Effects of Short-Wavelength Blue Light on Fibroblasts, Experimental Evidence in Wound Healing and Cutaneous Fibrosis
Fibroblasts play a crucial role in wound healing and skin fibrosis. It is also probably the cell model used to study in vitro photobiomodulation. Our previous in vivo results evidenced a faster recovery in blue-light-treated wounds (410–430 nm). In vitro experiments demonstrated that the lower dose...
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MDPI AG
2023-03-01
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| Series: | Medical Sciences Forum |
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| Online Access: | https://www.mdpi.com/2673-9992/21/1/27 |
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| author | Giada Magni Federica Cherchi Martina Banchelli Francesca Tatini Patrizia Nardini Daniele Guasti Elisabetta Coppi Anna Maria Pugliese Marco Fraccalvieri Stefano Bacci Francesca Rossi |
| author_facet | Giada Magni Federica Cherchi Martina Banchelli Francesca Tatini Patrizia Nardini Daniele Guasti Elisabetta Coppi Anna Maria Pugliese Marco Fraccalvieri Stefano Bacci Francesca Rossi |
| author_sort | Giada Magni |
| collection | DOAJ |
| description | Fibroblasts play a crucial role in wound healing and skin fibrosis. It is also probably the cell model used to study in vitro photobiomodulation. Our previous in vivo results evidenced a faster recovery in blue-light-treated wounds (410–430 nm). In vitro experiments demonstrated that the lower dose increases cell metabolism, while higher doses (30.9 and 41.2 J/cm<sup>2</sup>) reduce it. Furthermore, 20.6 J/cm<sup>2</sup> affects outward currents and Cytochrome C. Here, we described our preliminary results on the effects of blue LED light on mitochondria and reactive oxygen species production. Globally, our results demonstrated that short-wavelength blue LED light has PBM properties. |
| first_indexed | 2024-03-08T20:29:30Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2673-9992 |
| language | English |
| last_indexed | 2024-03-08T20:29:30Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medical Sciences Forum |
| spelling | doaj.art-eebf1f400be343d9b6611ae4a42119d32023-12-22T14:28:43ZengMDPI AGMedical Sciences Forum2673-99922023-03-012112710.3390/ECB2023-14268Effects of Short-Wavelength Blue Light on Fibroblasts, Experimental Evidence in Wound Healing and Cutaneous FibrosisGiada Magni0Federica Cherchi1Martina Banchelli2Francesca Tatini3Patrizia Nardini4Daniele Guasti5Elisabetta Coppi6Anna Maria Pugliese7Marco Fraccalvieri8Stefano Bacci9Francesca Rossi10Consiglio Nazionale delle Ricerche, Istituto di Fisica Applicata “Nello Carrara”, (CNR-IFAC), Sesto Fiorentino, 50019 Florence, ItalyDipartimento NEUROFARBA (Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino), Sezione di Farmacologia e Tossicologia, Università di Firenze, 50139 Florence, ItalyConsiglio Nazionale delle Ricerche, Istituto di Fisica Applicata “Nello Carrara”, (CNR-IFAC), Sesto Fiorentino, 50019 Florence, ItalyConsiglio Nazionale delle Ricerche, Istituto di Fisica Applicata “Nello Carrara”, (CNR-IFAC), Sesto Fiorentino, 50019 Florence, ItalyDipartimento di Scienze Biomediche, Sperimentali e Cliniche “Mario Serio”, Università di Firenze, 50139 Florence, ItalyDipartimento di Scienze Biomediche, Sperimentali e Cliniche “Mario Serio”, Università di Firenze, 50139 Florence, ItalyDipartimento NEUROFARBA (Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino), Sezione di Farmacologia e Tossicologia, Università di Firenze, 50139 Florence, ItalyDipartimento NEUROFARBA (Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino), Sezione di Farmacologia e Tossicologia, Università di Firenze, 50139 Florence, ItalySezione di Chirurgia Plastica e Ricostruttiva, Dipartimento di Chirurgia, Università di Torino, 10126 Turin, ItalyConsiglio Nazionale delle Ricerche, Istituto di Fisica Applicata “Nello Carrara”, (CNR-IFAC), Sesto Fiorentino, 50019 Florence, ItalyConsiglio Nazionale delle Ricerche, Istituto di Fisica Applicata “Nello Carrara”, (CNR-IFAC), Sesto Fiorentino, 50019 Florence, ItalyFibroblasts play a crucial role in wound healing and skin fibrosis. It is also probably the cell model used to study in vitro photobiomodulation. Our previous in vivo results evidenced a faster recovery in blue-light-treated wounds (410–430 nm). In vitro experiments demonstrated that the lower dose increases cell metabolism, while higher doses (30.9 and 41.2 J/cm<sup>2</sup>) reduce it. Furthermore, 20.6 J/cm<sup>2</sup> affects outward currents and Cytochrome C. Here, we described our preliminary results on the effects of blue LED light on mitochondria and reactive oxygen species production. Globally, our results demonstrated that short-wavelength blue LED light has PBM properties.https://www.mdpi.com/2673-9992/21/1/27photobiomodulationblue lightwound healingfibroblastsskin fibrosis |
| spellingShingle | Giada Magni Federica Cherchi Martina Banchelli Francesca Tatini Patrizia Nardini Daniele Guasti Elisabetta Coppi Anna Maria Pugliese Marco Fraccalvieri Stefano Bacci Francesca Rossi Effects of Short-Wavelength Blue Light on Fibroblasts, Experimental Evidence in Wound Healing and Cutaneous Fibrosis Medical Sciences Forum photobiomodulation blue light wound healing fibroblasts skin fibrosis |
| title | Effects of Short-Wavelength Blue Light on Fibroblasts, Experimental Evidence in Wound Healing and Cutaneous Fibrosis |
| title_full | Effects of Short-Wavelength Blue Light on Fibroblasts, Experimental Evidence in Wound Healing and Cutaneous Fibrosis |
| title_fullStr | Effects of Short-Wavelength Blue Light on Fibroblasts, Experimental Evidence in Wound Healing and Cutaneous Fibrosis |
| title_full_unstemmed | Effects of Short-Wavelength Blue Light on Fibroblasts, Experimental Evidence in Wound Healing and Cutaneous Fibrosis |
| title_short | Effects of Short-Wavelength Blue Light on Fibroblasts, Experimental Evidence in Wound Healing and Cutaneous Fibrosis |
| title_sort | effects of short wavelength blue light on fibroblasts experimental evidence in wound healing and cutaneous fibrosis |
| topic | photobiomodulation blue light wound healing fibroblasts skin fibrosis |
| url | https://www.mdpi.com/2673-9992/21/1/27 |
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