Association between CYP3A4/CYP3A5 genetic polymorphisms and treatment outcomes of atorvastatin worldwide: is there enough research on the Egyptian population?

Association between CYP3A4/CYP3A5 genetic polymorphisms and treatment outcomes of atorvastatin worldwide: is there enough research on the Egyptian population?

Abstract Introduction Atorvastatin is regarded as the most frequently prescribed statin worldwide for dyslipidemia. However, clinical response and risk of adverse effects to statin therapy are associated with genetic variations. Numerous research linked statins pharmacokinetics (PK) variations to ge...

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Bibliographic Details
Main Authors: Mohammed G. Maslub, Mahasen A. Radwan, Nur Aizati Athirah Daud, Abubakar Sha’aban
Format: Article
Language:English
Published: BMC 2023-09-01
Series:European Journal of Medical Research
Subjects:
Cytochromes P450
CYP3A4
CYP3A5
Polymorphism
Atorvastatin
Adverse effect
Online Access:https://doi.org/10.1186/s40001-023-01038-1

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