Brain, behavior, and physiological changes associated with predator stress–An animal model for trauma exposure in adult and neonatal rats
The use of predators and predator odor as stressors is an important and ecologically relevant model for studying the impact of behavioral responses to threat. Here we summarize neural substrates and behavioral changes in rats resulting from predator exposure. We briefly define the impact predator ex...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2024.1322273/full |
| _version_ | 1797290372412473344 |
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| author | Stacey L. Kigar Stacey L. Kigar Amelia Cuarenta Carla L. Zuniga Liza Chang Anthony P. Auger Vaishali P. Bakshi |
| author_facet | Stacey L. Kigar Stacey L. Kigar Amelia Cuarenta Carla L. Zuniga Liza Chang Anthony P. Auger Vaishali P. Bakshi |
| author_sort | Stacey L. Kigar |
| collection | DOAJ |
| description | The use of predators and predator odor as stressors is an important and ecologically relevant model for studying the impact of behavioral responses to threat. Here we summarize neural substrates and behavioral changes in rats resulting from predator exposure. We briefly define the impact predator exposure has on neural targets throughout development (neonatal, juvenile, and adulthood). These findings allow us to conceptualize the impact of predator exposure in the brain, which in turn may have broader implications for human disorders such as PTSD. Importantly, inclusion of sex as a biological variable yields distinct results that may indicate neural substrates impacted by predator exposure differ based on sex. |
| first_indexed | 2024-03-07T19:21:29Z |
| format | Article |
| id | doaj.art-eebf6544d90f4949a5ecfa6dff3d151e |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-03-07T19:21:29Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-eebf6544d90f4949a5ecfa6dff3d151e2024-02-29T11:23:37ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992024-02-011710.3389/fnmol.2024.13222731322273Brain, behavior, and physiological changes associated with predator stress–An animal model for trauma exposure in adult and neonatal ratsStacey L. Kigar0Stacey L. Kigar1Amelia Cuarenta2Carla L. Zuniga3Liza Chang4Anthony P. Auger5Vaishali P. Bakshi6Department of Psychiatry, University of Cambridge, Cambridge, United KingdomDepartment of Medicine, University of Cambridge, Cambridge, United KingdomNeuroscience Institute, Georgia State University, Atlanta, GA, United StatesDepartment of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, WI, United StatesCollege of Agricultural and Life Sciences Academic Affairs, University of Wisconsin-Madison, Madison, WI, United StatesDepartment of Psychology, University of Wisconsin-Madison, Madison, WI, United StatesDepartment of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, WI, United StatesThe use of predators and predator odor as stressors is an important and ecologically relevant model for studying the impact of behavioral responses to threat. Here we summarize neural substrates and behavioral changes in rats resulting from predator exposure. We briefly define the impact predator exposure has on neural targets throughout development (neonatal, juvenile, and adulthood). These findings allow us to conceptualize the impact of predator exposure in the brain, which in turn may have broader implications for human disorders such as PTSD. Importantly, inclusion of sex as a biological variable yields distinct results that may indicate neural substrates impacted by predator exposure differ based on sex.https://www.frontiersin.org/articles/10.3389/fnmol.2024.1322273/fullepigeneticsamygdalapost-traumatic stress disorderbiological sexferretdevelopment |
| spellingShingle | Stacey L. Kigar Stacey L. Kigar Amelia Cuarenta Carla L. Zuniga Liza Chang Anthony P. Auger Vaishali P. Bakshi Brain, behavior, and physiological changes associated with predator stress–An animal model for trauma exposure in adult and neonatal rats Frontiers in Molecular Neuroscience epigenetics amygdala post-traumatic stress disorder biological sex ferret development |
| title | Brain, behavior, and physiological changes associated with predator stress–An animal model for trauma exposure in adult and neonatal rats |
| title_full | Brain, behavior, and physiological changes associated with predator stress–An animal model for trauma exposure in adult and neonatal rats |
| title_fullStr | Brain, behavior, and physiological changes associated with predator stress–An animal model for trauma exposure in adult and neonatal rats |
| title_full_unstemmed | Brain, behavior, and physiological changes associated with predator stress–An animal model for trauma exposure in adult and neonatal rats |
| title_short | Brain, behavior, and physiological changes associated with predator stress–An animal model for trauma exposure in adult and neonatal rats |
| title_sort | brain behavior and physiological changes associated with predator stress an animal model for trauma exposure in adult and neonatal rats |
| topic | epigenetics amygdala post-traumatic stress disorder biological sex ferret development |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2024.1322273/full |
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