Dual and Recombinant Infections: An Integral Part of the HIV-1 Epidemic in Brazil
We systematically evaluated multiple and recombinant infections in an HIV-infected population selected for vaccine trials. Seventy-nine HIV-1 infected persons in a clinical cohort study in Rio de Janeiro, Brazil, were evaluated for 1 year. A combination of molecular screening assays and DNA sequenci...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
1999-02-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/5/1/99-0108_article |
| _version_ | 1819231483842265088 |
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| author | Artur Ramos Amilcar Tanuri Mauro Schechter Mark A. Rayfield Dale J. Hu Maulori C. Cabral Claudiu I. Bandea James Baggs Danuta Pieniazek |
| author_facet | Artur Ramos Amilcar Tanuri Mauro Schechter Mark A. Rayfield Dale J. Hu Maulori C. Cabral Claudiu I. Bandea James Baggs Danuta Pieniazek |
| author_sort | Artur Ramos |
| collection | DOAJ |
| description | We systematically evaluated multiple and recombinant infections in an HIV-infected population selected for vaccine trials. Seventy-nine HIV-1 infected persons in a clinical cohort study in Rio de Janeiro, Brazil, were evaluated for 1 year. A combination of molecular screening assays and DNA sequencing showed 3 dual infections (3.8%), 6 recombinant infections (7.6%), and 70 (88.6%) infections involving single viral subtypes. In the three dual infections, we identified HIV-1 subtypes F and B, F and D, and B and D; in contrast, the single and recombinant infections involved only HIV-1 subtypes B and F. The recombinants had five distinct B/F mosaic patterns: Bgag-p17/Bgag -p24/Fpol/Benv , Fgag-p17/Bgag -p24/Fpol/Fenv , Bgag-p17/B-Fgag -p24/Fpol/Fenv , Bgag-p17/B-Fgag -p24/Fpol/Benv , and Fgag-p17/B-Fgag -p24/Fpol/Fenv . No association was found between dual or recombinant infections and demographic or clinical variables. These findings indicate that dual and recombinant infections are emerging as an integral part of the HIV/AIDS epidemic in Brazil and emphasize the heterogenous character of epidemics emerging in countries where multiple viral subtypes coexist. |
| first_indexed | 2024-12-23T11:45:41Z |
| format | Article |
| id | doaj.art-eec995d19fa04a70869917175f99732a |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-23T11:45:41Z |
| publishDate | 1999-02-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-eec995d19fa04a70869917175f99732a2022-12-21T17:48:22ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60591999-02-0151657410.3201/eid0501.990108Dual and Recombinant Infections: An Integral Part of the HIV-1 Epidemic in BrazilArtur RamosAmilcar TanuriMauro SchechterMark A. RayfieldDale J. HuMaulori C. CabralClaudiu I. BandeaJames BaggsDanuta PieniazekWe systematically evaluated multiple and recombinant infections in an HIV-infected population selected for vaccine trials. Seventy-nine HIV-1 infected persons in a clinical cohort study in Rio de Janeiro, Brazil, were evaluated for 1 year. A combination of molecular screening assays and DNA sequencing showed 3 dual infections (3.8%), 6 recombinant infections (7.6%), and 70 (88.6%) infections involving single viral subtypes. In the three dual infections, we identified HIV-1 subtypes F and B, F and D, and B and D; in contrast, the single and recombinant infections involved only HIV-1 subtypes B and F. The recombinants had five distinct B/F mosaic patterns: Bgag-p17/Bgag -p24/Fpol/Benv , Fgag-p17/Bgag -p24/Fpol/Fenv , Bgag-p17/B-Fgag -p24/Fpol/Fenv , Bgag-p17/B-Fgag -p24/Fpol/Benv , and Fgag-p17/B-Fgag -p24/Fpol/Fenv . No association was found between dual or recombinant infections and demographic or clinical variables. These findings indicate that dual and recombinant infections are emerging as an integral part of the HIV/AIDS epidemic in Brazil and emphasize the heterogenous character of epidemics emerging in countries where multiple viral subtypes coexist.https://wwwnc.cdc.gov/eid/article/5/1/99-0108_articleBrazilUnited States |
| spellingShingle | Artur Ramos Amilcar Tanuri Mauro Schechter Mark A. Rayfield Dale J. Hu Maulori C. Cabral Claudiu I. Bandea James Baggs Danuta Pieniazek Dual and Recombinant Infections: An Integral Part of the HIV-1 Epidemic in Brazil Emerging Infectious Diseases Brazil United States |
| title | Dual and Recombinant Infections: An Integral Part of the HIV-1 Epidemic in Brazil |
| title_full | Dual and Recombinant Infections: An Integral Part of the HIV-1 Epidemic in Brazil |
| title_fullStr | Dual and Recombinant Infections: An Integral Part of the HIV-1 Epidemic in Brazil |
| title_full_unstemmed | Dual and Recombinant Infections: An Integral Part of the HIV-1 Epidemic in Brazil |
| title_short | Dual and Recombinant Infections: An Integral Part of the HIV-1 Epidemic in Brazil |
| title_sort | dual and recombinant infections an integral part of the hiv 1 epidemic in brazil |
| topic | Brazil United States |
| url | https://wwwnc.cdc.gov/eid/article/5/1/99-0108_article |
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