Prognosis of Patients With Testicular Carcinoma Is Dependent on Metastatic Site
Background: Existing data on the association of metastatic sites and prognosis of patients with metastatic testicular malignancy are limited. In this study, the association of survival outcome and the prognostic value of different metastatic sites in patients with metastatic testicular cancer was in...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2019.01495/full |
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| author | Peihang Xu Peihang Xu Jun Wang Jun Wang Mierxiati Abudurexiti Mierxiati Abudurexiti Shengming Jin Shengming Jin Junlong Wu Junlong Wu Yijun Shen Yijun Shen Dingwei Ye Dingwei Ye |
| author_facet | Peihang Xu Peihang Xu Jun Wang Jun Wang Mierxiati Abudurexiti Mierxiati Abudurexiti Shengming Jin Shengming Jin Junlong Wu Junlong Wu Yijun Shen Yijun Shen Dingwei Ye Dingwei Ye |
| author_sort | Peihang Xu |
| collection | DOAJ |
| description | Background: Existing data on the association of metastatic sites and prognosis of patients with metastatic testicular malignancy are limited. In this study, the association of survival outcome and the prognostic value of different metastatic sites in patients with metastatic testicular cancer was investigated.Methods: A dataset from the Surveillance, Epidemiology and End Results (SEER) survey was selected for a retrospective metastatic testicular cancer cohort study. Patients with different metastatic sites were divided into corresponding groups for further analysis. Kaplan-Meier analysis with log-rank test was implemented for comparison of the survival distribution of cases. Multivariate Cox regression models were then applied to analyze the association of distant metastases with survival for all selected patients and subgroup based on different histological type with a single metastatic site.Results: A total of 1,661 patients treated for metastatic testicular malignant tumors between 2010 to 2016 were enrolled in this cohort study. Upon initial diagnosis, 61.9, 15.2, 6.7, 6.4, and 36.2% of patients were found to have lung, liver, bone, brain, and distant lymph nodes metastatic sites, respectively. Patients with lung, liver, or bone metastases showed more undesirable prognosis for overall survival (OS) and cancer-specific survival (CSS), in contrast with those with distant lymph node metastases (all P < 0.05). In comparison with patients with more than one metastatic site, those with a single metastasis had extended OS and CSS (both P < 0.001). In patients with a single metastatic site, Kaplan-Meier analysis and multivariate Cox regression demonstrated the association of bone and liver with the worst two groups of OS and CSS. Multivariate Cox models based on histological type showed different prognostic values of metastases in patients with seminoma or non-seminomatous germ cell tumors.Conclusion: There is much heterogeneity in the oncological outcome of site-specific metastatic patients. Metastatic profiles and the prognostic value of metastases are dependent on the histological type in TC patients. Distant lymph nodes and lung metastases indicate favorable prognostic factors, while bone and liver metastases indicate negative survival outcomes in TC. |
| first_indexed | 2024-12-19T14:52:06Z |
| format | Article |
| id | doaj.art-eec882eed4f4427aaa050b4c8ef90b6e |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-19T14:52:06Z |
| publishDate | 2020-01-01 |
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| series | Frontiers in Oncology |
| spelling | doaj.art-eec882eed4f4427aaa050b4c8ef90b6e2022-12-21T20:16:49ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-01-01910.3389/fonc.2019.01495471527Prognosis of Patients With Testicular Carcinoma Is Dependent on Metastatic SitePeihang Xu0Peihang Xu1Jun Wang2Jun Wang3Mierxiati Abudurexiti4Mierxiati Abudurexiti5Shengming Jin6Shengming Jin7Junlong Wu8Junlong Wu9Yijun Shen10Yijun Shen11Dingwei Ye12Dingwei Ye13Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Urology, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Urology, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Urology, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Urology, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Urology, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Urology, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, ChinaBackground: Existing data on the association of metastatic sites and prognosis of patients with metastatic testicular malignancy are limited. In this study, the association of survival outcome and the prognostic value of different metastatic sites in patients with metastatic testicular cancer was investigated.Methods: A dataset from the Surveillance, Epidemiology and End Results (SEER) survey was selected for a retrospective metastatic testicular cancer cohort study. Patients with different metastatic sites were divided into corresponding groups for further analysis. Kaplan-Meier analysis with log-rank test was implemented for comparison of the survival distribution of cases. Multivariate Cox regression models were then applied to analyze the association of distant metastases with survival for all selected patients and subgroup based on different histological type with a single metastatic site.Results: A total of 1,661 patients treated for metastatic testicular malignant tumors between 2010 to 2016 were enrolled in this cohort study. Upon initial diagnosis, 61.9, 15.2, 6.7, 6.4, and 36.2% of patients were found to have lung, liver, bone, brain, and distant lymph nodes metastatic sites, respectively. Patients with lung, liver, or bone metastases showed more undesirable prognosis for overall survival (OS) and cancer-specific survival (CSS), in contrast with those with distant lymph node metastases (all P < 0.05). In comparison with patients with more than one metastatic site, those with a single metastasis had extended OS and CSS (both P < 0.001). In patients with a single metastatic site, Kaplan-Meier analysis and multivariate Cox regression demonstrated the association of bone and liver with the worst two groups of OS and CSS. Multivariate Cox models based on histological type showed different prognostic values of metastases in patients with seminoma or non-seminomatous germ cell tumors.Conclusion: There is much heterogeneity in the oncological outcome of site-specific metastatic patients. Metastatic profiles and the prognostic value of metastases are dependent on the histological type in TC patients. Distant lymph nodes and lung metastases indicate favorable prognostic factors, while bone and liver metastases indicate negative survival outcomes in TC.https://www.frontiersin.org/article/10.3389/fonc.2019.01495/fullmetastatic testicular cancerprognosismetastatic sitenumber of metastasesSEER |
| spellingShingle | Peihang Xu Peihang Xu Jun Wang Jun Wang Mierxiati Abudurexiti Mierxiati Abudurexiti Shengming Jin Shengming Jin Junlong Wu Junlong Wu Yijun Shen Yijun Shen Dingwei Ye Dingwei Ye Prognosis of Patients With Testicular Carcinoma Is Dependent on Metastatic Site Frontiers in Oncology metastatic testicular cancer prognosis metastatic site number of metastases SEER |
| title | Prognosis of Patients With Testicular Carcinoma Is Dependent on Metastatic Site |
| title_full | Prognosis of Patients With Testicular Carcinoma Is Dependent on Metastatic Site |
| title_fullStr | Prognosis of Patients With Testicular Carcinoma Is Dependent on Metastatic Site |
| title_full_unstemmed | Prognosis of Patients With Testicular Carcinoma Is Dependent on Metastatic Site |
| title_short | Prognosis of Patients With Testicular Carcinoma Is Dependent on Metastatic Site |
| title_sort | prognosis of patients with testicular carcinoma is dependent on metastatic site |
| topic | metastatic testicular cancer prognosis metastatic site number of metastases SEER |
| url | https://www.frontiersin.org/article/10.3389/fonc.2019.01495/full |
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