Pneumococcal Vaccination in Adults: A Narrative Review of Considerations for Individualized Decision-Making
Pneumococcal disease remains one of the major causes of severe disease in both children and adults. Severe disease may be prevented by pneumococcal polysaccharide and conjugate vaccines, which currently cover more than 20 serotypes. However, unlike routine pneumococcal vaccination in children, guide...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/11/5/908 |
| _version_ | 1797598194378473472 |
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| author | Kay Choong See |
| author_facet | Kay Choong See |
| author_sort | Kay Choong See |
| collection | DOAJ |
| description | Pneumococcal disease remains one of the major causes of severe disease in both children and adults. Severe disease may be prevented by pneumococcal polysaccharide and conjugate vaccines, which currently cover more than 20 serotypes. However, unlike routine pneumococcal vaccination in children, guidelines promote only limited pneumococcal vaccination in adults, and do not cater for decision-making for individual patients. In this narrative review, considerations for individualized decision-making are identified and discussed. This review identifies and discusses considerations for individualized decision-making, including the risk of severe disease, immunogenicity, clinical efficacy, mucosal immunity, herd immunity, concomitant administration with other vaccines, waning immunity, and replacement strains. |
| first_indexed | 2024-03-11T03:15:55Z |
| format | Article |
| id | doaj.art-eec9e0506ee64372849354cb4b814776 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-11T03:15:55Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-eec9e0506ee64372849354cb4b8147762023-11-18T03:35:34ZengMDPI AGVaccines2076-393X2023-04-0111590810.3390/vaccines11050908Pneumococcal Vaccination in Adults: A Narrative Review of Considerations for Individualized Decision-MakingKay Choong See0Department of Medicine, National University Hospital, Singapore 119228, SingaporePneumococcal disease remains one of the major causes of severe disease in both children and adults. Severe disease may be prevented by pneumococcal polysaccharide and conjugate vaccines, which currently cover more than 20 serotypes. However, unlike routine pneumococcal vaccination in children, guidelines promote only limited pneumococcal vaccination in adults, and do not cater for decision-making for individual patients. In this narrative review, considerations for individualized decision-making are identified and discussed. This review identifies and discusses considerations for individualized decision-making, including the risk of severe disease, immunogenicity, clinical efficacy, mucosal immunity, herd immunity, concomitant administration with other vaccines, waning immunity, and replacement strains.https://www.mdpi.com/2076-393X/11/5/908immunityherdimmunitymucosalimmunogenicityvaccine |
| spellingShingle | Kay Choong See Pneumococcal Vaccination in Adults: A Narrative Review of Considerations for Individualized Decision-Making Vaccines immunity herd immunity mucosal immunogenicity vaccine |
| title | Pneumococcal Vaccination in Adults: A Narrative Review of Considerations for Individualized Decision-Making |
| title_full | Pneumococcal Vaccination in Adults: A Narrative Review of Considerations for Individualized Decision-Making |
| title_fullStr | Pneumococcal Vaccination in Adults: A Narrative Review of Considerations for Individualized Decision-Making |
| title_full_unstemmed | Pneumococcal Vaccination in Adults: A Narrative Review of Considerations for Individualized Decision-Making |
| title_short | Pneumococcal Vaccination in Adults: A Narrative Review of Considerations for Individualized Decision-Making |
| title_sort | pneumococcal vaccination in adults a narrative review of considerations for individualized decision making |
| topic | immunity herd immunity mucosal immunogenicity vaccine |
| url | https://www.mdpi.com/2076-393X/11/5/908 |
| work_keys_str_mv | AT kaychoongsee pneumococcalvaccinationinadultsanarrativereviewofconsiderationsforindividualizeddecisionmaking |