Improvement of Arterial Stiffness One Month after Bariatric Surgery and Potential Mechanisms
Arterial stiffness (AS) is an independent predictor of cardiovascular risk. We aimed to analyze changes (Δ) in AS 1-month post-bariatric surgery (BS) and search for possible pathophysiological mechanisms. Patients with severe obesity (43% hypertensives) were prospectively evaluated before and 1-mont...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/4/691 |
| _version_ | 1797411660748554240 |
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| author | Anna Oliveras Isabel Galceran Albert Goday Susana Vázquez Laia Sans Marta Riera David Benaiges Julio Pascual |
| author_facet | Anna Oliveras Isabel Galceran Albert Goday Susana Vázquez Laia Sans Marta Riera David Benaiges Julio Pascual |
| author_sort | Anna Oliveras |
| collection | DOAJ |
| description | Arterial stiffness (AS) is an independent predictor of cardiovascular risk. We aimed to analyze changes (Δ) in AS 1-month post-bariatric surgery (BS) and search for possible pathophysiological mechanisms. Patients with severe obesity (43% hypertensives) were prospectively evaluated before and 1-month post-BS, with AS assessed by pulse-wave velocity (PWV), augmentation index (AIx@75) and pulse pressure (PP). Ambulatory 24 h blood pressure (BP), anthropometric data, renin-angiotensin-aldosterone system (RAAS) components and several adipokines and inflammatory markers were also analyzed. Overall reduction in body weight was mean (interquartile range (IQR)) = 11.0% (9.6–13.1). A decrease in PWV, AIx@75 and PP was observed 1-month post-BS (all, <i>p</i> < 0.01). There were also significant Δ in BP, RAAS components, adipokines and inflammatory biomarkers. Multiple linear regression adjusted models showed that Δaldosterone was an independent variable (B coeff.95%CI) for final PWV (B = −0.003, −0.005 to 0.000; <i>p</i> = 0.022). Angiotensin-converting enzyme (ACE)/ACE2 and ACE were independent variables for final AIx@75 (B = 0.036, 0.005 to 0.066; <i>p</i> = 0.024) and PP (B = 0.010, 0.003 to 0.017; <i>p</i> = 0.01), respectively. There was no correlation between ΔAS and anthropometric changes nor with Δ of adipokines or inflammatory markers except high-sensitivity C-reactive protein (hs-CRP). Patients with PWV below median decreased PWV (mean, 95%CI = −0.18, −0.25 to −0.10; <i>p</i> < 0.001) and both AIx@75 and PP at 1-month, but not those with PWV above median. In conclusion, there is an improvement in AS 1-month post-BS that correlates with ΔBP and Δrenin-angiotensin-aldosterone components. The benefit is reduced in those with higher PWV. |
| first_indexed | 2024-03-09T04:48:23Z |
| format | Article |
| id | doaj.art-eeb639b324ee4dcc94cd951e69ffbe7c |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T04:48:23Z |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-eeb639b324ee4dcc94cd951e69ffbe7c2023-12-03T13:13:11ZengMDPI AGJournal of Clinical Medicine2077-03832021-02-0110469110.3390/jcm10040691Improvement of Arterial Stiffness One Month after Bariatric Surgery and Potential MechanismsAnna Oliveras0Isabel Galceran1Albert Goday2Susana Vázquez3Laia Sans4Marta Riera5David Benaiges6Julio Pascual7Nephrology Department, Hospital Universitari del Mar, 08003 Barcelona, SpainNephrology Department, Hospital Universitari del Mar, 08003 Barcelona, SpainIMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, SpainNephrology Department, Hospital Universitari del Mar, 08003 Barcelona, SpainNephrology Department, Hospital Universitari del Mar, 08003 Barcelona, SpainIMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, SpainIMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, SpainNephrology Department, Hospital Universitari del Mar, 08003 Barcelona, SpainArterial stiffness (AS) is an independent predictor of cardiovascular risk. We aimed to analyze changes (Δ) in AS 1-month post-bariatric surgery (BS) and search for possible pathophysiological mechanisms. Patients with severe obesity (43% hypertensives) were prospectively evaluated before and 1-month post-BS, with AS assessed by pulse-wave velocity (PWV), augmentation index (AIx@75) and pulse pressure (PP). Ambulatory 24 h blood pressure (BP), anthropometric data, renin-angiotensin-aldosterone system (RAAS) components and several adipokines and inflammatory markers were also analyzed. Overall reduction in body weight was mean (interquartile range (IQR)) = 11.0% (9.6–13.1). A decrease in PWV, AIx@75 and PP was observed 1-month post-BS (all, <i>p</i> < 0.01). There were also significant Δ in BP, RAAS components, adipokines and inflammatory biomarkers. Multiple linear regression adjusted models showed that Δaldosterone was an independent variable (B coeff.95%CI) for final PWV (B = −0.003, −0.005 to 0.000; <i>p</i> = 0.022). Angiotensin-converting enzyme (ACE)/ACE2 and ACE were independent variables for final AIx@75 (B = 0.036, 0.005 to 0.066; <i>p</i> = 0.024) and PP (B = 0.010, 0.003 to 0.017; <i>p</i> = 0.01), respectively. There was no correlation between ΔAS and anthropometric changes nor with Δ of adipokines or inflammatory markers except high-sensitivity C-reactive protein (hs-CRP). Patients with PWV below median decreased PWV (mean, 95%CI = −0.18, −0.25 to −0.10; <i>p</i> < 0.001) and both AIx@75 and PP at 1-month, but not those with PWV above median. In conclusion, there is an improvement in AS 1-month post-BS that correlates with ΔBP and Δrenin-angiotensin-aldosterone components. The benefit is reduced in those with higher PWV.https://www.mdpi.com/2077-0383/10/4/691bariatric surgeryarterial stiffnessrenin-angiotensin axis |
| spellingShingle | Anna Oliveras Isabel Galceran Albert Goday Susana Vázquez Laia Sans Marta Riera David Benaiges Julio Pascual Improvement of Arterial Stiffness One Month after Bariatric Surgery and Potential Mechanisms Journal of Clinical Medicine bariatric surgery arterial stiffness renin-angiotensin axis |
| title | Improvement of Arterial Stiffness One Month after Bariatric Surgery and Potential Mechanisms |
| title_full | Improvement of Arterial Stiffness One Month after Bariatric Surgery and Potential Mechanisms |
| title_fullStr | Improvement of Arterial Stiffness One Month after Bariatric Surgery and Potential Mechanisms |
| title_full_unstemmed | Improvement of Arterial Stiffness One Month after Bariatric Surgery and Potential Mechanisms |
| title_short | Improvement of Arterial Stiffness One Month after Bariatric Surgery and Potential Mechanisms |
| title_sort | improvement of arterial stiffness one month after bariatric surgery and potential mechanisms |
| topic | bariatric surgery arterial stiffness renin-angiotensin axis |
| url | https://www.mdpi.com/2077-0383/10/4/691 |
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