Enhancement of Conventional and Photodynamic Therapy for Treatment of Cervical Cancer with Cannabidiol
Cervical cancer (CC) is the fourth most diagnosed cancer in women worldwide. Conventional treatments include surgery, chemo- and radiotherapy, however these are invasive and may cause severe side effects. Furthermore, approximately 70% of late-stage CC patients experience metastasis, due to treatmen...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-04-01
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| Series: | Integrative Cancer Therapies |
| Online Access: | https://doi.org/10.1177/15347354221092706 |
| _version_ | 1828367814443925504 |
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| author | Radmila Razlog MTech Cherie Ann Kruger DTech Heidi Abrahamse PhD |
| author_facet | Radmila Razlog MTech Cherie Ann Kruger DTech Heidi Abrahamse PhD |
| author_sort | Radmila Razlog MTech |
| collection | DOAJ |
| description | Cervical cancer (CC) is the fourth most diagnosed cancer in women worldwide. Conventional treatments include surgery, chemo- and radiotherapy, however these are invasive and may cause severe side effects. Furthermore, approximately 70% of late-stage CC patients experience metastasis, due to treatment resistance and limitations. Thus, there is a dire need to investigate alternative therapeutic combination therapies. Photodynamic therapy (PDT) is an alternative CC treatment modality that has been clinically proven to treat primary CC, as well as to limit secondary metastasis. Since PDT is a non-invasive localized treatment, with fewer side effects and lessened resistance to dose repeats, it is considered far more advantageous. However, more clinical trials are required to refine its delivery and dosing, as well as improve its ability to activate specific immune responses to eradicate secondary CC spread. Cannabidiol (CBD) isolates have been shown to exert in vitro CC anticancer effects, causing apoptosis post treatment, as well as inducing specific immune responses, which obstruct tumor invasion and angiogenesis, and so hinder CC metastatic spread. This review paper discusses the current conventional and alternative PDT treatment modalities for CC, as well as their limitations over the last 10 years. It has a particular focus on the combinative administration of CBD with these treatments in order to prevent CC secondary migration and so possibly encourage future research studies to focus on this synergistic effect to eradicate CC. |
| first_indexed | 2024-04-14T06:02:10Z |
| format | Article |
| id | doaj.art-eec34e433b0c44d989349ea0dad936b1 |
| institution | Directory Open Access Journal |
| issn | 1534-7354 1552-695X |
| language | English |
| last_indexed | 2024-04-14T06:02:10Z |
| publishDate | 2022-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Integrative Cancer Therapies |
| spelling | doaj.art-eec34e433b0c44d989349ea0dad936b12022-12-22T02:08:42ZengSAGE PublishingIntegrative Cancer Therapies1534-73541552-695X2022-04-012110.1177/15347354221092706Enhancement of Conventional and Photodynamic Therapy for Treatment of Cervical Cancer with CannabidiolRadmila Razlog MTech0Cherie Ann Kruger DTech1Heidi Abrahamse PhD2Department of Complementary Medicine, Faculty of Health Sciences, University of Johannesburg, Doornfontein, Johannesburg, South AfricaLaser Research Centre, Faculty of Health Sciences, University of Johannesburg, Doornfontein, Johannesburg, South AfricaLaser Research Centre, Faculty of Health Sciences, University of Johannesburg, Doornfontein, Johannesburg, South AfricaCervical cancer (CC) is the fourth most diagnosed cancer in women worldwide. Conventional treatments include surgery, chemo- and radiotherapy, however these are invasive and may cause severe side effects. Furthermore, approximately 70% of late-stage CC patients experience metastasis, due to treatment resistance and limitations. Thus, there is a dire need to investigate alternative therapeutic combination therapies. Photodynamic therapy (PDT) is an alternative CC treatment modality that has been clinically proven to treat primary CC, as well as to limit secondary metastasis. Since PDT is a non-invasive localized treatment, with fewer side effects and lessened resistance to dose repeats, it is considered far more advantageous. However, more clinical trials are required to refine its delivery and dosing, as well as improve its ability to activate specific immune responses to eradicate secondary CC spread. Cannabidiol (CBD) isolates have been shown to exert in vitro CC anticancer effects, causing apoptosis post treatment, as well as inducing specific immune responses, which obstruct tumor invasion and angiogenesis, and so hinder CC metastatic spread. This review paper discusses the current conventional and alternative PDT treatment modalities for CC, as well as their limitations over the last 10 years. It has a particular focus on the combinative administration of CBD with these treatments in order to prevent CC secondary migration and so possibly encourage future research studies to focus on this synergistic effect to eradicate CC.https://doi.org/10.1177/15347354221092706 |
| spellingShingle | Radmila Razlog MTech Cherie Ann Kruger DTech Heidi Abrahamse PhD Enhancement of Conventional and Photodynamic Therapy for Treatment of Cervical Cancer with Cannabidiol Integrative Cancer Therapies |
| title | Enhancement of Conventional and Photodynamic Therapy for Treatment of Cervical Cancer with Cannabidiol |
| title_full | Enhancement of Conventional and Photodynamic Therapy for Treatment of Cervical Cancer with Cannabidiol |
| title_fullStr | Enhancement of Conventional and Photodynamic Therapy for Treatment of Cervical Cancer with Cannabidiol |
| title_full_unstemmed | Enhancement of Conventional and Photodynamic Therapy for Treatment of Cervical Cancer with Cannabidiol |
| title_short | Enhancement of Conventional and Photodynamic Therapy for Treatment of Cervical Cancer with Cannabidiol |
| title_sort | enhancement of conventional and photodynamic therapy for treatment of cervical cancer with cannabidiol |
| url | https://doi.org/10.1177/15347354221092706 |
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