Clinical epidemiology, risk factors and treatment outcomes of extended-spectrum beta-lactamase producing Enterobacteriaceae bacteremia among children in a Tertiary Care Hospital, Bangkok, Thailand
Abstract Objective Extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae infection is an emerging problem in paediatric populations leading to increased mortality. The purpose of this study was to determine the prevalence, risk factors and clinical outcomes of ESBL-producing Enterobac...
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| Format: | Article |
| Language: | English |
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BMC
2018-08-01
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| Series: | BMC Research Notes |
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| Online Access: | http://link.springer.com/article/10.1186/s13104-018-3729-3 |
| _version_ | 1817983815449051136 |
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| author | Thirapa Nivesvivat Phunlerd Piyaraj Sudaluck Thunyaharn Veerachai Watanaveeradej Detchvijitr Suwanpakdee |
| author_facet | Thirapa Nivesvivat Phunlerd Piyaraj Sudaluck Thunyaharn Veerachai Watanaveeradej Detchvijitr Suwanpakdee |
| author_sort | Thirapa Nivesvivat |
| collection | DOAJ |
| description | Abstract Objective Extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae infection is an emerging problem in paediatric populations leading to increased mortality. The purpose of this study was to determine the prevalence, risk factors and clinical outcomes of ESBL-producing Enterobacteriaceae in paediatric blood stream infections (BSIs). A retrospective review of paediatric patients diagnosed with Enterobacteriaceae bacteremia was performed at Phramongkutklao Hospital from 2010 to 2017. Results Among 97 non-duplicated blood isolates, the prevalence of ESBL-producing Enterobacteriaceae was 53.6% (28.9% Escherichia coli and 25.8% Klebsiella spp. isolates). The study indicated that the prevalence of ESBL infection was higher among patients with chronic illness, especially hematologic malignancies, than among patients without underlying disease (P = 0.01). No differences were observed in the prior use of any antibiotics, the use of extended-spectrum cephalosporin, neutropaenia or the presence of an indwelling central venous catheter. Mortality in the ESBL group was significantly higher than that in the non-ESBL group, with observed mortalities of 38.9% and 13.3%, respectively (P < 0.05). In conclusion, BSIs with ESBL-producing Enterobacteriaceae tended to increase infection rates and impact survival rates among paediatric patients. |
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| format | Article |
| id | doaj.art-eebc9af5cbdf4e85beb036ff38823dd3 |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-04-13T23:37:35Z |
| publishDate | 2018-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-eebc9af5cbdf4e85beb036ff38823dd32022-12-22T02:24:40ZengBMCBMC Research Notes1756-05002018-08-011111510.1186/s13104-018-3729-3Clinical epidemiology, risk factors and treatment outcomes of extended-spectrum beta-lactamase producing Enterobacteriaceae bacteremia among children in a Tertiary Care Hospital, Bangkok, ThailandThirapa Nivesvivat0Phunlerd Piyaraj1Sudaluck Thunyaharn2Veerachai Watanaveeradej3Detchvijitr Suwanpakdee4Department of Pediatrics, Phramongkutklao HospitalDepartment of Parasitology, Phramongkutklao College of MedicineFaculty of Medical Technology, Nakhon Ratchasima CollegeDepartment of Pediatrics, Phramongkutklao HospitalDepartment of Pediatrics, Phramongkutklao HospitalAbstract Objective Extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae infection is an emerging problem in paediatric populations leading to increased mortality. The purpose of this study was to determine the prevalence, risk factors and clinical outcomes of ESBL-producing Enterobacteriaceae in paediatric blood stream infections (BSIs). A retrospective review of paediatric patients diagnosed with Enterobacteriaceae bacteremia was performed at Phramongkutklao Hospital from 2010 to 2017. Results Among 97 non-duplicated blood isolates, the prevalence of ESBL-producing Enterobacteriaceae was 53.6% (28.9% Escherichia coli and 25.8% Klebsiella spp. isolates). The study indicated that the prevalence of ESBL infection was higher among patients with chronic illness, especially hematologic malignancies, than among patients without underlying disease (P = 0.01). No differences were observed in the prior use of any antibiotics, the use of extended-spectrum cephalosporin, neutropaenia or the presence of an indwelling central venous catheter. Mortality in the ESBL group was significantly higher than that in the non-ESBL group, with observed mortalities of 38.9% and 13.3%, respectively (P < 0.05). In conclusion, BSIs with ESBL-producing Enterobacteriaceae tended to increase infection rates and impact survival rates among paediatric patients.http://link.springer.com/article/10.1186/s13104-018-3729-3ESBL-producing EnterobacteriaceaeBacteremiaPaediatric |
| spellingShingle | Thirapa Nivesvivat Phunlerd Piyaraj Sudaluck Thunyaharn Veerachai Watanaveeradej Detchvijitr Suwanpakdee Clinical epidemiology, risk factors and treatment outcomes of extended-spectrum beta-lactamase producing Enterobacteriaceae bacteremia among children in a Tertiary Care Hospital, Bangkok, Thailand BMC Research Notes ESBL-producing Enterobacteriaceae Bacteremia Paediatric |
| title | Clinical epidemiology, risk factors and treatment outcomes of extended-spectrum beta-lactamase producing Enterobacteriaceae bacteremia among children in a Tertiary Care Hospital, Bangkok, Thailand |
| title_full | Clinical epidemiology, risk factors and treatment outcomes of extended-spectrum beta-lactamase producing Enterobacteriaceae bacteremia among children in a Tertiary Care Hospital, Bangkok, Thailand |
| title_fullStr | Clinical epidemiology, risk factors and treatment outcomes of extended-spectrum beta-lactamase producing Enterobacteriaceae bacteremia among children in a Tertiary Care Hospital, Bangkok, Thailand |
| title_full_unstemmed | Clinical epidemiology, risk factors and treatment outcomes of extended-spectrum beta-lactamase producing Enterobacteriaceae bacteremia among children in a Tertiary Care Hospital, Bangkok, Thailand |
| title_short | Clinical epidemiology, risk factors and treatment outcomes of extended-spectrum beta-lactamase producing Enterobacteriaceae bacteremia among children in a Tertiary Care Hospital, Bangkok, Thailand |
| title_sort | clinical epidemiology risk factors and treatment outcomes of extended spectrum beta lactamase producing enterobacteriaceae bacteremia among children in a tertiary care hospital bangkok thailand |
| topic | ESBL-producing Enterobacteriaceae Bacteremia Paediatric |
| url | http://link.springer.com/article/10.1186/s13104-018-3729-3 |
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