Disruption of Membrane Integrity as a Molecular Initiating Event Determines the Toxicity of Polyhexamethylene Guanidine Phosphate Depending on the Routes of Exposure

Disruption of Membrane Integrity as a Molecular Initiating Event Determines the Toxicity of Polyhexamethylene Guanidine Phosphate Depending on the Routes of Exposure

Polyhexamethylene guanidine phosphate (PHMG-P), a cationic biocide, is widely used in household products due to its strong bactericidal activity and low toxicity. However, it causes fatal lung damage when inhaled. In this study, we investigated why PHMG-P causes fatal lung injury when inhaled, and d...

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Bibliographic Details
Main Authors: Jeongah Song, Kyung-Jin Jung, Mi-Jin Yang, Woojin Kim, Byoung-Seok Lee, Seong-Kyu Choe, Seong-Jin Kim, Jeong-Ho Hwang
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
polyhexamethylene guanidine phosphate
membrane integrity
route of exposure
lung injury
liver toxicity
Online Access:https://www.mdpi.com/1422-0067/23/6/3289

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