Association of retroperitoneal fibrosis with malignancy and its outcomes
Abstract Introduction Retroperitoneal fibrosis (RPF) is characterized by a highly fibrotic retroperitoneal mass and encompasses the idiopathic form and secondary to malignancies. Because we have limited knowledge whether RPF is associated with malignancy, we aimed to investigate the relationship bet...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-09-01
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| Series: | Arthritis Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13075-021-02627-3 |
| _version_ | 1818731075517546496 |
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| author | Sang Jin Lee Jung Su Eun Min Jung Kim Yeong Wook Song Young Mo Kang |
| author_facet | Sang Jin Lee Jung Su Eun Min Jung Kim Yeong Wook Song Young Mo Kang |
| author_sort | Sang Jin Lee |
| collection | DOAJ |
| description | Abstract Introduction Retroperitoneal fibrosis (RPF) is characterized by a highly fibrotic retroperitoneal mass and encompasses the idiopathic form and secondary to malignancies. Because we have limited knowledge whether RPF is associated with malignancy, we aimed to investigate the relationship between RPF and malignancy and to compare the characteristics and prognosis of cancers among patients with RPF. Methods Medical records of 111 patients diagnosed as having RPF were reviewed and 38 cases of cancer, confirmed by biopsy, were identified. Standardized incidence ratios (SIRs) were calculated for cancers and stratified according to cancer type and RPF-cancer diagnosis interval. Cancer characteristics and outcomes were compared between RPF-cancer diagnosis intervals. Results The average age at RPF diagnosis was 59.2 ± 15.0 years, and 69.4% of the patients were male. The cancer SIRs in patients with RPF relative to age- and sex-matched individuals in the general population was 2.2 (1.6–3.1). SIRs of renal pelvis cancer and multiple myeloma were significantly higher than in the general population. When stratified by RPF-cancer intervals, the SIR for cancer was 9.9 within 1 year of RPF diagnosis, while no significant increase in the SIR was found after 1 year from RPF diagnosis. Cancer stage was more advanced at the time of diagnosis in patients within a 1-year interval for RPF than those with cancer within a >5-year interval, with a correspondingly increased mortality in the former patients. Conclusions RPF was significantly associated with malignancy, particularly those diagnosed within 1 year of RPF diagnosis. Cancer stages at diagnosis were more advanced and the mortality rate was higher in patients within a 1-year interval between RPF and cancer diagnosis than in those with a >5-year interval between diagnoses. |
| first_indexed | 2024-12-17T23:11:55Z |
| format | Article |
| id | doaj.art-eeb3e25318cc4d499007e2aeacbf5db2 |
| institution | Directory Open Access Journal |
| issn | 1478-6362 |
| language | English |
| last_indexed | 2024-12-17T23:11:55Z |
| publishDate | 2021-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Arthritis Research & Therapy |
| spelling | doaj.art-eeb3e25318cc4d499007e2aeacbf5db22022-12-21T21:29:07ZengBMCArthritis Research & Therapy1478-63622021-09-012311910.1186/s13075-021-02627-3Association of retroperitoneal fibrosis with malignancy and its outcomesSang Jin Lee0Jung Su Eun1Min Jung Kim2Yeong Wook Song3Young Mo Kang4Division of Rheumatology, School of Medicine, Kyungpook National UniversityDivision of Rheumatology, School of Medicine, Kyungpook National UniversityDivision of Rheumatology, College of Medicine, Seoul National UniversityDepartment of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Medical Research Institute, Seoul National UniversityDivision of Rheumatology, School of Medicine, Kyungpook National UniversityAbstract Introduction Retroperitoneal fibrosis (RPF) is characterized by a highly fibrotic retroperitoneal mass and encompasses the idiopathic form and secondary to malignancies. Because we have limited knowledge whether RPF is associated with malignancy, we aimed to investigate the relationship between RPF and malignancy and to compare the characteristics and prognosis of cancers among patients with RPF. Methods Medical records of 111 patients diagnosed as having RPF were reviewed and 38 cases of cancer, confirmed by biopsy, were identified. Standardized incidence ratios (SIRs) were calculated for cancers and stratified according to cancer type and RPF-cancer diagnosis interval. Cancer characteristics and outcomes were compared between RPF-cancer diagnosis intervals. Results The average age at RPF diagnosis was 59.2 ± 15.0 years, and 69.4% of the patients were male. The cancer SIRs in patients with RPF relative to age- and sex-matched individuals in the general population was 2.2 (1.6–3.1). SIRs of renal pelvis cancer and multiple myeloma were significantly higher than in the general population. When stratified by RPF-cancer intervals, the SIR for cancer was 9.9 within 1 year of RPF diagnosis, while no significant increase in the SIR was found after 1 year from RPF diagnosis. Cancer stage was more advanced at the time of diagnosis in patients within a 1-year interval for RPF than those with cancer within a >5-year interval, with a correspondingly increased mortality in the former patients. Conclusions RPF was significantly associated with malignancy, particularly those diagnosed within 1 year of RPF diagnosis. Cancer stages at diagnosis were more advanced and the mortality rate was higher in patients within a 1-year interval between RPF and cancer diagnosis than in those with a >5-year interval between diagnoses.https://doi.org/10.1186/s13075-021-02627-3Retroperitoneal fibrosisMalignancyStandardized incidence ratiosSurvival |
| spellingShingle | Sang Jin Lee Jung Su Eun Min Jung Kim Yeong Wook Song Young Mo Kang Association of retroperitoneal fibrosis with malignancy and its outcomes Arthritis Research & Therapy Retroperitoneal fibrosis Malignancy Standardized incidence ratios Survival |
| title | Association of retroperitoneal fibrosis with malignancy and its outcomes |
| title_full | Association of retroperitoneal fibrosis with malignancy and its outcomes |
| title_fullStr | Association of retroperitoneal fibrosis with malignancy and its outcomes |
| title_full_unstemmed | Association of retroperitoneal fibrosis with malignancy and its outcomes |
| title_short | Association of retroperitoneal fibrosis with malignancy and its outcomes |
| title_sort | association of retroperitoneal fibrosis with malignancy and its outcomes |
| topic | Retroperitoneal fibrosis Malignancy Standardized incidence ratios Survival |
| url | https://doi.org/10.1186/s13075-021-02627-3 |
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