Oxidative Stress at Birth Is Associated with the Concentration of Iron and Copper in Maternal Serum
Oxidative stress (OS) in the foetal and neonatal periods leads to many disorders in newborns and in later life. The nutritional status of pregnant women is considered to be one of the key factors that triggers OS. We investigated the relationship between the concentration of selected mineral element...
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MDPI AG
2021-04-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/5/1491 |
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| author | Karolina Rak Karolina Łoźna Marzena Styczyńska Łukasz Bobak Monika Bronkowska |
| author_facet | Karolina Rak Karolina Łoźna Marzena Styczyńska Łukasz Bobak Monika Bronkowska |
| author_sort | Karolina Rak |
| collection | DOAJ |
| description | Oxidative stress (OS) in the foetal and neonatal periods leads to many disorders in newborns and in later life. The nutritional status of pregnant women is considered to be one of the key factors that triggers OS. We investigated the relationship between the concentration of selected mineral elements in the blood of pregnant women and the concentration of 3′nitrotyrosine (3′NT) as a marker of OS in the umbilical cord blood of newborns. The study group consisted of 57 pregnant women and their newborn children. The concentrations of magnesium (Mg), calcium (Ca), iron (Fe), zinc (Zn) and copper (Cu) in maternal serum (MS) were measured by the flame atomic absorption/emission spectrometry (FAAS/FAES) method. The concentration of 3′NT in umbilical cord serum (UCS) of newborns was determined by the ELISA method. A positive correlation between MS Fe and UCS 3′NT in male newborns was shown (rho = 0.392, <i>p</i> = 0.053). Significantly higher UCS 3′NT was demonstrated in newborns, especially males, whose mothers were characterized by MS Fe higher than 400 μg/dL compared to those of mothers with MS Fe up to 300 μg/dL (<i>p</i> < 0.01). Moreover, a negative correlation between the MS Cu and UCS 3′NT in male newborns was observed (rho = −0.509, <i>p</i> = 0.008). Results of the study showed the need to develop strategies to optimize the nutritional status of pregnant women. Implementation of these strategies could contribute to reducing the risk of pre- and neonatal OS and its adverse health effects in the offspring. |
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| language | English |
| last_indexed | 2024-03-10T11:53:33Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-eeb8a4359c23412ba1dbd3937f19a1c52023-11-21T17:32:08ZengMDPI AGNutrients2072-66432021-04-01135149110.3390/nu13051491Oxidative Stress at Birth Is Associated with the Concentration of Iron and Copper in Maternal SerumKarolina Rak0Karolina Łoźna1Marzena Styczyńska2Łukasz Bobak3Monika Bronkowska4Department of Human Nutrition, Faculty of Biotechnology and Food Science, Wrocław University of Environmental and Life Sciences, 51-630 Wrocław, PolandDepartment of Human Nutrition, Faculty of Biotechnology and Food Science, Wrocław University of Environmental and Life Sciences, 51-630 Wrocław, PolandDepartment of Human Nutrition, Faculty of Biotechnology and Food Science, Wrocław University of Environmental and Life Sciences, 51-630 Wrocław, PolandDepartment of Functional Food Products Development, Faculty of Biotechnology and Food Science, Wrocław University of Environmental and Life Sciences, 51-630 Wrocław, PolandDepartment of Human Nutrition, Faculty of Biotechnology and Food Science, Wrocław University of Environmental and Life Sciences, 51-630 Wrocław, PolandOxidative stress (OS) in the foetal and neonatal periods leads to many disorders in newborns and in later life. The nutritional status of pregnant women is considered to be one of the key factors that triggers OS. We investigated the relationship between the concentration of selected mineral elements in the blood of pregnant women and the concentration of 3′nitrotyrosine (3′NT) as a marker of OS in the umbilical cord blood of newborns. The study group consisted of 57 pregnant women and their newborn children. The concentrations of magnesium (Mg), calcium (Ca), iron (Fe), zinc (Zn) and copper (Cu) in maternal serum (MS) were measured by the flame atomic absorption/emission spectrometry (FAAS/FAES) method. The concentration of 3′NT in umbilical cord serum (UCS) of newborns was determined by the ELISA method. A positive correlation between MS Fe and UCS 3′NT in male newborns was shown (rho = 0.392, <i>p</i> = 0.053). Significantly higher UCS 3′NT was demonstrated in newborns, especially males, whose mothers were characterized by MS Fe higher than 400 μg/dL compared to those of mothers with MS Fe up to 300 μg/dL (<i>p</i> < 0.01). Moreover, a negative correlation between the MS Cu and UCS 3′NT in male newborns was observed (rho = −0.509, <i>p</i> = 0.008). Results of the study showed the need to develop strategies to optimize the nutritional status of pregnant women. Implementation of these strategies could contribute to reducing the risk of pre- and neonatal OS and its adverse health effects in the offspring.https://www.mdpi.com/2072-6643/13/5/1491oxidative stress3′nitrotyrosinenutritional statusmineral elementspregnant women |
| spellingShingle | Karolina Rak Karolina Łoźna Marzena Styczyńska Łukasz Bobak Monika Bronkowska Oxidative Stress at Birth Is Associated with the Concentration of Iron and Copper in Maternal Serum Nutrients oxidative stress 3′nitrotyrosine nutritional status mineral elements pregnant women |
| title | Oxidative Stress at Birth Is Associated with the Concentration of Iron and Copper in Maternal Serum |
| title_full | Oxidative Stress at Birth Is Associated with the Concentration of Iron and Copper in Maternal Serum |
| title_fullStr | Oxidative Stress at Birth Is Associated with the Concentration of Iron and Copper in Maternal Serum |
| title_full_unstemmed | Oxidative Stress at Birth Is Associated with the Concentration of Iron and Copper in Maternal Serum |
| title_short | Oxidative Stress at Birth Is Associated with the Concentration of Iron and Copper in Maternal Serum |
| title_sort | oxidative stress at birth is associated with the concentration of iron and copper in maternal serum |
| topic | oxidative stress 3′nitrotyrosine nutritional status mineral elements pregnant women |
| url | https://www.mdpi.com/2072-6643/13/5/1491 |
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