Oxidative Stress Parameters as Biomarkers of Cardiovascular Disease towards the Development and Progression
Cardiovascular disease (CVD) remains the leading cause of death globally, with unhealthy lifestyles today greatly increasing the risk. Over the decades, scientific investigation has been carried out on reactive oxygen species (ROS) and their resultant oxidative stress based on their changes made on...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/11/6/1175 |
| _version_ | 1797490507123785728 |
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| author | Amanda Shen-Yee Kong Kok Song Lai Cheng-Wan Hee Jiun Yan Loh Swee Hua Erin Lim Maran Sathiya |
| author_facet | Amanda Shen-Yee Kong Kok Song Lai Cheng-Wan Hee Jiun Yan Loh Swee Hua Erin Lim Maran Sathiya |
| author_sort | Amanda Shen-Yee Kong |
| collection | DOAJ |
| description | Cardiovascular disease (CVD) remains the leading cause of death globally, with unhealthy lifestyles today greatly increasing the risk. Over the decades, scientific investigation has been carried out on reactive oxygen species (ROS) and their resultant oxidative stress based on their changes made on biological targets such as lipids, proteins, and DNA. Since the existing clinical studies with antioxidants failed to provide relevant findings on CVD prediction, the focus has shifted towards recognition of oxidised targets as biomarkers to predict prognosis and response to accurate treatment. The identification of redox markers could help clinicians in providing risk stratification for CVD events beyond the traditional prognostic and diagnostic targets. This review will focus on how oxidant-related parameters can be applied as biomarkers for CVD based on recent clinical evidence. |
| first_indexed | 2024-03-10T00:33:57Z |
| format | Article |
| id | doaj.art-eebad680700546de9c6bf631243e9e69 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T00:33:57Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-eebad680700546de9c6bf631243e9e692023-11-23T15:20:54ZengMDPI AGAntioxidants2076-39212022-06-01116117510.3390/antiox11061175Oxidative Stress Parameters as Biomarkers of Cardiovascular Disease towards the Development and ProgressionAmanda Shen-Yee Kong0Kok Song Lai1Cheng-Wan Hee2Jiun Yan Loh3Swee Hua Erin Lim4Maran Sathiya5School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, Subang Jaya 47500, MalaysiaHealth Sciences Division, Abu Dhabi Women’s College, Higher Colleges of Technology, Abu Dhabi 41012, United Arab EmiratesFaculty of Health and Life Sciences, INTI International University, Persiaran Perdana BBN, Putra Nilai, Nilai 71800, MalaysiaCentre of Research for Advanced Aquaculture (CORAA), UCSI University, Cheras, Kuala Lumpur 56000, MalaysiaHealth Sciences Division, Abu Dhabi Women’s College, Higher Colleges of Technology, Abu Dhabi 41012, United Arab EmiratesSchool of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, Subang Jaya 47500, MalaysiaCardiovascular disease (CVD) remains the leading cause of death globally, with unhealthy lifestyles today greatly increasing the risk. Over the decades, scientific investigation has been carried out on reactive oxygen species (ROS) and their resultant oxidative stress based on their changes made on biological targets such as lipids, proteins, and DNA. Since the existing clinical studies with antioxidants failed to provide relevant findings on CVD prediction, the focus has shifted towards recognition of oxidised targets as biomarkers to predict prognosis and response to accurate treatment. The identification of redox markers could help clinicians in providing risk stratification for CVD events beyond the traditional prognostic and diagnostic targets. This review will focus on how oxidant-related parameters can be applied as biomarkers for CVD based on recent clinical evidence.https://www.mdpi.com/2076-3921/11/6/1175reactive oxygen speciesoxidative stressoxidantcardiovascularbiomarkers |
| spellingShingle | Amanda Shen-Yee Kong Kok Song Lai Cheng-Wan Hee Jiun Yan Loh Swee Hua Erin Lim Maran Sathiya Oxidative Stress Parameters as Biomarkers of Cardiovascular Disease towards the Development and Progression Antioxidants reactive oxygen species oxidative stress oxidant cardiovascular biomarkers |
| title | Oxidative Stress Parameters as Biomarkers of Cardiovascular Disease towards the Development and Progression |
| title_full | Oxidative Stress Parameters as Biomarkers of Cardiovascular Disease towards the Development and Progression |
| title_fullStr | Oxidative Stress Parameters as Biomarkers of Cardiovascular Disease towards the Development and Progression |
| title_full_unstemmed | Oxidative Stress Parameters as Biomarkers of Cardiovascular Disease towards the Development and Progression |
| title_short | Oxidative Stress Parameters as Biomarkers of Cardiovascular Disease towards the Development and Progression |
| title_sort | oxidative stress parameters as biomarkers of cardiovascular disease towards the development and progression |
| topic | reactive oxygen species oxidative stress oxidant cardiovascular biomarkers |
| url | https://www.mdpi.com/2076-3921/11/6/1175 |
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