Demographic, clinical characteristics and cardiovascular disease burden in a Portuguese cohort of older chronic kidney disease patients
ABSTRACT Introduction: Chronic kidney disease (CKD) is an independent risk factor for several unfavorable outcomes including cardiovascular disease (CVD), particularly in the elderly, who represent the most rapidly growing segment of the end-stage kidney disease (ESKD) population. Portugal has the...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Nefrologia
2019-01-01
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| Series: | Brazilian Journal of Nephrology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002019005002103&lng=en&tlng=en |
| _version_ | 1819267143930216448 |
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| author | Josefina Maria Sousa Santos Lascasas Isabel Fonseca Jorge Malheiro Sofia Santos Andreia Campos Ana Castro Carla Moreira Sofia Correia Idalina Beirão Luísa Lobato António Cabrita |
| author_facet | Josefina Maria Sousa Santos Lascasas Isabel Fonseca Jorge Malheiro Sofia Santos Andreia Campos Ana Castro Carla Moreira Sofia Correia Idalina Beirão Luísa Lobato António Cabrita |
| author_sort | Josefina Maria Sousa Santos Lascasas |
| collection | DOAJ |
| description | ABSTRACT Introduction: Chronic kidney disease (CKD) is an independent risk factor for several unfavorable outcomes including cardiovascular disease (CVD), particularly in the elderly, who represent the most rapidly growing segment of the end-stage kidney disease (ESKD) population. Portugal has the highest European unadjusted incidence and prevalence rates of ESKD. In 2012, we started to follow a cohort of elderly CKD patients, we describe their baseline characteristics, risk profile, and cardiovascular disease burden. Methods: All CKD patients aged 65 years and older referred to our department during 2012 were enrolled. Baseline data included: demographic, CKD stage, medication, comorbid conditions. Estimated glomerular filtration rate (eGFR) was calculated by the CKD-EPI formula. Results: A total of 416 patients, 50% referred by primary care physicians, aged 77 ± 7 years, 52% male, with a median eGFR of 32 mL/min/1.73m2 participated in the study. Fifty percent had diabetes (DM), 85% dyslipidemia, 96% hypertension; 26% were current/former smokers, and 24% had a body mass index > 30 kg/m2. The prevalence of CVD was 62% and higher in stage 4-5 patients; in diabetics, it gradually increased with CKD progression (stage 3a < stage 3b < stage 4-5) (39, 58, 82%; p < 0.001). Conclusions: At baseline, our CKD elderly cohort had a higher burden of CVD. The prevalence of CVD was greater than in other European CKD cohorts. Lower level of eGFR was associated with a greater burden of CVD and was more pronounced in diabetics, highlighting the importance of strategically targeting cardiovascular risk reduction in these patients. |
| first_indexed | 2024-12-23T21:12:29Z |
| format | Article |
| id | doaj.art-eebdc5d3aece4f4fbb958c1eb479f0cf |
| institution | Directory Open Access Journal |
| issn | 2175-8239 |
| language | English |
| last_indexed | 2024-12-23T21:12:29Z |
| publishDate | 2019-01-01 |
| publisher | Sociedade Brasileira de Nefrologia |
| record_format | Article |
| series | Brazilian Journal of Nephrology |
| spelling | doaj.art-eebdc5d3aece4f4fbb958c1eb479f0cf2022-12-21T17:31:02ZengSociedade Brasileira de NefrologiaBrazilian Journal of Nephrology2175-82392019-01-01010.1590/2175-8239-jbn-2018-0120S0101-28002019005002103Demographic, clinical characteristics and cardiovascular disease burden in a Portuguese cohort of older chronic kidney disease patientsJosefina Maria Sousa Santos LascasasIsabel FonsecaJorge MalheiroSofia SantosAndreia CamposAna CastroCarla MoreiraSofia CorreiaIdalina BeirãoLuísa LobatoAntónio CabritaABSTRACT Introduction: Chronic kidney disease (CKD) is an independent risk factor for several unfavorable outcomes including cardiovascular disease (CVD), particularly in the elderly, who represent the most rapidly growing segment of the end-stage kidney disease (ESKD) population. Portugal has the highest European unadjusted incidence and prevalence rates of ESKD. In 2012, we started to follow a cohort of elderly CKD patients, we describe their baseline characteristics, risk profile, and cardiovascular disease burden. Methods: All CKD patients aged 65 years and older referred to our department during 2012 were enrolled. Baseline data included: demographic, CKD stage, medication, comorbid conditions. Estimated glomerular filtration rate (eGFR) was calculated by the CKD-EPI formula. Results: A total of 416 patients, 50% referred by primary care physicians, aged 77 ± 7 years, 52% male, with a median eGFR of 32 mL/min/1.73m2 participated in the study. Fifty percent had diabetes (DM), 85% dyslipidemia, 96% hypertension; 26% were current/former smokers, and 24% had a body mass index > 30 kg/m2. The prevalence of CVD was 62% and higher in stage 4-5 patients; in diabetics, it gradually increased with CKD progression (stage 3a < stage 3b < stage 4-5) (39, 58, 82%; p < 0.001). Conclusions: At baseline, our CKD elderly cohort had a higher burden of CVD. The prevalence of CVD was greater than in other European CKD cohorts. Lower level of eGFR was associated with a greater burden of CVD and was more pronounced in diabetics, highlighting the importance of strategically targeting cardiovascular risk reduction in these patients.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002019005002103&lng=en&tlng=enInsuficiência Renal CrônicaDoenças CardiovascularesIdoso |
| spellingShingle | Josefina Maria Sousa Santos Lascasas Isabel Fonseca Jorge Malheiro Sofia Santos Andreia Campos Ana Castro Carla Moreira Sofia Correia Idalina Beirão Luísa Lobato António Cabrita Demographic, clinical characteristics and cardiovascular disease burden in a Portuguese cohort of older chronic kidney disease patients Brazilian Journal of Nephrology Insuficiência Renal Crônica Doenças Cardiovasculares Idoso |
| title | Demographic, clinical characteristics and cardiovascular disease burden in a Portuguese cohort of older chronic kidney disease patients |
| title_full | Demographic, clinical characteristics and cardiovascular disease burden in a Portuguese cohort of older chronic kidney disease patients |
| title_fullStr | Demographic, clinical characteristics and cardiovascular disease burden in a Portuguese cohort of older chronic kidney disease patients |
| title_full_unstemmed | Demographic, clinical characteristics and cardiovascular disease burden in a Portuguese cohort of older chronic kidney disease patients |
| title_short | Demographic, clinical characteristics and cardiovascular disease burden in a Portuguese cohort of older chronic kidney disease patients |
| title_sort | demographic clinical characteristics and cardiovascular disease burden in a portuguese cohort of older chronic kidney disease patients |
| topic | Insuficiência Renal Crônica Doenças Cardiovasculares Idoso |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002019005002103&lng=en&tlng=en |
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