Pharmacological aspects of Co(II), Ni(II) and Cu(II) schiff base complexes: An insight
Schiff bases are versatile chemical compounds that are frequently utilized and manufactured by reacting various amines with carbonyl compounds (aldehydes/ketones), resulting in the formation of the azomethine/imine (–CN–) group by condensation reaction. Medical science is driven to generate novel d...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Results in Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715623000887 |
| _version_ | 1827920685303857152 |
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| author | Alka Seema Gautam Rajesh Kumar Prashant Singh Namita Gandhi Pallavi Jain |
| author_facet | Alka Seema Gautam Rajesh Kumar Prashant Singh Namita Gandhi Pallavi Jain |
| author_sort | Alka |
| collection | DOAJ |
| description | Schiff bases are versatile chemical compounds that are frequently utilized and manufactured by reacting various amines with carbonyl compounds (aldehydes/ketones), resulting in the formation of the azomethine/imine (–CN–) group by condensation reaction. Medical science is driven to generate novel drugs with revolutionary bioactivities and functionalities to cure diseases that are rapidly evolving. Schiff base (SB) is a dynamic pharmacophore that, through chelation, can create complexes with metals of various oxidation states. SB metal complexes have already been recognized as an effective branch of investigation in coordination science. In the recent years, scientists have paid close attention to SBs and the metal complexes owing to versatile potential in the pharmaceutics sector, such as antifungal, antibacterial, antiviral and antimalarial, anti-HIV, anti-cancer, anti-tuberculosis, and many others. These compounds have also been identified as potent oxidants, with applications in sensing and nanotechnology. The ligand environment, metal ion complexation, and lipophilic nature have an impact on the biological activity of transition metal complexes. SB metal complexes are the attractive targets for the development of broad-spectrum medicines due to their combination of pharmacological properties. The review focuses on the synthesis, spectroscopic characterization and in-vitro biomedical applications (antimicrobial, anticancer, antitumor, DNA binding and cleavage, antioxidant) of SBs as well as their Co(II), Ni(II) and Cu(II) transition metal complexes. |
| first_indexed | 2024-03-13T04:14:05Z |
| format | Article |
| id | doaj.art-eeb9c6d2543643d6996a81d5227d5c93 |
| institution | Directory Open Access Journal |
| issn | 2211-7156 |
| language | English |
| last_indexed | 2024-03-13T04:14:05Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj.art-eeb9c6d2543643d6996a81d5227d5c932023-06-21T06:52:16ZengElsevierResults in Chemistry2211-71562023-01-015100849Pharmacological aspects of Co(II), Ni(II) and Cu(II) schiff base complexes: An insight Alka0Seema Gautam1Rajesh Kumar2Prashant Singh3Namita Gandhi4Pallavi Jain5Department of Chemistry, SRM Institute of Science and Technology, Delhi-NCR Campus, Modinagar 201204, IndiaDepartment of Chemistry, Deshbandhu College, University of Delhi, New Delhi 110019, IndiaDepartment of Chemistry, R.D.S College, B.R.A Bihar University, Muzaffarpur 842002, IndiaDepartment of Chemistry, Atma Ram Sanatan Dharma College, University of Delhi, New Delhi, IndiaDepartment of Chemistry, Deshbandhu College, University of Delhi, New Delhi 110019, IndiaDepartment of Chemistry, SRM Institute of Science and Technology, Delhi-NCR Campus, Modinagar 201204, India; Corresponding author.Schiff bases are versatile chemical compounds that are frequently utilized and manufactured by reacting various amines with carbonyl compounds (aldehydes/ketones), resulting in the formation of the azomethine/imine (–CN–) group by condensation reaction. Medical science is driven to generate novel drugs with revolutionary bioactivities and functionalities to cure diseases that are rapidly evolving. Schiff base (SB) is a dynamic pharmacophore that, through chelation, can create complexes with metals of various oxidation states. SB metal complexes have already been recognized as an effective branch of investigation in coordination science. In the recent years, scientists have paid close attention to SBs and the metal complexes owing to versatile potential in the pharmaceutics sector, such as antifungal, antibacterial, antiviral and antimalarial, anti-HIV, anti-cancer, anti-tuberculosis, and many others. These compounds have also been identified as potent oxidants, with applications in sensing and nanotechnology. The ligand environment, metal ion complexation, and lipophilic nature have an impact on the biological activity of transition metal complexes. SB metal complexes are the attractive targets for the development of broad-spectrum medicines due to their combination of pharmacological properties. The review focuses on the synthesis, spectroscopic characterization and in-vitro biomedical applications (antimicrobial, anticancer, antitumor, DNA binding and cleavage, antioxidant) of SBs as well as their Co(II), Ni(II) and Cu(II) transition metal complexes.http://www.sciencedirect.com/science/article/pii/S2211715623000887Schiff basesMetal(II) complexesVersatileComplexationIn-vitro biomedical applications |
| spellingShingle | Alka Seema Gautam Rajesh Kumar Prashant Singh Namita Gandhi Pallavi Jain Pharmacological aspects of Co(II), Ni(II) and Cu(II) schiff base complexes: An insight Results in Chemistry Schiff bases Metal(II) complexes Versatile Complexation In-vitro biomedical applications |
| title | Pharmacological aspects of Co(II), Ni(II) and Cu(II) schiff base complexes: An insight |
| title_full | Pharmacological aspects of Co(II), Ni(II) and Cu(II) schiff base complexes: An insight |
| title_fullStr | Pharmacological aspects of Co(II), Ni(II) and Cu(II) schiff base complexes: An insight |
| title_full_unstemmed | Pharmacological aspects of Co(II), Ni(II) and Cu(II) schiff base complexes: An insight |
| title_short | Pharmacological aspects of Co(II), Ni(II) and Cu(II) schiff base complexes: An insight |
| title_sort | pharmacological aspects of co ii ni ii and cu ii schiff base complexes an insight |
| topic | Schiff bases Metal(II) complexes Versatile Complexation In-vitro biomedical applications |
| url | http://www.sciencedirect.com/science/article/pii/S2211715623000887 |
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