Are the Derived Indexes of Peripheral Whole Blood Cell Counts (NLR, PLR, LMR/MLR) Clinically Significant Prognostic Biomarkers in Multiple Myeloma? A Systematic Review And Meta-Analysis
BackgroundMultiple myeloma (MM) is an incurable malignant plasma cell tumor. Whole blood cell count (WBCC) derived indexes are widely used as a predictive biomarker for various types of solid and hematological malignant tumors. Our study is to evaluate its effectiveness in MM by meta-analysis.Method...
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.766672/full |
| _version_ | 1819012977262592000 |
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| author | Xinwen Zhang Xinwen Zhang Jialin Duan Jialin Duan Zhenyu Wen Hao Xiong Hao Xiong Xiaomin Chen Xiaomin Chen Yang Liu Yang Liu Kunyu Liao Kunyu Liao Chunlan Huang Chunlan Huang |
| author_facet | Xinwen Zhang Xinwen Zhang Jialin Duan Jialin Duan Zhenyu Wen Hao Xiong Hao Xiong Xiaomin Chen Xiaomin Chen Yang Liu Yang Liu Kunyu Liao Kunyu Liao Chunlan Huang Chunlan Huang |
| author_sort | Xinwen Zhang |
| collection | DOAJ |
| description | BackgroundMultiple myeloma (MM) is an incurable malignant plasma cell tumor. Whole blood cell count (WBCC) derived indexes are widely used as a predictive biomarker for various types of solid and hematological malignant tumors. Our study is to evaluate its effectiveness in MM by meta-analysis.MethodsRelevant literatures were retrieved from PubMed, Embase and Web of Science databases according to PRISMA guideline. All relevant parameters were extracted and combined for statistical analysis.ResultsNineteen studies incorporating 3818 MM patients were eventually included in this meta-analysis. 13 studies evaluated that elevated NLR was significantly associated with poor survival outcomes (OS: HR=2.04, P<0.001; PFS: HR=1.96, P=0.003). Elevated NLR was revealed to correlate with ISS stage (ISS III VS I-II, OR=2.23, P=0.003). A total of 7 studies have shown that elevated LMR predicts a better prognosis in MM patients (OS: HR=0.57, P<0.001; PFS: HR=0.49, P<0.05), and two other studies demonstrated that increased MLR was related to poor OS/PFS (OS: HR=1.58, P<0.05; PFS: HR=1.60, P<0.05). However, in the other 6 studies including 1560 patients, the prognostic value of PLR had not been confirmed (OS: HR=0.89, P>0.05; PFS: HR=0.87, P>0.05).ConclusionsThe indexes NLR and LMR/MLR derived from WBCC were validated to be useful biomarkers to predict the prognosis in MM patients, but the evidence of PLR was insufficient. |
| first_indexed | 2024-12-21T01:52:37Z |
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| id | doaj.art-eec690c52bbb4f60b59c45289f1ae5ee |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-21T01:52:37Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-eec690c52bbb4f60b59c45289f1ae5ee2022-12-21T19:19:51ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-11-011110.3389/fonc.2021.766672766672Are the Derived Indexes of Peripheral Whole Blood Cell Counts (NLR, PLR, LMR/MLR) Clinically Significant Prognostic Biomarkers in Multiple Myeloma? A Systematic Review And Meta-AnalysisXinwen Zhang0Xinwen Zhang1Jialin Duan2Jialin Duan3Zhenyu Wen4Hao Xiong5Hao Xiong6Xiaomin Chen7Xiaomin Chen8Yang Liu9Yang Liu10Kunyu Liao11Kunyu Liao12Chunlan Huang13Chunlan Huang14Stem Cell Laboratory, Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Hematology, Affiliated Hospital of Southwest Medical University, Luzhou, ChinaStem Cell Laboratory, Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Hematology, Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Orthopedics, Affiliated Hospital of Southwest Medical University, Luzhou, ChinaStem Cell Laboratory, Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Hematology, Affiliated Hospital of Southwest Medical University, Luzhou, ChinaStem Cell Laboratory, Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Hematology, Affiliated Hospital of Southwest Medical University, Luzhou, ChinaStem Cell Laboratory, Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Hematology, Affiliated Hospital of Southwest Medical University, Luzhou, ChinaStem Cell Laboratory, Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Hematology, Affiliated Hospital of Southwest Medical University, Luzhou, ChinaStem Cell Laboratory, Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Hematology, Affiliated Hospital of Southwest Medical University, Luzhou, ChinaBackgroundMultiple myeloma (MM) is an incurable malignant plasma cell tumor. Whole blood cell count (WBCC) derived indexes are widely used as a predictive biomarker for various types of solid and hematological malignant tumors. Our study is to evaluate its effectiveness in MM by meta-analysis.MethodsRelevant literatures were retrieved from PubMed, Embase and Web of Science databases according to PRISMA guideline. All relevant parameters were extracted and combined for statistical analysis.ResultsNineteen studies incorporating 3818 MM patients were eventually included in this meta-analysis. 13 studies evaluated that elevated NLR was significantly associated with poor survival outcomes (OS: HR=2.04, P<0.001; PFS: HR=1.96, P=0.003). Elevated NLR was revealed to correlate with ISS stage (ISS III VS I-II, OR=2.23, P=0.003). A total of 7 studies have shown that elevated LMR predicts a better prognosis in MM patients (OS: HR=0.57, P<0.001; PFS: HR=0.49, P<0.05), and two other studies demonstrated that increased MLR was related to poor OS/PFS (OS: HR=1.58, P<0.05; PFS: HR=1.60, P<0.05). However, in the other 6 studies including 1560 patients, the prognostic value of PLR had not been confirmed (OS: HR=0.89, P>0.05; PFS: HR=0.87, P>0.05).ConclusionsThe indexes NLR and LMR/MLR derived from WBCC were validated to be useful biomarkers to predict the prognosis in MM patients, but the evidence of PLR was insufficient.https://www.frontiersin.org/articles/10.3389/fonc.2021.766672/fullmultiple myeloma (MM)neutrophil-to-lymphocyte ratio (NLR)platelet-to-lymphocyte ratio (PLR)lymphocyte-to-monocyte ratio (LMR)monocyte-to-lymphocyte ratio (MLR)prognosis |
| spellingShingle | Xinwen Zhang Xinwen Zhang Jialin Duan Jialin Duan Zhenyu Wen Hao Xiong Hao Xiong Xiaomin Chen Xiaomin Chen Yang Liu Yang Liu Kunyu Liao Kunyu Liao Chunlan Huang Chunlan Huang Are the Derived Indexes of Peripheral Whole Blood Cell Counts (NLR, PLR, LMR/MLR) Clinically Significant Prognostic Biomarkers in Multiple Myeloma? A Systematic Review And Meta-Analysis Frontiers in Oncology multiple myeloma (MM) neutrophil-to-lymphocyte ratio (NLR) platelet-to-lymphocyte ratio (PLR) lymphocyte-to-monocyte ratio (LMR) monocyte-to-lymphocyte ratio (MLR) prognosis |
| title | Are the Derived Indexes of Peripheral Whole Blood Cell Counts (NLR, PLR, LMR/MLR) Clinically Significant Prognostic Biomarkers in Multiple Myeloma? A Systematic Review And Meta-Analysis |
| title_full | Are the Derived Indexes of Peripheral Whole Blood Cell Counts (NLR, PLR, LMR/MLR) Clinically Significant Prognostic Biomarkers in Multiple Myeloma? A Systematic Review And Meta-Analysis |
| title_fullStr | Are the Derived Indexes of Peripheral Whole Blood Cell Counts (NLR, PLR, LMR/MLR) Clinically Significant Prognostic Biomarkers in Multiple Myeloma? A Systematic Review And Meta-Analysis |
| title_full_unstemmed | Are the Derived Indexes of Peripheral Whole Blood Cell Counts (NLR, PLR, LMR/MLR) Clinically Significant Prognostic Biomarkers in Multiple Myeloma? A Systematic Review And Meta-Analysis |
| title_short | Are the Derived Indexes of Peripheral Whole Blood Cell Counts (NLR, PLR, LMR/MLR) Clinically Significant Prognostic Biomarkers in Multiple Myeloma? A Systematic Review And Meta-Analysis |
| title_sort | are the derived indexes of peripheral whole blood cell counts nlr plr lmr mlr clinically significant prognostic biomarkers in multiple myeloma a systematic review and meta analysis |
| topic | multiple myeloma (MM) neutrophil-to-lymphocyte ratio (NLR) platelet-to-lymphocyte ratio (PLR) lymphocyte-to-monocyte ratio (LMR) monocyte-to-lymphocyte ratio (MLR) prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.766672/full |
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