HDL-C) and bone mineral density (BMD) remains uncertain. The goal of this study was to see if there was a link between HDL-C levels and BMD in persons aged 20–59. Methods Multivariate logistic regression models were used to determine the link between HDL-C and lumbar BMD using data from the National Health and Nutrition Examination Survey (NHANES) 2011–2018. Generalized additive models and fitted smoothing curves were also used. Results The analysis included a total of 10,635 adults. After controlling for various variables, we discovered that HDL-C was positively linked with lumbar BMD. The favorable connection of HDL-C with lumbar BMD was maintained in subgroup analyses stratified by sex and race in women, but not in men, and in blacks, but not in whites. The relationship between HDL-C and lumbar BMD in men and whites was a U-shaped curve with the same inflection point: 0.98 mmol/L. Conclusions In people aged 20 to 59, our research discovered a positive relationship among HDL-C and lumbar BMD. Among males and whites, this relationship followed a U-shaped curve (inflection point: 0.98 mmol/L). HDL-C measurement might be used as a responsive biomarker for detecting osteoporosis early and guiding therapy. |
| first_indexed | 2024-04-14T07:03:03Z |
| format | Article |
| id | doaj.art-eeb1013022f04d029d69827e0eeb52f3 |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-04-14T07:03:03Z |
| publishDate | 2022-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-eeb1013022f04d029d69827e0eeb52f32022-12-22T02:06:43ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2022-02-011711910.1186/s13018-022-02986-wPositive association between high-density lipoprotein cholesterol and bone mineral density in U.S. adults: the NHANES 2011–2018Ruijie Xie0Xiongjie Huang1Qianlong Liu2Mingjiang Liu3Department of Hand Surgery, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South ChinaDepartment of Hand Surgery, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South ChinaDepartment of Hand Surgery, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South ChinaDepartment of Hand Surgery, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South ChinaAbstract Background Serum lipids are highly inheritable and play a major role in bone health. However, the relationship between high-density lipoprotein cholesterol (HDL-C) and bone mineral density (BMD) remains uncertain. The goal of this study was to see if there was a link between HDL-C levels and BMD in persons aged 20–59. Methods Multivariate logistic regression models were used to determine the link between HDL-C and lumbar BMD using data from the National Health and Nutrition Examination Survey (NHANES) 2011–2018. Generalized additive models and fitted smoothing curves were also used. Results The analysis included a total of 10,635 adults. After controlling for various variables, we discovered that HDL-C was positively linked with lumbar BMD. The favorable connection of HDL-C with lumbar BMD was maintained in subgroup analyses stratified by sex and race in women, but not in men, and in blacks, but not in whites. The relationship between HDL-C and lumbar BMD in men and whites was a U-shaped curve with the same inflection point: 0.98 mmol/L. Conclusions In people aged 20 to 59, our research discovered a positive relationship among HDL-C and lumbar BMD. Among males and whites, this relationship followed a U-shaped curve (inflection point: 0.98 mmol/L). HDL-C measurement might be used as a responsive biomarker for detecting osteoporosis early and guiding therapy.https://doi.org/10.1186/s13018-022-02986-wHigh-density lipoprotein cholesterolBone mineral densityOsteoporosisOsteopenia |
| spellingShingle | Ruijie Xie Xiongjie Huang Qianlong Liu Mingjiang Liu Positive association between high-density lipoprotein cholesterol and bone mineral density in U.S. adults: the NHANES 2011–2018 Journal of Orthopaedic Surgery and Research High-density lipoprotein cholesterol Bone mineral density Osteoporosis Osteopenia |
| title | Positive association between high-density lipoprotein cholesterol and bone mineral density in U.S. adults: the NHANES 2011–2018 |
| title_full | Positive association between high-density lipoprotein cholesterol and bone mineral density in U.S. adults: the NHANES 2011–2018 |
| title_fullStr | Positive association between high-density lipoprotein cholesterol and bone mineral density in U.S. adults: the NHANES 2011–2018 |
| title_full_unstemmed | Positive association between high-density lipoprotein cholesterol and bone mineral density in U.S. adults: the NHANES 2011–2018 |
| title_short | Positive association between high-density lipoprotein cholesterol and bone mineral density in U.S. adults: the NHANES 2011–2018 |
| title_sort | positive association between high density lipoprotein cholesterol and bone mineral density in u s adults the nhanes 2011 2018 |
| topic | High-density lipoprotein cholesterol Bone mineral density Osteoporosis Osteopenia |
| url | https://doi.org/10.1186/s13018-022-02986-w |
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