Implications of regulatory T cells in non-lymphoid tissue physiology and pathophysiology
Treg cells have been initially described as gatekeepers for the control of autoimmunity, as they can actively suppress the activity of other immune cells. However, their role goes beyond this as Treg cells further control immune responses during infections and tumor development. Furthermore, Treg ce...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.954798/full |
| _version_ | 1818189279822610432 |
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| author | Darya Malko Darya Malko Tarek Elmzzahi Tarek Elmzzahi Marc Beyer Marc Beyer |
| author_facet | Darya Malko Darya Malko Tarek Elmzzahi Tarek Elmzzahi Marc Beyer Marc Beyer |
| author_sort | Darya Malko |
| collection | DOAJ |
| description | Treg cells have been initially described as gatekeepers for the control of autoimmunity, as they can actively suppress the activity of other immune cells. However, their role goes beyond this as Treg cells further control immune responses during infections and tumor development. Furthermore, Treg cells can acquire additional properties for e.g., the control of tissue homeostasis. This is instructed by a specific differentiation program and the acquisition of effector properties unique to Treg cells in non-lymphoid tissues. These tissue Treg cells can further adapt to their tissue environment and acquire distinct functional properties through specific transcription factors activated by a combination of tissue derived factors, including tissue-specific antigens and cytokines. In this review, we will focus on recent findings extending our current understanding of the role and differentiation of these tissue Treg cells. As such we will highlight the importance of tissue Treg cells for tissue maintenance, regeneration, and repair in adipose tissue, muscle, CNS, liver, kidney, reproductive organs, and the lung. |
| first_indexed | 2024-12-11T23:40:18Z |
| format | Article |
| id | doaj.art-eeca4a278f41417db7bd5c7c4b22c50e |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T23:40:18Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-eeca4a278f41417db7bd5c7c4b22c50e2022-12-22T00:45:46ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-07-011310.3389/fimmu.2022.954798954798Implications of regulatory T cells in non-lymphoid tissue physiology and pathophysiologyDarya Malko0Darya Malko1Tarek Elmzzahi2Tarek Elmzzahi3Marc Beyer4Marc Beyer5Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, AustraliaImmunogenomics and Neurodegeneration, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, GermanyDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, AustraliaImmunogenomics and Neurodegeneration, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, GermanyImmunogenomics and Neurodegeneration, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, GermanyPlatform foR SinglE Cell GenomIcS and Epigenomics (PRECISE), Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) and University of Bonn, Bonn, GermanyTreg cells have been initially described as gatekeepers for the control of autoimmunity, as they can actively suppress the activity of other immune cells. However, their role goes beyond this as Treg cells further control immune responses during infections and tumor development. Furthermore, Treg cells can acquire additional properties for e.g., the control of tissue homeostasis. This is instructed by a specific differentiation program and the acquisition of effector properties unique to Treg cells in non-lymphoid tissues. These tissue Treg cells can further adapt to their tissue environment and acquire distinct functional properties through specific transcription factors activated by a combination of tissue derived factors, including tissue-specific antigens and cytokines. In this review, we will focus on recent findings extending our current understanding of the role and differentiation of these tissue Treg cells. As such we will highlight the importance of tissue Treg cells for tissue maintenance, regeneration, and repair in adipose tissue, muscle, CNS, liver, kidney, reproductive organs, and the lung.https://www.frontiersin.org/articles/10.3389/fimmu.2022.954798/fullregulatory T cellsTreg cellstissue homeostasisFoxP3tissue Treg cellsnonlymphoid tissues |
| spellingShingle | Darya Malko Darya Malko Tarek Elmzzahi Tarek Elmzzahi Marc Beyer Marc Beyer Implications of regulatory T cells in non-lymphoid tissue physiology and pathophysiology Frontiers in Immunology regulatory T cells Treg cells tissue homeostasis FoxP3 tissue Treg cells nonlymphoid tissues |
| title | Implications of regulatory T cells in non-lymphoid tissue physiology and pathophysiology |
| title_full | Implications of regulatory T cells in non-lymphoid tissue physiology and pathophysiology |
| title_fullStr | Implications of regulatory T cells in non-lymphoid tissue physiology and pathophysiology |
| title_full_unstemmed | Implications of regulatory T cells in non-lymphoid tissue physiology and pathophysiology |
| title_short | Implications of regulatory T cells in non-lymphoid tissue physiology and pathophysiology |
| title_sort | implications of regulatory t cells in non lymphoid tissue physiology and pathophysiology |
| topic | regulatory T cells Treg cells tissue homeostasis FoxP3 tissue Treg cells nonlymphoid tissues |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.954798/full |
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