Inhibiting BDNF Signaling Upregulates Hippocampal H3K9me3 in a Manner Dependent On In Vitro Aging and Oxidative Stress

Inhibiting BDNF Signaling Upregulates Hippocampal H3K9me3 in a Manner Dependent On In Vitro Aging and Oxidative Stress

Histone modifications are key contributors to the cognitive decline that occurs in aging and Alzheimer’s disease. Our lab has previously shown that elevated H3K9me3 in aged mice is correlated with synaptic loss, cognitive impairment and a reduction in brain derived neurotrophic factor (BDNF). Howeve...

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Bibliographic Details
Main Authors:	Andra Ionescu-Tucker, Liqi Tong, Nicole C. Berchtold, Carl W. Cotman
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-04-01
Series:	Frontiers in Aging
Subjects:	BDNF H3K9me3 epigenetics hippocampus oxidative stress
Online Access:	https://www.frontiersin.org/articles/10.3389/fragi.2022.796087/full

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