Plasma-Conditioned Liquids as Anticancer Therapies In Vivo: Current State and Future Directions
Plasma-conditioned liquids (PCL) are gaining increasing attention in the medical field, especially in oncology, and translation to the clinics is advancing on a good path. This emerging technology involving cold plasmas has great potential as a therapeutic approach in cancer diseases, as PCL have be...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/3/452 |
| _version_ | 1797407536897327104 |
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| author | Xavi Solé-Martí Albert Espona-Noguera Maria-Pau Ginebra Cristina Canal |
| author_facet | Xavi Solé-Martí Albert Espona-Noguera Maria-Pau Ginebra Cristina Canal |
| author_sort | Xavi Solé-Martí |
| collection | DOAJ |
| description | Plasma-conditioned liquids (PCL) are gaining increasing attention in the medical field, especially in oncology, and translation to the clinics is advancing on a good path. This emerging technology involving cold plasmas has great potential as a therapeutic approach in cancer diseases, as PCL have been shown to selectively kill cancer cells by triggering apoptotic mechanisms without damaging healthy cells. In this context, PCL can be injected near the tumor or intratumorally, thereby allowing the treatment of malignant tumors located in internal organs that are not accessible for direct cold atmospheric plasma (CAP) treatment. Therefore, PCL constitutes a very interesting and minimally invasive alternative to direct CAP treatment in cancer therapy, avoiding surgeries and allowing multiple local administrations. As the field advances, it is progressively moving to the evaluation of the therapeutic effects of PCL in in vivo scenarios. Exciting developments are pushing forward the clinical translation of this novel therapy. However, there is still room for research, as the quantification and identification of reactive oxygen and nitrogen species (RONS) in in vivo conditions is not yet clarified, dosage regimens are highly variable among studies, and other more relevant in vivo models could be used. In this context, this work aims to present a critical review of the state of the field of PCL as anticancer agents applied in in vivo studies. |
| first_indexed | 2024-03-09T03:42:57Z |
| format | Article |
| id | doaj.art-eec8165aaff247e6a75109c59cbc38b3 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T03:42:57Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-eec8165aaff247e6a75109c59cbc38b32023-12-03T14:38:13ZengMDPI AGCancers2072-66942021-01-0113345210.3390/cancers13030452Plasma-Conditioned Liquids as Anticancer Therapies In Vivo: Current State and Future DirectionsXavi Solé-Martí0Albert Espona-Noguera1Maria-Pau Ginebra2Cristina Canal3Biomaterials, Biomechanics and Tissue Engineering Group, Department Materials Science and Engineering, Escola d’Enginyeria Barcelona Est (EEBE), Universitat Politècnica de Catalunya (UPC), 08930 Barcelona, SpainBiomaterials, Biomechanics and Tissue Engineering Group, Department Materials Science and Engineering, Escola d’Enginyeria Barcelona Est (EEBE), Universitat Politècnica de Catalunya (UPC), 08930 Barcelona, SpainBiomaterials, Biomechanics and Tissue Engineering Group, Department Materials Science and Engineering, Escola d’Enginyeria Barcelona Est (EEBE), Universitat Politècnica de Catalunya (UPC), 08930 Barcelona, SpainBiomaterials, Biomechanics and Tissue Engineering Group, Department Materials Science and Engineering, Escola d’Enginyeria Barcelona Est (EEBE), Universitat Politècnica de Catalunya (UPC), 08930 Barcelona, SpainPlasma-conditioned liquids (PCL) are gaining increasing attention in the medical field, especially in oncology, and translation to the clinics is advancing on a good path. This emerging technology involving cold plasmas has great potential as a therapeutic approach in cancer diseases, as PCL have been shown to selectively kill cancer cells by triggering apoptotic mechanisms without damaging healthy cells. In this context, PCL can be injected near the tumor or intratumorally, thereby allowing the treatment of malignant tumors located in internal organs that are not accessible for direct cold atmospheric plasma (CAP) treatment. Therefore, PCL constitutes a very interesting and minimally invasive alternative to direct CAP treatment in cancer therapy, avoiding surgeries and allowing multiple local administrations. As the field advances, it is progressively moving to the evaluation of the therapeutic effects of PCL in in vivo scenarios. Exciting developments are pushing forward the clinical translation of this novel therapy. However, there is still room for research, as the quantification and identification of reactive oxygen and nitrogen species (RONS) in in vivo conditions is not yet clarified, dosage regimens are highly variable among studies, and other more relevant in vivo models could be used. In this context, this work aims to present a critical review of the state of the field of PCL as anticancer agents applied in in vivo studies.https://www.mdpi.com/2072-6694/13/3/452plasma-conditioned liquidscancerin vivocold atmospheric plasma |
| spellingShingle | Xavi Solé-Martí Albert Espona-Noguera Maria-Pau Ginebra Cristina Canal Plasma-Conditioned Liquids as Anticancer Therapies In Vivo: Current State and Future Directions Cancers plasma-conditioned liquids cancer in vivo cold atmospheric plasma |
| title | Plasma-Conditioned Liquids as Anticancer Therapies In Vivo: Current State and Future Directions |
| title_full | Plasma-Conditioned Liquids as Anticancer Therapies In Vivo: Current State and Future Directions |
| title_fullStr | Plasma-Conditioned Liquids as Anticancer Therapies In Vivo: Current State and Future Directions |
| title_full_unstemmed | Plasma-Conditioned Liquids as Anticancer Therapies In Vivo: Current State and Future Directions |
| title_short | Plasma-Conditioned Liquids as Anticancer Therapies In Vivo: Current State and Future Directions |
| title_sort | plasma conditioned liquids as anticancer therapies in vivo current state and future directions |
| topic | plasma-conditioned liquids cancer in vivo cold atmospheric plasma |
| url | https://www.mdpi.com/2072-6694/13/3/452 |
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