Efficacy of some metronidazole derivatives against Giardia lamblia, in vivo study
Giardiasis is a protozoal infection of small intestine caused by Giardia lamblia. This disease is usually asymptomatic, though it can present as acute or chronic diarrhea. Giardiasis, which is a major cause of intestinal infection, is endemic in Iran. Despite reports about drug resistance, long cour...
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2015-09-01
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| Series: | Trends in Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://tips.sums.ac.ir/index.php/TiPS/article/view/36/48 |
| _version_ | 1811211818415161344 |
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| author | Mohammad Hossein Motazedian Nilofar Mohammadpour Soghra Khabnadideh |
| author_facet | Mohammad Hossein Motazedian Nilofar Mohammadpour Soghra Khabnadideh |
| author_sort | Mohammad Hossein Motazedian |
| collection | DOAJ |
| description | Giardiasis is a protozoal infection of small intestine caused by Giardia lamblia. This disease is usually asymptomatic, though it can present as acute or chronic diarrhea. Giardiasis, which is a major cause of intestinal infection, is endemic in Iran. Despite reports about drug resistance, long course treatment and various side effects of metronidazole, it is the drug of choice for giardiasis. In this study, we investigated the in vivo effects of five new derivatives (a-e) of metronidazole (MTZ) on the Giardia lamblia trophozoite in infected mice. Giardia intestinalis cysts were isolated from a patient and purified by sucrose gradient method. Fifty purified cysts were fed to the mice. After development of infection, the new metronidazole derivatives were given to the mice and the results were compared with metronidazole as the positive control group. Compounds a and b showed desirable antigiardiasis activity and could destroy the cyst and trophozoite of Giardia lamblia in mice after both two and four days, but the activity of the other compounds appeared only after 4 days. |
| first_indexed | 2024-04-12T05:19:46Z |
| format | Article |
| id | doaj.art-eeb33b58df484b28a60d5ff14adf6676 |
| institution | Directory Open Access Journal |
| issn | 2423-5652 2423-5652 |
| language | English |
| last_indexed | 2024-04-12T05:19:46Z |
| publishDate | 2015-09-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Trends in Pharmaceutical Sciences |
| spelling | doaj.art-eeb33b58df484b28a60d5ff14adf66762022-12-22T03:46:33ZengShiraz University of Medical SciencesTrends in Pharmaceutical Sciences2423-56522423-56522015-09-0113149152Efficacy of some metronidazole derivatives against Giardia lamblia, in vivo studyMohammad Hossein Motazedian0Nilofar Mohammadpour1Soghra Khabnadideh2Basic Research in Infectious Diseases Center, Shiraz University of Medical Sciences, Shiraz, Iran.Department of Parasitology, School of Medicine. Ahvaz University of Medical Sciences, Ahvaz Iran.School of Pharmacy, and Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.Giardiasis is a protozoal infection of small intestine caused by Giardia lamblia. This disease is usually asymptomatic, though it can present as acute or chronic diarrhea. Giardiasis, which is a major cause of intestinal infection, is endemic in Iran. Despite reports about drug resistance, long course treatment and various side effects of metronidazole, it is the drug of choice for giardiasis. In this study, we investigated the in vivo effects of five new derivatives (a-e) of metronidazole (MTZ) on the Giardia lamblia trophozoite in infected mice. Giardia intestinalis cysts were isolated from a patient and purified by sucrose gradient method. Fifty purified cysts were fed to the mice. After development of infection, the new metronidazole derivatives were given to the mice and the results were compared with metronidazole as the positive control group. Compounds a and b showed desirable antigiardiasis activity and could destroy the cyst and trophozoite of Giardia lamblia in mice after both two and four days, but the activity of the other compounds appeared only after 4 days.http://tips.sums.ac.ir/index.php/TiPS/article/view/36/48GiardiasisMetronidazoleTreatment |
| spellingShingle | Mohammad Hossein Motazedian Nilofar Mohammadpour Soghra Khabnadideh Efficacy of some metronidazole derivatives against Giardia lamblia, in vivo study Trends in Pharmaceutical Sciences Giardiasis Metronidazole Treatment |
| title | Efficacy of some metronidazole derivatives against Giardia lamblia, in vivo study |
| title_full | Efficacy of some metronidazole derivatives against Giardia lamblia, in vivo study |
| title_fullStr | Efficacy of some metronidazole derivatives against Giardia lamblia, in vivo study |
| title_full_unstemmed | Efficacy of some metronidazole derivatives against Giardia lamblia, in vivo study |
| title_short | Efficacy of some metronidazole derivatives against Giardia lamblia, in vivo study |
| title_sort | efficacy of some metronidazole derivatives against giardia lamblia in vivo study |
| topic | Giardiasis Metronidazole Treatment |
| url | http://tips.sums.ac.ir/index.php/TiPS/article/view/36/48 |
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