Predictive Model of Chemotherapy-Induced Myelosuppression for Patients with Esophageal Cancer
Background The influential factors of chemotherapy-induced myelosuppression in esophageal cancer in central China are unclear. This study aimed to develop a model for prediction of incidence of myelosuppression during chemotherapy among patients with esophageal cancer. Methods In this retrospective...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-09-01
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| Series: | Cancer Control |
| Online Access: | https://doi.org/10.1177/10732748221126929 |
| _version_ | 1811266072928583680 |
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| author | Ziming Zheng Qilin Zhang Yong Han Tingting Wu Yu Zhang |
| author_facet | Ziming Zheng Qilin Zhang Yong Han Tingting Wu Yu Zhang |
| author_sort | Ziming Zheng |
| collection | DOAJ |
| description | Background The influential factors of chemotherapy-induced myelosuppression in esophageal cancer in central China are unclear. This study aimed to develop a model for prediction of incidence of myelosuppression during chemotherapy among patients with esophageal cancer. Methods In this retrospective study, a total of 1446 patients with esophageal cancer who underwent five different chemotherapy regimens between 2013 and 2020 at our institute were randomly assigned in a 7:3 ratio to training and validation data sets. Clinical and drug-related variables were used to develop the prediction model from the training data set by the machine learning method of random forest. Finally, this model were tested in the validation data set. Results The prediction model were established with 16 indispensable variables selected from 46 variables. The model obtained an area under the receiver-operating characteristic curve of .883 and accompanied by prediction accuracy of 80.0%, sensitivity of 77.8% and specificity of 81.8%. Conclusion This new prediction model showed excellent predictive ability of incidence of myelosuppression in turn providing preventative measures for patients with esophageal cancer during chemotherapy. |
| first_indexed | 2024-04-12T20:35:29Z |
| format | Article |
| id | doaj.art-eebdebed98984c50abfcba091617022a |
| institution | Directory Open Access Journal |
| issn | 1073-2748 |
| language | English |
| last_indexed | 2024-04-12T20:35:29Z |
| publishDate | 2022-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cancer Control |
| spelling | doaj.art-eebdebed98984c50abfcba091617022a2022-12-22T03:17:36ZengSAGE PublishingCancer Control1073-27482022-09-012910.1177/10732748221126929Predictive Model of Chemotherapy-Induced Myelosuppression for Patients with Esophageal CancerZiming ZhengQilin ZhangYong HanTingting WuYu ZhangBackground The influential factors of chemotherapy-induced myelosuppression in esophageal cancer in central China are unclear. This study aimed to develop a model for prediction of incidence of myelosuppression during chemotherapy among patients with esophageal cancer. Methods In this retrospective study, a total of 1446 patients with esophageal cancer who underwent five different chemotherapy regimens between 2013 and 2020 at our institute were randomly assigned in a 7:3 ratio to training and validation data sets. Clinical and drug-related variables were used to develop the prediction model from the training data set by the machine learning method of random forest. Finally, this model were tested in the validation data set. Results The prediction model were established with 16 indispensable variables selected from 46 variables. The model obtained an area under the receiver-operating characteristic curve of .883 and accompanied by prediction accuracy of 80.0%, sensitivity of 77.8% and specificity of 81.8%. Conclusion This new prediction model showed excellent predictive ability of incidence of myelosuppression in turn providing preventative measures for patients with esophageal cancer during chemotherapy.https://doi.org/10.1177/10732748221126929 |
| spellingShingle | Ziming Zheng Qilin Zhang Yong Han Tingting Wu Yu Zhang Predictive Model of Chemotherapy-Induced Myelosuppression for Patients with Esophageal Cancer Cancer Control |
| title | Predictive Model of Chemotherapy-Induced Myelosuppression for Patients with Esophageal Cancer |
| title_full | Predictive Model of Chemotherapy-Induced Myelosuppression for Patients with Esophageal Cancer |
| title_fullStr | Predictive Model of Chemotherapy-Induced Myelosuppression for Patients with Esophageal Cancer |
| title_full_unstemmed | Predictive Model of Chemotherapy-Induced Myelosuppression for Patients with Esophageal Cancer |
| title_short | Predictive Model of Chemotherapy-Induced Myelosuppression for Patients with Esophageal Cancer |
| title_sort | predictive model of chemotherapy induced myelosuppression for patients with esophageal cancer |
| url | https://doi.org/10.1177/10732748221126929 |
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