Serum insulin-like growth factor binding protein 3 as a promising diagnostic and prognostic biomarker in esophagogastric junction adenocarcinoma
Abstract Background Esophagogastric junction adenocarcinoma (EJA) lacks serum biomarkers to assist in diagnosis and prognosis. Here, we aimed to evaluate the diagnostic and prognostic value of serum insulin-like growth factor binding protein 3 (IGFBP3) in EJA patients. Methods 320 participants were...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer
2022-11-01
|
| Series: | Discover Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s12672-022-00591-1 |
| _version_ | 1811304454528434176 |
|---|---|
| author | Tian-Yan Ding Yu-Hui Peng Chao-Qun Hong Bin-Liang Huang Can-Tong Liu Yun Luo Ling-Yu Chu Biao Zhang Xin-Hao Li Qi-Qi Qu Yi-Wei Xu Fang-Cai Wu |
| author_facet | Tian-Yan Ding Yu-Hui Peng Chao-Qun Hong Bin-Liang Huang Can-Tong Liu Yun Luo Ling-Yu Chu Biao Zhang Xin-Hao Li Qi-Qi Qu Yi-Wei Xu Fang-Cai Wu |
| author_sort | Tian-Yan Ding |
| collection | DOAJ |
| description | Abstract Background Esophagogastric junction adenocarcinoma (EJA) lacks serum biomarkers to assist in diagnosis and prognosis. Here, we aimed to evaluate the diagnostic and prognostic value of serum insulin-like growth factor binding protein 3 (IGFBP3) in EJA patients. Methods 320 participants were recruited from November 2016 to January 2020, who were randomly divided into a training cohort (112 normal controls and 102 EJA patients including 24 early-stage patients) and a validation cohort (56 normal controls and 50 EJA patients including 12 early-stage patients). We used receiver operating characteristics curve (ROC) to evaluate diagnostic value. The predictive performance of the nomogram was evaluated by the concordance index (C-index). Results Serum IGFBP3 levels were significantly lower in early-stage EJA or EJA patients than those in controls (P < 0.01). Measurement of serum IGFBP3 demonstrated an area under curve of 0.819, specificity 90.18% and sensitivity 43.14% in training cohort. Similar results were observed in validation cohort (0.804, 87.50%, 42.00%). Importantly, serum IGFBP3 had a satisfactory diagnostic value for early-stage EJA (0.822, 90.18%, 45.83% and 0.811, 84.48%, 50.00% in training and validation cohorts, respectively). Furthermore, survival analysis demonstrated that lower serum IGFBP3 level was related to poor prognosis (P < 0.05). Cox multivariate analysis revealed that serum IGFBP3 was an independent prognostic factor (HR = 0.468, P = 0.005). Compared with TNM stage, a nomogram based on serum IGFBP3, tumor size and TNM stage indicated an improved C-index in prognostic prediction (0.625 vs. 0.735, P = 0.001). Conclusions We found that serum IGFBP3 was a potential diagnostic and prognostic marker of EJA. Meanwhile, the nomogram might predict the prognosis of EJA more accurately and efficiently. |
| first_indexed | 2024-04-13T08:07:30Z |
| format | Article |
| id | doaj.art-eeb766ede8f84189bba72b1ad22f5e49 |
| institution | Directory Open Access Journal |
| issn | 2730-6011 |
| language | English |
| last_indexed | 2024-04-13T08:07:30Z |
| publishDate | 2022-11-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj.art-eeb766ede8f84189bba72b1ad22f5e492022-12-22T02:55:07ZengSpringerDiscover Oncology2730-60112022-11-0113111410.1007/s12672-022-00591-1Serum insulin-like growth factor binding protein 3 as a promising diagnostic and prognostic biomarker in esophagogastric junction adenocarcinomaTian-Yan Ding0Yu-Hui Peng1Chao-Qun Hong2Bin-Liang Huang3Can-Tong Liu4Yun Luo5Ling-Yu Chu6Biao Zhang7Xin-Hao Li8Qi-Qi Qu9Yi-Wei Xu10Fang-Cai Wu11Department of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical CollegeDepartment of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical CollegeDepartment of Oncological Laboratory Research, The Cancer Hospital of Shantou University Medical CollegeDepartment of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical CollegeDepartment of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical CollegeDepartment of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical CollegeDepartment of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical CollegeDepartment of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical CollegeDepartment of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical CollegeDepartment of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical CollegeDepartment of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical CollegeEsophageal Cancer Prevention and Control Research Center, The Cancer Hospital of Shantou University Medical CollegeAbstract Background Esophagogastric junction adenocarcinoma (EJA) lacks serum biomarkers to assist in diagnosis and prognosis. Here, we aimed to evaluate the diagnostic and prognostic value of serum insulin-like growth factor binding protein 3 (IGFBP3) in EJA patients. Methods 320 participants were recruited from November 2016 to January 2020, who were randomly divided into a training cohort (112 normal controls and 102 EJA patients including 24 early-stage patients) and a validation cohort (56 normal controls and 50 EJA patients including 12 early-stage patients). We used receiver operating characteristics curve (ROC) to evaluate diagnostic value. The predictive performance of the nomogram was evaluated by the concordance index (C-index). Results Serum IGFBP3 levels were significantly lower in early-stage EJA or EJA patients than those in controls (P < 0.01). Measurement of serum IGFBP3 demonstrated an area under curve of 0.819, specificity 90.18% and sensitivity 43.14% in training cohort. Similar results were observed in validation cohort (0.804, 87.50%, 42.00%). Importantly, serum IGFBP3 had a satisfactory diagnostic value for early-stage EJA (0.822, 90.18%, 45.83% and 0.811, 84.48%, 50.00% in training and validation cohorts, respectively). Furthermore, survival analysis demonstrated that lower serum IGFBP3 level was related to poor prognosis (P < 0.05). Cox multivariate analysis revealed that serum IGFBP3 was an independent prognostic factor (HR = 0.468, P = 0.005). Compared with TNM stage, a nomogram based on serum IGFBP3, tumor size and TNM stage indicated an improved C-index in prognostic prediction (0.625 vs. 0.735, P = 0.001). Conclusions We found that serum IGFBP3 was a potential diagnostic and prognostic marker of EJA. Meanwhile, the nomogram might predict the prognosis of EJA more accurately and efficiently.https://doi.org/10.1007/s12672-022-00591-1IGFBP3NomogramDiagnosisPrognosisEsophagogastric junction adenocarcinoma |
| spellingShingle | Tian-Yan Ding Yu-Hui Peng Chao-Qun Hong Bin-Liang Huang Can-Tong Liu Yun Luo Ling-Yu Chu Biao Zhang Xin-Hao Li Qi-Qi Qu Yi-Wei Xu Fang-Cai Wu Serum insulin-like growth factor binding protein 3 as a promising diagnostic and prognostic biomarker in esophagogastric junction adenocarcinoma Discover Oncology IGFBP3 Nomogram Diagnosis Prognosis Esophagogastric junction adenocarcinoma |
| title | Serum insulin-like growth factor binding protein 3 as a promising diagnostic and prognostic biomarker in esophagogastric junction adenocarcinoma |
| title_full | Serum insulin-like growth factor binding protein 3 as a promising diagnostic and prognostic biomarker in esophagogastric junction adenocarcinoma |
| title_fullStr | Serum insulin-like growth factor binding protein 3 as a promising diagnostic and prognostic biomarker in esophagogastric junction adenocarcinoma |
| title_full_unstemmed | Serum insulin-like growth factor binding protein 3 as a promising diagnostic and prognostic biomarker in esophagogastric junction adenocarcinoma |
| title_short | Serum insulin-like growth factor binding protein 3 as a promising diagnostic and prognostic biomarker in esophagogastric junction adenocarcinoma |
| title_sort | serum insulin like growth factor binding protein 3 as a promising diagnostic and prognostic biomarker in esophagogastric junction adenocarcinoma |
| topic | IGFBP3 Nomogram Diagnosis Prognosis Esophagogastric junction adenocarcinoma |
| url | https://doi.org/10.1007/s12672-022-00591-1 |
| work_keys_str_mv | AT tianyanding seruminsulinlikegrowthfactorbindingprotein3asapromisingdiagnosticandprognosticbiomarkerinesophagogastricjunctionadenocarcinoma AT yuhuipeng seruminsulinlikegrowthfactorbindingprotein3asapromisingdiagnosticandprognosticbiomarkerinesophagogastricjunctionadenocarcinoma AT chaoqunhong seruminsulinlikegrowthfactorbindingprotein3asapromisingdiagnosticandprognosticbiomarkerinesophagogastricjunctionadenocarcinoma AT binlianghuang seruminsulinlikegrowthfactorbindingprotein3asapromisingdiagnosticandprognosticbiomarkerinesophagogastricjunctionadenocarcinoma AT cantongliu seruminsulinlikegrowthfactorbindingprotein3asapromisingdiagnosticandprognosticbiomarkerinesophagogastricjunctionadenocarcinoma AT yunluo seruminsulinlikegrowthfactorbindingprotein3asapromisingdiagnosticandprognosticbiomarkerinesophagogastricjunctionadenocarcinoma AT lingyuchu seruminsulinlikegrowthfactorbindingprotein3asapromisingdiagnosticandprognosticbiomarkerinesophagogastricjunctionadenocarcinoma AT biaozhang seruminsulinlikegrowthfactorbindingprotein3asapromisingdiagnosticandprognosticbiomarkerinesophagogastricjunctionadenocarcinoma AT xinhaoli seruminsulinlikegrowthfactorbindingprotein3asapromisingdiagnosticandprognosticbiomarkerinesophagogastricjunctionadenocarcinoma AT qiqiqu seruminsulinlikegrowthfactorbindingprotein3asapromisingdiagnosticandprognosticbiomarkerinesophagogastricjunctionadenocarcinoma AT yiweixu seruminsulinlikegrowthfactorbindingprotein3asapromisingdiagnosticandprognosticbiomarkerinesophagogastricjunctionadenocarcinoma AT fangcaiwu seruminsulinlikegrowthfactorbindingprotein3asapromisingdiagnosticandprognosticbiomarkerinesophagogastricjunctionadenocarcinoma |