Regulation of Ascorbate-Glutathione Pathway in Mitigating Oxidative Damage in Plants under Abiotic Stress
Reactive oxygen species (ROS) generation is a usual phenomenon in a plant both under a normal and stressed condition. However, under unfavorable or adverse conditions, ROS production exceeds the capacity of the antioxidant defense system. Both non-enzymatic and enzymatic components of the antioxidan...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-09-01
|
| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/8/9/384 |
| _version_ | 1827841088257261568 |
|---|---|
| author | Mirza Hasanuzzaman M. H. M. Borhannuddin Bhuyan Taufika Islam Anee Khursheda Parvin Kamrun Nahar Jubayer Al Mahmud Masayuki Fujita |
| author_facet | Mirza Hasanuzzaman M. H. M. Borhannuddin Bhuyan Taufika Islam Anee Khursheda Parvin Kamrun Nahar Jubayer Al Mahmud Masayuki Fujita |
| author_sort | Mirza Hasanuzzaman |
| collection | DOAJ |
| description | Reactive oxygen species (ROS) generation is a usual phenomenon in a plant both under a normal and stressed condition. However, under unfavorable or adverse conditions, ROS production exceeds the capacity of the antioxidant defense system. Both non-enzymatic and enzymatic components of the antioxidant defense system either detoxify or scavenge ROS and mitigate their deleterious effects. The Ascorbate-Glutathione (AsA-GSH) pathway, also known as Asada–Halliwell pathway comprises of AsA, GSH, and four enzymes viz. ascorbate peroxidase, monodehydroascorbate reductase, dehydroascorbate reductase, and glutathione reductase, play a vital role in detoxifying ROS. Apart from ROS detoxification, they also interact with other defense systems in plants and protect the plants from various abiotic stress-induced damages. Several plant studies revealed that the upregulation or overexpression of AsA-GSH pathway enzymes and the enhancement of the AsA and GSH levels conferred plants better tolerance to abiotic stresses by reducing the ROS. In this review, we summarize the recent progress of the research on AsA-GSH pathway in terms of oxidative stress tolerance in plants. We also focus on the defense mechanisms as well as molecular interactions. |
| first_indexed | 2024-03-12T07:45:22Z |
| format | Article |
| id | doaj.art-eeba41952dae40c79a66eec946862799 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-12T07:45:22Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-eeba41952dae40c79a66eec9468627992023-09-02T21:02:33ZengMDPI AGAntioxidants2076-39212019-09-018938410.3390/antiox8090384antiox8090384Regulation of Ascorbate-Glutathione Pathway in Mitigating Oxidative Damage in Plants under Abiotic StressMirza Hasanuzzaman0M. H. M. Borhannuddin Bhuyan1Taufika Islam Anee2Khursheda Parvin3Kamrun Nahar4Jubayer Al Mahmud5Masayuki Fujita6Department of Agronomy, Faculty of Agriculture, Sher-e-Bangla Agricultural University, Dhaka 1207, BangladeshLaboratory of Plant Stress Responses, Department of Applied Biological Science, Faculty of Agriculture, Kagawa University, Miki-cho, Kita-gun, Kagawa 761-0795, JapanDepartment of Agronomy, Faculty of Agriculture, Sher-e-Bangla Agricultural University, Dhaka 1207, BangladeshLaboratory of Plant Stress Responses, Department of Applied Biological Science, Faculty of Agriculture, Kagawa University, Miki-cho, Kita-gun, Kagawa 761-0795, JapanDepartment of Agricultural Botany, Faculty of Agriculture, Sher-e-Bangla Agricultural University, Dhaka 1207, BangladeshDepartment of Agroforestry and Environmental Science, Faculty of Agriculture, Sher-e-Bangla Agricultural University, Dhaka 1207, BangladeshLaboratory of Plant Stress Responses, Department of Applied Biological Science, Faculty of Agriculture, Kagawa University, Miki-cho, Kita-gun, Kagawa 761-0795, JapanReactive oxygen species (ROS) generation is a usual phenomenon in a plant both under a normal and stressed condition. However, under unfavorable or adverse conditions, ROS production exceeds the capacity of the antioxidant defense system. Both non-enzymatic and enzymatic components of the antioxidant defense system either detoxify or scavenge ROS and mitigate their deleterious effects. The Ascorbate-Glutathione (AsA-GSH) pathway, also known as Asada–Halliwell pathway comprises of AsA, GSH, and four enzymes viz. ascorbate peroxidase, monodehydroascorbate reductase, dehydroascorbate reductase, and glutathione reductase, play a vital role in detoxifying ROS. Apart from ROS detoxification, they also interact with other defense systems in plants and protect the plants from various abiotic stress-induced damages. Several plant studies revealed that the upregulation or overexpression of AsA-GSH pathway enzymes and the enhancement of the AsA and GSH levels conferred plants better tolerance to abiotic stresses by reducing the ROS. In this review, we summarize the recent progress of the research on AsA-GSH pathway in terms of oxidative stress tolerance in plants. We also focus on the defense mechanisms as well as molecular interactions.https://www.mdpi.com/2076-3921/8/9/384antioxidant defensefree radicalsglyoxalase systemhydrogen peroxideplant abiotic stressreactive oxygen speciesredox biologystress signaling |
| spellingShingle | Mirza Hasanuzzaman M. H. M. Borhannuddin Bhuyan Taufika Islam Anee Khursheda Parvin Kamrun Nahar Jubayer Al Mahmud Masayuki Fujita Regulation of Ascorbate-Glutathione Pathway in Mitigating Oxidative Damage in Plants under Abiotic Stress Antioxidants antioxidant defense free radicals glyoxalase system hydrogen peroxide plant abiotic stress reactive oxygen species redox biology stress signaling |
| title | Regulation of Ascorbate-Glutathione Pathway in Mitigating Oxidative Damage in Plants under Abiotic Stress |
| title_full | Regulation of Ascorbate-Glutathione Pathway in Mitigating Oxidative Damage in Plants under Abiotic Stress |
| title_fullStr | Regulation of Ascorbate-Glutathione Pathway in Mitigating Oxidative Damage in Plants under Abiotic Stress |
| title_full_unstemmed | Regulation of Ascorbate-Glutathione Pathway in Mitigating Oxidative Damage in Plants under Abiotic Stress |
| title_short | Regulation of Ascorbate-Glutathione Pathway in Mitigating Oxidative Damage in Plants under Abiotic Stress |
| title_sort | regulation of ascorbate glutathione pathway in mitigating oxidative damage in plants under abiotic stress |
| topic | antioxidant defense free radicals glyoxalase system hydrogen peroxide plant abiotic stress reactive oxygen species redox biology stress signaling |
| url | https://www.mdpi.com/2076-3921/8/9/384 |
| work_keys_str_mv | AT mirzahasanuzzaman regulationofascorbateglutathionepathwayinmitigatingoxidativedamageinplantsunderabioticstress AT mhmborhannuddinbhuyan regulationofascorbateglutathionepathwayinmitigatingoxidativedamageinplantsunderabioticstress AT taufikaislamanee regulationofascorbateglutathionepathwayinmitigatingoxidativedamageinplantsunderabioticstress AT khurshedaparvin regulationofascorbateglutathionepathwayinmitigatingoxidativedamageinplantsunderabioticstress AT kamrunnahar regulationofascorbateglutathionepathwayinmitigatingoxidativedamageinplantsunderabioticstress AT jubayeralmahmud regulationofascorbateglutathionepathwayinmitigatingoxidativedamageinplantsunderabioticstress AT masayukifujita regulationofascorbateglutathionepathwayinmitigatingoxidativedamageinplantsunderabioticstress |