Peculiarities of toxicodynamics and hazard assessment of pymetrozine,a new insecticide
It is well known that despite an actual efficiency pesticides can have a negative impact on humans, animals and the environment. So, new pesticides must be regulated at the stage of their registration in order to prevent such a harmful effect of chemical crop protection agents (CCPA). In this contex...
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| Format: | Article |
| Language: | English |
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Dnipro State Medical University
2016-12-01
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| Series: | Medičnì Perspektivi |
| Subjects: | |
| Online Access: | http://medpers.dsma.dp.ua/issues/2016/N4/136-145.pdf |
| _version_ | 1819107208144617472 |
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| author | Korshun M.M. Ruda T.V. Blagaia А.V. Antonenko A.M. |
| author_facet | Korshun M.M. Ruda T.V. Blagaia А.V. Antonenko A.M. |
| author_sort | Korshun M.M. |
| collection | DOAJ |
| description | It is well known that despite an actual efficiency pesticides can have a negative impact on humans, animals and the environment. So, new pesticides must be regulated at the stage of their registration in order to prevent such a harmful effect of chemical crop protection agents (CCPA). In this context, the aim of our study was to assess the danger by using toxicological criteria and substantiate acceptable daily intake (ADI) of pymetrozine for humans. It was performed the expert-analytical study of the primary and secondary sources of information during study of its toxicity on laboratory animals. It was established that pymetrozine is related to 2 class of hazard (limiting indication is inhalation toxicity). In chronic study the lowest NOAEL on rats was set at 10 ppm (0,337 mg/kg) for systemic toxicity, which made it possible to substantiate ADI of pymetrozine for a human at 0,003 mg/kg. The definition of this criterion will allow to set a series of hygienic standards to be followed, without any harmful effect on a human. |
| first_indexed | 2024-12-22T02:50:23Z |
| format | Article |
| id | doaj.art-eeba53a2c67f49179d052f0a93ccec07 |
| institution | Directory Open Access Journal |
| issn | 2307-0404 2307-0404 |
| language | English |
| last_indexed | 2024-12-22T02:50:23Z |
| publishDate | 2016-12-01 |
| publisher | Dnipro State Medical University |
| record_format | Article |
| series | Medičnì Perspektivi |
| spelling | doaj.art-eeba53a2c67f49179d052f0a93ccec072022-12-21T18:41:24ZengDnipro State Medical UniversityMedičnì Perspektivi2307-04042307-04042016-12-01214136145Peculiarities of toxicodynamics and hazard assessment of pymetrozine,a new insecticideKorshun M.M.0Ruda T.V.1Blagaia А.V.2Antonenko A.M.3Bogomolets national medical university Institute of hygiene and ecologyBogomolets national medical university Institute of hygiene and ecologyBogomolets national medical university Institute of hygiene and ecologyBogomolets national medical university Institute of hygiene and ecologyIt is well known that despite an actual efficiency pesticides can have a negative impact on humans, animals and the environment. So, new pesticides must be regulated at the stage of their registration in order to prevent such a harmful effect of chemical crop protection agents (CCPA). In this context, the aim of our study was to assess the danger by using toxicological criteria and substantiate acceptable daily intake (ADI) of pymetrozine for humans. It was performed the expert-analytical study of the primary and secondary sources of information during study of its toxicity on laboratory animals. It was established that pymetrozine is related to 2 class of hazard (limiting indication is inhalation toxicity). In chronic study the lowest NOAEL on rats was set at 10 ppm (0,337 mg/kg) for systemic toxicity, which made it possible to substantiate ADI of pymetrozine for a human at 0,003 mg/kg. The definition of this criterion will allow to set a series of hygienic standards to be followed, without any harmful effect on a human.http://medpers.dsma.dp.ua/issues/2016/N4/136-145.pdfinsecticidespymetrozinetoxicityhazard assessmentacceptable daily intake |
| spellingShingle | Korshun M.M. Ruda T.V. Blagaia А.V. Antonenko A.M. Peculiarities of toxicodynamics and hazard assessment of pymetrozine,a new insecticide Medičnì Perspektivi insecticides pymetrozine toxicity hazard assessment acceptable daily intake |
| title | Peculiarities of toxicodynamics and hazard assessment of pymetrozine,a new insecticide |
| title_full | Peculiarities of toxicodynamics and hazard assessment of pymetrozine,a new insecticide |
| title_fullStr | Peculiarities of toxicodynamics and hazard assessment of pymetrozine,a new insecticide |
| title_full_unstemmed | Peculiarities of toxicodynamics and hazard assessment of pymetrozine,a new insecticide |
| title_short | Peculiarities of toxicodynamics and hazard assessment of pymetrozine,a new insecticide |
| title_sort | peculiarities of toxicodynamics and hazard assessment of pymetrozine a new insecticide |
| topic | insecticides pymetrozine toxicity hazard assessment acceptable daily intake |
| url | http://medpers.dsma.dp.ua/issues/2016/N4/136-145.pdf |
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